A5012902448- Molecular Sensors and Ion Detection
- Luminescence and Fluorescent Materials
- Metal complexes synthesis and properties
- Lanthanide and Transition Metal Complexes
- Innovative Teaching and Learning Methods
- Magnetism in coordination complexes
- Analytical Chemistry and Sensors
- Innovative Teaching Methods
- Advanced biosensing and bioanalysis techniques
- Radioactive element chemistry and processing
- Online and Blended Learning
- Nanoparticles: synthesis and applications
- Experimental Learning in Engineering
- Transgenic Plants and Applications
- Plant-based Medicinal Research
- E-Learning and Knowledge Management
- Inorganic and Organometallic Chemistry
- RNA Interference and Gene Delivery
- Electrochemical Analysis and Applications
- Chromatography in Natural Products
- Synthesis and Biological Evaluation
- Ginseng Biological Effects and Applications
- Maternal and Neonatal Healthcare
- Chemical Safety and Risk Management
- Electrochemical sensors and biosensors
Canterbury Christ Church University
2013-2024
Universidade de Santiago de Compostela
1998-2009
Imperial College London
2004
Two novel fluorescent probes bearing a single (P) and two (a podand-like structure, L) pyrene units derived from 1,5-bis(2-aminophenoxy)-3-oxopentane have been synthesized investigated in dioxane using UV–vis absorption, steady-state time-resolved (in picosecond time scale) emission spectroscopy; the gas phase, matrix-assisted laser desorption ionization mass spectrometry was employed. In dioxane, absorption spectra of P present unique band with maxima at 361 392 nm, which associated monomer...
Abstract Invited for this month's cover picture is the BIOSCOPE group of Professors Carlos Lodeiro and José Luis Capelo at REQUIMTE/UCIBIO‐LAQv‐FCT University NOVA Lisbon (Portugal), their collaborators. The devoted to Translational Research, shows Portuguese Flag represented by interaction between cells Janus gold/silver nanoparticles functionalized with rhodamine (red) Fluorescein (green) dyes as tools biomedical translational research. Read full text Review 10.1002/open.201700135 .
Reaction between 2,6-bis(2-formylphenoxymethyl)pyridine and N,N-bis(3-aminopropyl)methylamine or tris(2-aminoethyl)amine has been used as the starting point for synthesis of seven oxa-aza macrocyclic ligands, five them never reported previously. They all feature different pendant arms, which provide a wide range coordination possibilities. The Schiff base macrocycles L 1 4 their reduced ligands 2 5 are derived from N,N-bis(3-aminopropyl)methylamine, respectively. reaction with...
Non-viral gene delivery using exogenous microRNAs is a potential strategy for fighting cancers with poor prognosis and which lack specific therapies, such as triple-negative breast cancer (TNBC). Herein we report the synthesis of six nontoxic electrostatic polymeric nanocapsules (P1 to P6) microRNA in TNBC cells. 1H Nuclear Magnetic Resonance (NMR) spectroscopy Scanning Electron Microscopy (SEM) were used characterize nanopolyplexes, synthesized Poly(L-Lysine) hyaluronic acid (Ha). Studies...
The lectin found in the tubers of Winter Aconite (Eranthis hyemalis) plant is an N-acetyl-D-galactosamine specific Type II Ribosome Inactivating Protein (RIP); RIPs have shown anti-cancer properties, and hence potential as therapeutic agents. Here we present a modified protocol for extraction purification E. hyemalis (EHL) using affinity chromatography. De novo amino acid sequencing EHL confirms its classification Protein. biocidal properties been investigated against nematode Caenorhabditis...
Long-term preservation of the properties gold nanoparticles in both solution and dry powder form can be difficult. We have overcome this challenge by using organotellurium derivatives as reducing agents stabilizers synthesis nanoparticles. This new synthetic protocol takes advantage photochemical oxidative diphenyl ditelluride (Ph2Te2), which, so far, never been exploited The Au/Te core/shell (inorganic/organic) hybrid nanomaterial obtained a one-step reaction, only Ph2Te2 HAuCl4. By...
Cyanine derivatives 1–3 were successfully characterized and their sensorial ability studied against Zn2+, Co2+, Cd2+, Ni2+, Cu2+, Hg2+ Ag+ metal ions. All dyes revealed a colourimetric selectivity towards Cu2+ ions, with the formation of mononuclear species. 2 can detect quantify lowest concentrations in aqueous media, 0.3 0.6 μM. With aim exploring optical properties these dyes, solid-supported devices designed by synthesis polymethylmethacrylate (PMMA) polymers doped 1, 2, 3 copper...
The lectin found in the tubers of Winter Aconite (Eranthis hyemalis) plant (EHL) is a Type II Ribosome Inactivating Protein (RIP). RIPs have shown anti-cancer properties and great potential as therapeutic agents. Similarly, colloidal gold nanoparticles are successfully used biomedical applications they can be functionalised with ligands high affinity specificity for target cells to create imaging Here we present synthesis characterization conjugated EHL results set initial assays establish...
Abstract Mononuclear macrocyclic complexes of manganese( II ), cobalt( ) and nickel( perchlorate using 10 different oxaazamacrocyclic ligands (L 1 — L have been prepared characterized. The complexation reactions with the diiminic were obtained by template condensation appropriate dialdehyde diamine precursors; reduced macrocycle synthesized a direct route. characterized elemental analyses, molar conductivity, mass spectrometry, IR, UV‐vis spectroscopy, diffuse reflectance magnetic...
Lectin are proteins which play an important role in the defence mechanisms of plants against attack microorganisms and insects: this has provoked particular interest -elds biotechnology agriculture. ;is paper describes extraction puri-cation lectin found tubers winter aconite (Eranthis hyemalis), with aim improving modernising existing protocol. ;e Eranthis hyemalis (EHL) is a member type-2 Ribosome Inactivating Proteins (RIP) family, have ability to inhibit vitro protein synthesis. RIPs...
Web 2.0 tools are changing the way we work online. As lecturers, need to understand how these emerging technologies impact both on our students’ learning and own teaching practice. This means must ourselves become more confident in use of 2.0, be able cope with rapidly nature technologies. In most cases technical infrastructure is already place, but this not enough. Unless lecturers given sufficient support encouragement at an institutional level, will follow VLE pattern rapid shallow...