A5028711772- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- Pancreatic and Hepatic Oncology Research
- Artificial Intelligence in Healthcare and Education
- Cancer Cells and Metastasis
- Privacy-Preserving Technologies in Data
- AI in cancer detection
- Metastasis and carcinoma case studies
- Colorectal Cancer Surgical Treatments
- Biomedical and Engineering Education
- Innovations in Medical Education
- Intestinal and Peritoneal Adhesions
- Colorectal Cancer Screening and Detection
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Viral-associated cancers and disorders
- Intraperitoneal and Appendiceal Malignancies
- Esophageal and GI Pathology
- Radiomics and Machine Learning in Medical Imaging
- Radiology practices and education
University of Leeds
2017-2024
Leeds Teaching Hospitals NHS Trust
2021-2024
St James's University Hospital
2019-2020
Artificial intelligence (AI) has a multitude of applications in cancer research and oncology. However, the training AI systems is impeded by limited availability large datasets due to data protection requirements other regulatory obstacles. Federated swarm learning represent possible solutions this problem collaboratively models while avoiding transfer. these decentralized methods, weight updates are still transferred aggregation server for merging models. This leaves possibility breach...
Endoscopic mucosal biopsies of primary gastric cancers (GCs) are used to guide diagnosis, biomarker testing and treatment. Spatial intratumoural heterogeneity (ITH) may influence biopsy-derived information. We aimed study ITH GCs matched lymph node metastasis (LNmet).GC resection samples were annotated identify tumour superficial (PTsup), deep (PTdeep) LNmet subregions. For each subregion, we determined (1) transcriptomic profiles (NanoString 'PanCancer Progression Panel', 770 genes); (2)...
Due to the Covid-19 social distancing restrictions, in March 2020, Weill Cornell Medicine-Qatar decided replace students' clinical instruction with novel online electives. Hence, we implemented an innovative and remote pathology curriculum, anchored on virtual microscopy Zoom videoconferencing: ideal tools support teaching.To assess a new curriculum implementation at Medicine-Qatar.This for-credit, 2-week elective included 6 synchronous sessions where complex clinicopathological cases were...
Neoadjuvant chemotherapy (NAC) remains an important therapeutic option for advanced oesophageal cancer (OC). Pathological tumour regression grade (TRG) may offer additional information by directing adjuvant treatment and/or follow-up but its clinical value unclear. We analysed the prognostic of TRG and associated pathological factors in OC patients enrolled Medical Research Council (MRC) OE02 trial.
The biological importance of tumour-associated stroma is becoming increasingly apparent, but its clinical utility remains ill-defined. For stage II/Dukes B colorectal cancer (CRC), biomarkers are urgently required to direct therapeutic options. We report here prognostic/predictive analyses, and molecular associations, stromal morphometric quantification in the Quick Simple Reliable (QUASAR) trial CRC.Relative proportions tumour epithelium (PoT) or (PoS) were morphometrically quantified on...
Beta2-microglobulin (B2M) forms part of the HLA class I complex and plays a role in metastatic biology. B2M mutations occur frequently mismatch repair-deficient colorectal cancer (dMMR CRC), with limited data suggesting they may protect against recurrence. Our experimental study tested this hypothesis by investigating mutation status protein expression recurrence patients stage II QUASAR clinical trial.Sanger sequencing was performed for three coding exons on 121 dMMR subsample 108 pMMR...
We hypothesized that the relative proportion of tumor (PoT) at luminal surface can predict gastric cancer (GC) patient survival. measured PoT in resection specimens from 231 GC patients with stage II/III disease who had surgery Kanagawa Cancer Center, Yokohama, Japan. Tissue microarrays were used to assess extent immune cell infiltration by CD45 immunohistochemistry. Results related histopathological features and overall survival (OS). was significantly lower diffuse-type (30%) compared...
Patients with Epstein-Barr virus-positive gastric cancers or those microsatellite instability appear to have a favourable prognosis. However, the prognostic value of chromosomal status (chromosome-stable (CS) versus instable (CIN)) remains unclear in cancer.Gene copy number aberrations (CNAs) were determined 16 CIN-associated genes retrospective study including test and validation cohorts patients cancer. stratified into CS (no CNA), CINlow (1-2 CNAs) CINhigh (3 more CNAs). The relationship...
Adenocarcinoma with more than 50% extracellular mucin is a relatively rare histological subtype of gastrointestinal adenocarcinomas. The clinical impact in oesophageal adenocarcinoma (OeAC) has not been investigated detail. We hypothesised that patients mucinous OeAC (OeACmucin) do benefit from neoadjuvant chemotherapy.OeAC either treated by surgery alone the OE02 trial (S-patients) or chemotherapy followed (CS-patients) OE05 trials were included. Cancers 1055 resection specimens (OE02 [test...
sign 74 Liver metastases 132 -resection 143 Local control 118 Locally advanced colorectal cancer 96 Lynch syndrome 39 Magnetic resonance 60 Mesalamine 55 MicroRNA 9 Microsatellite instability 27 miR-21 Abdominoperineal