Heat stress (HS) jeopardizes intestinal barrier functions and augments permeability in pigs. However, whether HS-induced maternal microbial metabolic changes primiparous sows during late gestation remains elusive. We present here, a study investigating the fecal responses gestational when exposed to HS.Twelve first-parity Landrace × Large White F1 were randomly assigned into two environmental treatments including thermoneutral (TN) (18-22 °C; n = 6) HS (28-32 conditions. Both applied from 85...

Unabsorbed copper accumulates in the hindgut of pigs that consume high levels dietary copper, which enhances coselection antibiotic-resistant bacteria and is considered detrimental to environment porcine health. In our study, a combination 16S rRNA pyrosequencing nontargeted metabolomics was used investigate microbiome-metabolome responses suckling piglets. The results showed level affected abundance several Clostridia genera relative butyrate-producing bacteria, such as Coprococcus,...

Mycotoxins, such as deoxynivalenol (DON), zearalenone (ZEN), and aflatoxin (AF), are commonly found in many food commodities may impair the growth reproductive efficiency of animals humans. We investigated effects a mycotoxin-contaminated diet on mouse oocyte quality. Maize contaminated with DON (3.875 mg/kg), ZEN (1,897 μg/kg), AF (806 μg/kg) was incorporated into at three different levels (0, 15, 30% w/w). After 4 weeks, ovarian germinal vesicle indices decreased mycotoxin-fed mice....

Abstract A stochastic model predictive control (MPC) framework is presented in this paper for nonlinear affine systems with stability and feasibility guarantee. We first introduce the concept of Lyapunov–Barrier function (CLBF) provide a method to construct CLBF by combining an unconstrained Lyapunov (CLF) barrier functions. The CLF obtained from its corresponding semi‐linear system through dynamic feedback linearization. Based on constructed CLBF, we utilize sampled‐data MPC deal states...

The objective of the current experiment was to explore intestinal microbiota ecological response oral administrations hydrogen-rich water (HRW) and lactulose (LAC) in female piglets fed a Fusarium mycotoxin-contaminated diet. A total 24 individually-housed (Landrace × large white; initial average body weight, 7.25 ± 1.02 kg) were randomly assigned receive four treatments (six pigs/treatment): uncontaminated basal diet (negative control, NC), (MC), MC + HRW (MC HRW), LAC LAC) for 25...

Following the intake of Fusarium mycotoxin-contaminated feed, small intestines may be exposed to high levels toxic substances that can potentially damage intestinal functions in livestock. It is well known mycotoxins will lead a breakdown normally impeccable epithelial barrier, resulting development "leaky" gut. H2 administration with different methods has been proved definitely potentials prevent serious diseases. The goal this study investigate roles lactulose (LAC) and hydrogen-rich water...

Lactulose as an effective prebiotic protects intestinal mucosal injury. Bacillus coagulans is widely used in feed additives because of its ability to promote health. Our previous study suggests that the combination lactulose and may be a good candidate alternative for antibiotic growth promoters. However, vivo effects on health under immune challenge piglets remains unclear. The objective this explore protective synbiotic containing injury barrier dysfunction weaned piglets. Twenty four were...

The objective of the current experiment was to evaluate whether hydrogen-rich water (HRW) or lactulose (LAC) could protect against adverse effects Fusarium mycotoxins-contaminated diet on growth performance and antioxidant status in weaning piglets. A total 24 individually housed female piglets were randomly assigned receive four treatments for 25 days (six pigs/treatment): uncontaminated basal (negative control), mycotoxin-contaminated (MC) diet, MC + HRW (MC HRW) LAC LAC). plasma hydrogen...

Rice bran is a high-quality and renewable livestock feed material rich in nutrients bioactive substances. To investigate the effects of dietary supplementation with fermented heat-treated rice on performance, apparent digestibility nutrients, cecal microbiota metabolites laying hens, total 128 18-week-old Hy-Line brown layers were randomly assigned to four treatment groups: 2.5% HRB (basal diet contained bran), 5.0% (5.0% FHRB (2.5% bran). Results showed that significantly increased average...

Equol, one of the intestinal microflora metabolites daidzein, has gained much attention for having greater bioactivity than its precursor (daidzein and daidzin) seeming to be promoted by hydrogen gas. The effects lactulose on equol-producing capacity liver antioxidant status barrows treated with daidzein were investigated in this study. Male castrated piglets (barrows) Landrace×Duroc, aged 40 days, randomly divided into following three groups: control group (C, n = 12, fed an...

To explore the protective role of hydrogen gas (H2) on oxidative damage and apoptosis in intestinal porcine epithelial cells (IPEC-J2) induced by deoxynivalenol (DON), were assigned to four treatment groups, including control, 5 μM DON, H2-saturated medium, DON + medium treatments. After 12 h different treatments, cell viability, biomarkers redox states, gene expression antioxidant enzymes observed detected. Furthermore, caspase-3 Bax protein expressions measured Western blot analysis. Our...

As global warming intensifies, emerging evidence has demonstrated high ambient temperature during pregnancy negatively affects maternal physiology with compromised pregnant outcomes; however, little is known about the roles of gut microbiota and its underlying mechanisms in this process. Here, for first time, we explored potential involved disrupted glycolipid metabolism via hepatic mitochondrial function. Our results indicate heat stress (HS) reduces fat protein contents serum levels...

High ambient temperature-induced heat stress (HS) during pregnancy may affect the placental function and fetal development. Late gestation is a critical period of developing brain intestine. The study aimed to investigate effects HS late on placenta, intestine in mouse model. We found that number stillborn mice were increased due maternal HS. Transcriptome analysis revealed expression genes enriched nutrients transport metabolism group up-regulated but down-regulated duodenum jejunum....

In this paper, we investigated the effects of a diet with moderate reduction dietary crude protein (CP) level, supplemented five crystalline amino acids (Lys, Met, Thr, Try, and Val), on growth, metabolism, fecal microbiota Sushan nursery pigs. Seventy pigs an average body weight 19.56 ± 0.24 kg were randomly allocated to two experimental treatments: 18% CP (high protein; group HP), 15% (low LP). We found that differences in diets had no significant effect growth performance Nursery showed...

The placenta is critical for the regulation of fetal innate immune function. Maternal heat stress (HS) impairs function and intestinal barrier in offspring. However, effects maternal HS on placental response development intestine its system remain unclear. Fetal mice were divided into utero control (IUTN) (IUHS) groups according to ambient temperature. Transcriptome analysis revealed that expressions response-related genes such as macrophage antigen CD68 Fc gamma receptors 1 3 (fcgγ1 fcgγ3)...