A5048033264- Reproductive Biology and Fertility
- Mycotoxins in Agriculture and Food
- Genetic Mapping and Diversity in Plants and Animals
- Milk Quality and Mastitis in Dairy Cows
- Estrogen and related hormone effects
- MicroRNA in disease regulation
- TGF-β signaling in diseases
- Molecular Biology Techniques and Applications
- Renal and related cancers
- Meat and Animal Product Quality
- Genetic and phenotypic traits in livestock
- Cancer-related molecular mechanisms research
- Immune Response and Inflammation
- Cancer Risks and Factors
- Probiotics and Fermented Foods
- Animal Genetics and Reproduction
- Mycobacterium research and diagnosis
- Machine Learning in Bioinformatics
- Human-Animal Interaction Studies
- Animal Behavior and Welfare Studies
- Animal Diversity and Health Studies
- Sphingolipid Metabolism and Signaling
- Wnt/β-catenin signaling in development and cancer
- Mechanisms of cancer metastasis
- Menstrual Health and Disorders
Nanjing Agricultural University
2008-2022
Xuzhou Medical College
2013-2021
Anhui University of Science and Technology
2013
Anhui Science and Technology University
2013
Wen's Food Group (China)
2010
Proteomics and bioinformatics may help us better understand the biological adaptations occurring during bovine mastitis. This systems approach also could identify biomarkers for monitoring clinical subclinical The aim of present study was to use isobaric tags relative absolute quantification (iTRAQ) screen potential proteins associated with mastitis at late infectious stage. Healthy mastitic cows’ mammary gland tissues were analyzed using iTRAQ combined two-dimensional liquid...
To investigate the correlation between level of circulating vitamin D and development colorectal cancer (CRC) to clarify effect mechanism on CRC.Serum samples from 63 patients with CRC (CRC group) 61 healthy volunteers (normal were collected. Azoxymethane + dextran sodium sulfate-induced mouse model dietary models different doses established verify whether supplementation could reverse occurrence at overall animal level. Intestinal barrier integrity microbial defense response evaluated by...
Zearalenone (ZEN) is a metabolite of Fusarium and common contaminant grains foodstuffs. ZEN acts as xenoestrogen considered to be cytotoxic, tissue toxic, genotoxic, which causes abortions stillbirths in humans animals. Since estrogens affect oocyte maturation during meiosis, this study we investigated the effects on mouse meiotic granulosa cell proliferation. Our results showed that ZEN-treated rates were decreased, might due disrupted cytoskeletons: (1) treatment resulted significantly...
Mycotoxins, such as deoxynivalenol (DON), zearalenone (ZEN), and aflatoxin (AF), are commonly found in many food commodities may impair the growth reproductive efficiency of animals humans. We investigated effects a mycotoxin-contaminated diet on mouse oocyte quality. Maize contaminated with DON (3.875 mg/kg), ZEN (1,897 μg/kg), AF (806 μg/kg) was incorporated into at three different levels (0, 15, 30% w/w). After 4 weeks, ovarian germinal vesicle indices decreased mycotoxin-fed mice....
Zearalenone (ZEA) is a nonsteroidal estrogenic mycotoxin produced mainly by Fusarium. ZEA causes reproductive disorders and both cytotoxic genotoxic in animals; however, little known regarding the molecular mechanism(s) leading to toxicity. Sertoli cells are somatic that support development of spermatogenic cells. The objective this study was explore effects on proliferation, apoptosis, necrosis rat uncover signaling pathways underlying cytotoxicity. reduced proliferation dose-dependent...
FSH plays a critical role in granulosa cell (GC) proliferation and steroidogenesis through modulation by factors including bone morphogenetic proteins family, which belongs to transforming growth factor β (TGFB) superfamily. TGFBs are the key maintaining differentiation ovaries. However, interaction of TGFB on GCs' remains be elucidated. In this study, we have investigated SMAD4, core molecule mediating intracellular TGFB/SMAD signal transduction pathway, FSH-mediated porcine GCs. SMAD4 was...
Intramuscular fat (IMF) content plays a key role in establishing pork quality.In the present study, differential-display reverse transcription-polymerase chain reaction (DDRT-PCR) was used to identify differentially expressed (DE) genes between longissimus dorsi (LD) muscles with extremely different IMF content.A major DE gene associated identified as splicing factor serine-arginine rich protein (SFRS18) gene, also known SRrp130.The exhibited relatively higher expression levels LD...
Type 2 diabetes mellitus (T2DM) is thought to be a risk factor for endometrial hyperplasia, but potential links between the two diseases are unknown. This study aims evaluate role of T2DM in progression hyperplasia.Female Sprague-Dawley rats were randomly divided into normal (N) group, hyperplasia (NH) (T) and with (TH) group. Proteomics analysis was performed determine protein profile tissues. Proliferation, migration, invasion cells with/without GLANT2-knockdown assessed....
Because zearalenone (ZEA) causes harmful influence to animals and widely exists in the world, researches on ZEA have never stopped. However, mechanisms of proliferation, cycle, apoptosis endometrial stromal cells (ESCs) remain poorly defined. Therefore, purpose our study was explore effects ESCs demonstrate them by transcriptomic analysis. The results showed that after treatment, appeared numerous adverse reactions, phenomena cell viability decrease, DNA replication block were detected flow...
Abstract Background Multiple common variants identified by genome-wide association studies have shown limited evidence of the risk breast cancer in Chinese individuals. In this study, we aimed to uncover relationship between estrogen levels and genetic polymorphism metabolism-related enzymes (BC) establish a prediction model composed estrogen-metabolizing enzyme genes GWAS-identified cancer-related based on polygenic score. Methods Unrelated BC patients healthy subjects were recruited for...
Stathmin 1 (STMN1) is a neuronal growth-associated protein that involved in microtubule dynamics and plays an important role synaptic outgrowth plasticity. Given STMN1 affects fear behavior, we hypothesized genetic variations the transcriptional regulatory region affect gene transcription activity control behavior. In this study, two single nucleotide polymorphisms (SNPs), g. -327 A>G -125 C>T, were identified 317 English Springer Spaniels. A bioinformatics analysis revealed both loci...
Gpr3, a member of the G protein-coupled receptor superfamily, was known as critical factor for maintenance meiotic prophase arrest in oocytes via Gs protein-mediated pathway. The present studies were conducted to examine ovarian immunolocalization its expression pattern different stages fetal, postnatal and developmental pigs effect on proliferation granulosa cells pigs. Immunohistochemical analysis indicated that Gpr3 localized egg nests, (GCs) follicle ranging from primordial Graafian...