A5102856784- Anesthesia and Pain Management
- Cardiac, Anesthesia and Surgical Outcomes
- Nausea and vomiting management
- Anesthesia and Sedative Agents
- Estrogen and related hormone effects
- Hemodynamic Monitoring and Therapy
- Spine and Intervertebral Disc Pathology
- Tracheal and airway disorders
- Natural product bioactivities and synthesis
- Airway Management and Intubation Techniques
- Thermal Regulation in Medicine
- Metabolomics and Mass Spectrometry Studies
- Abdominal Surgery and Complications
- Thermoregulation and physiological responses
- Infrared Thermography in Medicine
- Pediatric Pain Management Techniques
- Pain Mechanisms and Treatments
- Sepsis Diagnosis and Treatment
- Menopause: Health Impacts and Treatments
- Healthcare and Venom Research
- Bioactive Compounds and Antitumor Agents
- Phytoestrogen effects and research
- Anesthesia and Neurotoxicity Research
- Advanced Proteomics Techniques and Applications
- Ginseng Biological Effects and Applications
Hallym University
2000-2024
Hallym University Kangnam Sacred Heart Hospital
2014-2024
Tokyo University of Agriculture and Technology
2024
Hallym Polytechnic University
2021
University of Toledo
2017
University of Toyama
2007-2010
Nanjing University
2010
ABSTRACT Lipidomics and metabolomics communities comprise various informatics tools; however, software programs that can handle multimodal mass spectrometry (MS) data with structural annotations guided by the Standards Initiative are limited. Here, we provide MS-DIAL 5 to facilitate in-depth elucidation of lipids through electron-activated dissociation (EAD)-based tandem MS, as well determine their molecular localization MS imaging (MSI) using a species/tissue-specific lipidome database...
Abstract Lipidomics and metabolomics communities comprise various informatics tools; however, software programs handling multimodal mass spectrometry (MS) data with structural annotations guided by the Standards Initiative are limited. Here, we provide MS-DIAL 5 for in-depth lipidome elucidation through electron-activated dissociation (EAD)-based tandem MS determining their molecular localization imaging (MSI) using a species/tissue-specific database containing predicted collision-cross...
BACKGROUND Peri-operative hypothermia and shivering are frequent events in patients during caesarean delivery under spinal anaesthesia. OBJECTIVE We assessed the efficacy of combined pre-anaesthetic forced-air warming combination with warmed intravenous fluid infusion for preventing DESIGN A randomised controlled study. SETTING tertiary care teaching hospital from July 2017 to April 2018. PATIENTS total 50 pregnant women, American Society Anaesthesiologists physical status 2, aged 20 45...
Glycyrrhiza uralensis, known for its diverse pharmacological effects, including immunoregulation, anti-tumor, and antioxidant properties, is a widely used medicinal plant found in more than 70% of traditional herbal medicines (Kampo) Japan. Although over 300 compounds have been discovered G. the molecular mechanisms underlying bioactivity remain largely unknown due to chemical diversity compounds. Here, we performed multiomics analysis incorporating untargeted hydrophilic metabolomics,...
Through an estrogenic activity bioassay-guided fractionation of the 70% ethanolic extract Cassia tora seeds two new phenolic triglucosides, torachrysone 8-O-[β-D-glucopyranosyl(1→3)-O-β-D-glucopyranosyl(1→6)-O-β-D-glucopyranoside] (1) and toralactone 9-O-[β-D-glucopyranosyl-(1→3)-O-β-D-glucopyranosyl-(1→6)-O-β-D-glucopyranoside] (2), along with seven known compounds were isolated. The structures elucidated on basis spectroscopic chemical evidence. fractions isolated investigated using...
Phloridzin, a phloretin 2′-β-D-glucoside, belongs to dihydrochalcones and mainly exists in the fruits of Malus pumila Mill., Lithocarpus polystachyus REHD root skins, stems, tender leaves hupehensis. It has many pharmacological activities, such as regulating blood sugar level pressure, protecting heart, scavenging oxygen free radicals antioxidant injuries. Thus, market demand products containing phloridzin is increasing year by year. Our research results demonstrated that provided with...
Remifentanil is a short-acting drug with rapid onset that useful in general anesthesia. Recently, however, it has been suggested the use of opioids during surgery may cause opioid-induced hyperalgesia (OIH). Researchers have recently reported esmolol, an ultra-short-acing β1 receptor antagonist, reduces postoperative requirement for morphine and provides more effective analgesia than administration remifentanil ketamine. Hence, this study was conducted to determine whether esmolol early pain...
The purpose of this study is to assess whether the application preoperative forced air warming set high temperature (> 43 °C) for brief period can increase on admission postanesthesia care unit (PACU) and prevent hypothermia or shivering during holmium laser enucleation prostate performed under spinal anesthesia. Fifty patients were enrolled assigned randomly receive passive insulation (control group, n = 25) forced-air skin surface 20 min before anesthesia (pre-warming 25). primary outcome...
Capillary electrophoresis coupled with tandem mass spectrometry (CE-MS/MS) offers advantages in peak capacity and sensitivity for metabolic profiling owing to the electroosmotic flow-based separation. However, utilization of data-independent MS/MS acquisition (DIA) is restricted due absence an optimal procedure analytical chemistry its related informatics framework. We assessed spectral quality using two DIA techniques, namely, all-ion fragmentation (AIF) variable (vDIA), isolate 60–800 Da...
Female hormone-dependent cancers and other diseases pose a serious health threat for women, low-risk medicines against such have not yet been discovered. The present study examines the effects of traditional Chinese herbal mixture, Tokishakuyakusan (TS) 17β-estradiol on uterus parous ovariectomized rats. Uterine atrophy that causes reduction in uterine tissue cavity area, was induced by ovariectomy, slightly recovered daily oral administration TS two weeks (1000 mg/kg body weight). restored...
Background Epidrum® is a recently developed, air operated, loss of resistance (LOR) device for identifying the epidural space. We investigated usefulness by comparing it with conventional LOR technique Methods One hundred eight American Society Anesthesiologists (ASA) physical status I or II patients between ages 17 and 68 years old who were scheduled elective surgery under combined spinal-epidural anesthesia enrolled in this study. The randomized into two groups: one group received (C...
Background: While recovery from remifentanil is fast due to its rapid metabolism, it can induce hyperalgesia by activation of N-methyl-D-aspartic acid (NMDA) receptors.Therefore, administration NMDA receptor antagonists such as ketamine effective in relieving caused remifentanil.A previous study showed that nefopam before anesthesia combined with low-dose reduced pain and analgesic consumption during the immediate postoperative period.We hypothesized intraoperative infusion laparoscopic...
Through an anti-estrogenic bioassay-guided fractionation of the methanol extract Mansonia gagei, three new coumarins, called mansorins I (1), II (2) and III (3) a naphthoquinone, mansonone (4), were isolated. Their structures determined based on their NMR data CD spectroscopy. The activity fractions isolated compounds investigated using yeast two-hybrid assay method expressing estrogen receptors α (ERα) β (ERβ). In addition, ERα competitor screening system (ligand binding screen) was used to...
The naringinase-treated methanol extract of Sophora japonica L. (Fabaceae) seeds showed potent estrogen agonist activity. Through bioassay-guided isolation the main active constituents from S. japonica, aglycones genistein and kaempferol were found to be phytoestrogens in extract. In addition, was nearly equipotent as an agonist. Concerning compounds isolated untreated extract, sophoricoside weak estrogenic activity on ERbeta only.
The reliability of pulse pressure variation (PPV) and stroke volume (SVV) is controversial under pneumoperitoneum. In addition, the usefulness these indices being called into question with increasing adoption lung-protective ventilation using low tidal (VT) in surgical patients. A recent study indicated that changes PPV or SVV obtained by transiently VT (VT challenge) accurately predicted fluid responsiveness even critically ill patients receiving VT. We evaluated whether induced a challenge...
Despite the health risks for postmenopausal women, indications and ideal candidates hormone replacement therapy remain unclear. The present study used ovariectomized rats to examine safety effects of Chinese herbal formula Menoprogen (MPG), which is prescribed menopausal syndrome. Daily oral MPG (1000 mg/kg body weight) 2 weeks significantly recovered uterine adrenal gland atrophy restored serum estradiol, estrone progesterone levels that were decreased in by bilateral ovariectomy. However,...
We report on an anesthetic experience with a 74-year-old female Isaacs' syndrome, who underwent elective surgery for open rotator cuff repair. syndrome is rare peripheral motor neuron disorder clinical manifestations such as involuntary muscle twitching, cramps, mild weakness and increased sweating. To avoid prolonged neuromuscular blockade, the patient was observed monitoring during total intravenous anesthesia propofol, remifentanil, atracurium. No adverse events were management, recovered...
Background Bicarbonate, as an adjunct increasing the non-ionized form of local anesthetics, can reduce latency and prolong duration regional nerve block. Warming anesthetics decreases pKa also increases anesthetics. We warmed ropivacaine to body temperature (37℃) evaluated sensory block onset time, motor time analgesic axillary Methods Patients were consecutively allocated two groups 22 patients each. Ropivacaine 150 mg (30 ml) at 20℃ (room temperature) 37℃ (body was injected in group 1 2,...
Background and Objectives: Hip fracture surgery, which affects quality of life, can be a major challenge in geriatric populations. Although sarcopenia is known to associated with postoperative outcomes, there are few studies on the association between acute kidney injury (AKI) this population. We investigated AKI elderly patients following hip surgery. Materials Methods: retrospectively reviewed records who underwent surgery at our institution from March 2019 December 2021. Patients under...
BACKGROUND: Thermosoftening of the endotracheal tube (ETT) and telescoping ETT into a rubber catheter have been suggested as method for reducing epistaxis during nasotracheal intubation (NTI). However, thermosoftening technique is known to make it difficult navigate trachea without use Magill forceps NTI. The cuff inflation has an effective alternative improve oropharyngeal navigation ETT, irrespective their stiffness, direct laryngoscope-guided We evaluated whether telescoped catheters...
Mi Hyeon Lee, MD, Cheol Sig Han, Sang Hoon Jeong Hyun Eun Choi, Young Ryong and Hwa Chung, MD. Korean J Pain 2013;26:286-90. https://doi.org/10.3344/kjp.2013.26.3.286
Purpose:We aimed to determine whether head elevation during combined spinalepidural anesthesia (CSE) and Caesarean section provided improved hemodynamics appropriate sensory block height.Materials Methods: Forty-four parous women undergoing CSE for elective were randomly assigned one of two groups: right lateral (group L) or elevated HE) position, insertion the block.Patients positioned in supine wedged position left until a height T5 light touch was reached.Group HE then turned with...
Lung separation using a double-lumen endobronchial tube is necessary for video assisted thoracoscopy (VATs). Bronchial rupture after intubation with has been rarely reported. We report case of 70-year-old man who had solitary pulmonary nodule in his right upper lobe. He was intubated left-sided Robertshaw tube. underwent VATs lobectomy the one-lung ventilation left lung. During operation, mainstem bronchus detected. Immediately, thoracotomy performed and ruptured repaired absorbable sutures...