A5100732328- Geochemistry and Geologic Mapping
- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Antibiotic Resistance in Bacteria
- Geoscience and Mining Technology
- Retinoids in leukemia and cellular processes
- Inflammatory Bowel Disease
- Geological and Geochemical Analysis
- Geochemistry and Geochronology of Asian Mineral Deposits
- Gut microbiota and health
- Pneumocystis jirovecii pneumonia detection and treatment
- Biochemical and Molecular Research
- Geomechanics and Mining Engineering
- Bacterial biofilms and quorum sensing
- Microbial Natural Products and Biosynthesis
- High-Voltage Power Transmission Systems
- Inflammasome and immune disorders
- Ion Channels and Receptors
- Environmental Quality and Pollution
- Cardiac Fibrosis and Remodeling
- Botanical Research and Applications
- Curcumin's Biomedical Applications
- Cell death mechanisms and regulation
- Autophagy in Disease and Therapy
- ATP Synthase and ATPases Research
Academy of Military Medical Sciences
2024
Shanxi Medical University
2022-2024
Université Libre de Bruxelles
2019-2023
Tianjin University of Traditional Chinese Medicine
2023
Wuhan Botanical Garden
2021
Chinese Academy of Sciences
2021
Jilin University
2021
Shanghai University of Traditional Chinese Medicine
2010-2021
Shaanxi University of Science and Technology
2013-2019
Beijing Normal University
2017
Hypoxia‐induced apoptosis is linked to the pathogenesis of myocardial infarction (MI) and heart failure. Ubiquitin‐specific peptidase 7 (USP7) related catabolic/pro‐apoptotic signaling. However, its role in cardiomyocyte injury unclear. In this study, we aimed investigate underlying regulatory mechanism USP7 MI. H9c2 cardiomyocytes were cultured hypoxia establish an vitro model hypoxic/ischemic injury. Sprague‐Dawley (SD) rats used animal models with Quantitative real‐time polymerase chain...
Although the incidence of ulcerative colitis (UC) increases every year, there is still a lack satisfactory treatment options. Anemone chinensis Bunge (AB), traditional Chinese herb, potent compound that can be prepared as decoction, and then administered an enema to relieve UC symptoms. However, therapeutic effect mechanisms aqueous AB on are unknown.This study investigates potential value mechanism for UC.First, practical components in were extracted identified by UPLC-MS/MS. Second, active...
The N-hydroxydodecanamide (HA12) and its complexes tri-hydroxamato-iron(III) di-hydroxamto-iron(III) chloride (HA8Fe3 HA12Fe3Cl, respectively) showed antibacterial antimycobacterial activities. proteomic analysis demonstrated that the targets of Hydroxamic Acid (HA) their were involved in biosynthesis mycobacterial cell walls. Reactive Oxygen Species (ROS) is one key elements to cause oxidative stress, damaging DNA, membranes impaired during procedure kill bacteria. Here, ROS production was...
Biofilm formation is a survival strategy for microorganisms facing hostile environment. Under biofilm, bacteria are better protected against antibacterial drugs and the immune response, increasing treatment difficulty, as persistent populations recalcitrant to chemotherapy promoted. Deciphering mechanisms leading biofilms could, thus, be beneficial obtain new drug candidates. Here, we show that mycobacterial biofilm linked excess glycerol adaptation concomitant establishment of Crabtree...
Hydroxamic acid (HA) derivatives display antibacterial and antifungal activities. HA with various numbers of carbon atoms (C2, C6, C8, C10, C12 C17), complexed different metal ions, including Fe(II/III), Ni(II), Cu(II) Zn(II), were evaluated for their antimycobacterial activities anti-biofilm Some showed activities, especially in biofilm growth conditions. For example, 20-100 µM HA10Fe2, HA10FeCl, HA10Fe3, HA10Ni2 or HA10Cu2 inhibited Mycobacterium tuberculosis, bovis BCG marinum...
Abstract The recalcitrance of pathogenic Mycobacterium tuberculosis, the agent to eradication is due various factors allowing bacteria escape from stress situations. mycobacterial chaperone GroEL1, overproduced after macrophage entry and under oxidative stress, could be one these key players. We previously reported that GroEL1 necessary for biosynthesis phthiocerol dimycocerosate, a virulence-associated lipid reducing antibiotic susceptibility. In present study, we showed bearing unique...
Phosphoribosyl-ATP pyrophosphohydrolase is the second enzyme in histidine-biosynthetic pathway, irreversibly hydrolyzing phosphoribosyl-ATP to phosphoribosyl-AMP and pyrophosphate. It encoded by hisE gene, which present as a separate gene many bacteria archaea but fused hisI other bacteria, fungi plants. Because of its essentiality for growth vitro, HisE potential drug target tuberculosis. The crystal structures two native (uncomplexed) forms from Mycobacterium tuberculosis have been...
Phthiocerol dimycocerosates and phenolic glycolipids (PGL) are considered as major virulence elements of Mycobacterium tuberculosis , in particular because their involvement cell wall impermeability drug resistance. The biosynthesis these waxy lipids involves multiple enzymes, including thioesterase A (TesA). We observed that purified recombinant M. TesA is able to dimerize the presence palmitoyl‐CoA our 3D structure model with this acyl‐CoA suggests hydrophobic interaction requirement for...
Composite Fe3O4/Au nanoparticles are attracting considerable interest in developing visual and specific detection of biomolecular due to their unique physical chemical properties. Here, two localize surface plasmon resonance (LSPR) probes based on (nanoSPR biosensors) were fabricated by exploring 11-mercaptoundecanoic acid (MUA) poly acrylic (PAA) as modification agents subsequently conjugating rabbit IgG with the modified particles' surface. Comparative investigations showed differences...
Background: The traditional Chinese medicine formula ErLong ZuoCi (ELZC) has been extensively used to treat age-related hearing loss (ARHL) in clinical practice China for centuries. However, the underlying molecular mechanisms are still poorly understood. Objective: Combine network pharmacology with experimental validation explore potential ELZC a systematic viewpoint. Methods: chemical components of were collected from Traditional Medicine System Pharmacology database, and their possible...
<title>Abstract</title> Background: The relationship between primary tumor volume (PTV) and overall survival (OS) in patients with human epidermal growth factor receptor 2 (HER-2)-positive breast cancer following Ttrastuzumab therapy remains controversial the medical research community. Currently, there is insufficient evidence to definitively establish PTV OS; understanding this critical for healthcare public health because it has significant implications patient outcomes. Consequently, its...
Orefield structures of Fankou lead-zinc deposit in Guangdong province is complex and have been argued about for years. On the basis theory method geomechanics, mechanics features structural planes orefield identified. Its indicated that its structure divided into three types systems, is, northwest trending belt which origin from Caledonian stage to Hercynian stage, Lambda-type Indo-Chinese Yanshan eastweat Himalayan stage. The lambda-type made major fault F 203 strike branch 3 , 4...