A5062046660- Pharmacological Effects of Medicinal Plants
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Natural product bioactivities and synthesis
- Crystallography and molecular interactions
- Synthetic Organic Chemistry Methods
- Monoclonal and Polyclonal Antibodies Research
- Plant-derived Lignans Synthesis and Bioactivity
- RNA Interference and Gene Delivery
- Traditional Chinese Medicine Analysis
- Phytochemistry and Biological Activities
- Synthesis of Organic Compounds
- Bone Metabolism and Diseases
- Bioactive natural compounds
- Bioactive Compounds and Antitumor Agents
- Traditional and Medicinal Uses of Annonaceae
- Inflammatory mediators and NSAID effects
- Drug Transport and Resistance Mechanisms
- Ethnobotanical and Medicinal Plants Studies
- Therapeutic Uses of Natural Elements
- SARS-CoV-2 detection and testing
- Animal Virus Infections Studies
- SARS-CoV-2 and COVID-19 Research
- Peroxisome Proliferator-Activated Receptors
- Nanoparticle-Based Drug Delivery
National Vaccine and Serum Institute
2022-2024
Guizhou University
2024
Beijing Radiation Center
2021-2022
Institute of Microbiology
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2019
Shanxi University
2019
Thomas Jefferson University
2014
Eight new cembranoids, boscartins A–H (1, 2, and 4–9), the known incensole oxide were isolated from gum resin of Boswellia carterii. The absolute configurations 1, 4, unequivocally resolved using single-crystal X-ray diffraction analysis with Cu Kα radiation, configuration 5 was via electronic circular dichroism data. antiulcerative colitis activities compounds evaluated in an vitro x-box-binding protein 1 (XBP 1) transcriptional activity assay dual luciferase reporter detection. At 10 μM,...
Chemical examination of the exuded gum resin Boswellia carterii resulted in isolation nine new prenylaromadendrane-type diterpenes, boscartols A-I (1-9). The structures these compounds were established by extensive 1D and 2D NMR spectroscopic analyses, mass spectrometric data, circular dichroism spectra. Compounds 1-3, 5, 6, 8, 9 (10 μM) showed moderate hepatoprotective activity against d-galactosamine-induced HL-7702 cell damage.
Abstract The extreme instability of mRNA makes the practical application mRNA‐based vaccines heavily rely on efficient delivery system and cold chain transportation. Herein, a DNA‐based nanomachine, which achieves programmed capture, long‐term storage without cryopreservation, in cells, is developed. polythymidine acid (Poly‐T) functionalized poly( N ‐isopropylacrylamide) (DNA‐PNIPAM) synthesized assembled as central compartment nanomachine. DNA‐PNIPAM nano‐assembly exhibits reversible...
Triptolide is a major active ingredient isolated from the traditional Chinese herb Tripterygium wilfordii Hook F. However, its use in clinical practice limited due to severe hepatotoxicity. Autophagy, highly conserved intracellular process, essential for maintaining cytoplasmic homeostasis. Considering that abnormalities autophagy are closely associated with drug-mediated hepatotoxicity, we applied human normal liver HL7702 cells elucidate roles of triptolide-induced Our study revealed...
Seven new dianthrone glycosides, named polygonumnolides A1-B3 (1-7), were isolated from the 70 % EtOH extract of dried roots Polygonum multiflorum Thunb. using column chromatography and preparative high-performance liquid chromatography. Their structures determined by 1D 2D NMR mass spectroscopy. The compounds evaluated for their cytotoxic effects against KB tumor cell lines 1-4 showed moderate cytotoxicity.
Two new prenylated phloroglucinol derivatives (1-2), and a known compound furohyperforim isomer 2 (3), were isolated from the aerial parts of Hypericum scabrum. Their structures elucidated by various spectroscopic methods, including MS, IR, UV, NMR.
A new dimeric phthalide, chaxiongnolide (1), and a natural product, B (2), together with known compound Z-ligustilide (3), were isolated from the rhizome of Ligusticum sinense Oliv cv. Chaxiong. Their structures elucidated by various spectroscopic methods confirmed X-ray crystallographic analysis.
Background and AimsPyrrolizidine alkaloids (PAs), widely distributed in plants, are known to induce liver failure. Hepatic platelet accumulation has been reported during the progression of PA-induced injury (PA-ILI). This study aimed investigate mechanisms underlying PA-ILI.