A5030924576- Cancer Genomics and Diagnostics
- Spaceflight effects on biology
- Molecular Biology Techniques and Applications
- Advanced Breast Cancer Therapies
- Pluripotent Stem Cells Research
- Cardiovascular Health and Risk Factors
- Mitochondrial Function and Pathology
- T-cell and B-cell Immunology
- High Altitude and Hypoxia
- Retinal Development and Disorders
- Lymphoma Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Immune Cell Function and Interaction
- CRISPR and Genetic Engineering
- Global Cancer Incidence and Screening
- Monoclonal and Polyclonal Antibodies Research
- Health, Environment, Cognitive Aging
- Protein Degradation and Inhibitors
- Ubiquitin and proteasome pathways
- Immunodeficiency and Autoimmune Disorders
- Genomics and Rare Diseases
- Pancreatic and Hepatic Oncology Research
Creative Commons
2023
Hampton University
2019-2020
Cancer Research Center
2019-2020
National Institute of Diabetes and Digestive and Kidney Diseases
2017-2018
National Institutes of Health
2017-2018
Duke Medical Center
2016
Duke University
2016
Sandhoff disease, one of the GM2 gangliosidoses, is a lysosomal storage disorder characterized by absence β-hexosaminidase A and B activity concomitant accumulation its substrate, ganglioside. It features catastrophic neurodegeneration death in early childhood. How ganglioside might affect development nervous system not understood. Recently, cerebral organoids derived from induced pluripotent stem (iPS) cells have illuminated developmental events altered disease processes. To develop an...
A systems biology approach was implemented utilizing NASA's GeneLab platform involving experiments from samples flown in space, human physiological data astronauts, and confirmation NASA Twin Study. comprehensive multi-omics correlating transcriptomics, proteomics, metabolomics, methylation analysis. We found that cells have stronger overall biological response than the tissues to spaceflight, with mitochondrial activity innate immunity pathways being heavily impacted. Study results are...
Abstract Pancreatic cancer is one of the most fatal all cancers. adenocarcinomas have been historically difficult to treat, in part due lack early detection, and their resistance conventional chemotherapy. There has recently an improved understanding biologic processes driving pancreatic tumorigenesis, increase clinical trial options available patients, especially context KRAS mutation positive ductal adenocarcinoma (PDAC). a known driver initiation, with concurrent loss TP53 many cases....
Drug Palbociclib Dose 75 mg/kg Route PO Schedule qd Duration of treatment 52 d Strain of mice Athymic Nude TGI (day) 59% (Day 52) p-value < 0.0001
Abstract Purpose: Minorities are often underrepresented in clinical cancer research and the frequency of reporting race genomic sequencing studies is unknown. Disproportionate can widen health information disparities impair decision-making minority populations whom disease burden greatest. This study determined extent to which reported as a variable United States, factors associated with race, participation rates populations. Methods: PubMed was systematically searched from January 1, 2010...
Purpose: Minorities are often underrepresented in clinical cancer research and the frequency of reporting race genomic sequencing studies is unknown. Disproportionate can widen health information disparities impair decision-making minority populations whom disease burden greatest. This study determined extent to which reported as a variable United States, factors associated with race, participation rates populations.Methods: PubMed was systematically searched from January 1, 2010 through...