A5051886920- Essential Oils and Antimicrobial Activity
- Natural Compound Pharmacology Studies
- Bee Products Chemical Analysis
- Plant Toxicity and Pharmacological Properties
- Sesquiterpenes and Asteraceae Studies
- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Carbohydrate Chemistry and Synthesis
- Insect and Pesticide Research
- Phytochemistry Medicinal Plant Applications
- Synthesis of Organic Compounds
- Polysaccharides and Plant Cell Walls
- Research on Leishmaniasis Studies
- Moringa oleifera research and applications
- Insect Pest Control Strategies
- Molecular spectroscopy and chirality
- Phytochemical Studies and Bioactivities
- Alkaloids: synthesis and pharmacology
- Phytochemicals and Antioxidant Activities
- Nanoparticles: synthesis and applications
- Protein Structure and Dynamics
- Metabolomics and Mass Spectrometry Studies
- Phytochemical compounds biological activities
- Ethnobotanical and Medicinal Plants Studies
- Phytochemistry and Bioactive Compounds
Universidade de São Paulo
2016-2023
Universidad Andina del Cusco
2023
National University of Saint Anthony the Abbot in Cuzco
2014-2023
Universidade de Ribeirão Preto
2022
Universidade Federal do Rio Grande do Sul
2013-2018
Abstract Gold nanoparticles (AuNPs) are highlighted due to their low toxicity, compatibility with the human body, high surface area volume ratio, and surfaces that can be easily modified ligands. Biosynthesis of AuNPs using plant extract is considered a simple, low-cost, eco-friendly approach. Brazilian Red Propolis (BRP), product bees, exhibits anti-inflammatory, anti-tumor, antioxidant, antimicrobial activities. Here, we described biosynthesis BRP (AuNP ) its fractions hexane , AuNP...
The Brazilian red propolis (BRP) constitutes an important commercial asset for northeast beekeepers. role of Dalbergia ecastaphyllum (L.) Taub. (Fabaceae) as the main botanical source this has been previously confirmed. However, in addition to isoflavonoids and other phenolics, which are present resin D. ecastaphyllum, samples BRP reported contain substantial amounts polyprenylated benzophenones, whose was unknown. Therefore, field surveys, phytochemical chromatographic analyses were...
Abstract The profile of secondary metabolites in ten members tribe Mentheae ( Nepetoideae , Lamiaceae ) from Peru by liquid chromatography associated with high resolution mass spectrometry, is presented. Salvianolic acids and their precursors were found, particularly rosmarinic acid, caffeic acid ester derivatives, as well a diversity free glycosylated flavonoids main substances. At all, 111 structures tentatively identified.
Propolis is one of the most widely used products in traditional medicine. One prominent types Brazilian propolis red one, whose primary botanical source Dalbergia ecastaphyllum (L.) Taub. Despite potential for developing new with pharmacological activity, few studies guarantee safety its use. The objective this study was evaluation possible toxic effects and D. ecastaphyllum, as well cytotoxicity assessment main compounds on tumoral cell lines. Hydroalcoholic extracts (BRPE) stems (DSE)...
Leishmaniasis has emerged as the third most prevalent parasite-borne disease worldwide after malaria and filariasis, with about 350 million people at risk of infection. Antileishmanial drugs currently available have various limitations, mainly because parasite resistance side effects. The search new antileishmanial is ventured throughout world.The purpose this study was to assess leishmanicidal activity lipophilic extracts eight Hypericum species against promastigote forms Leishmania...
A new dimeric acylphloroglucinol derivative, andinin (1), was isolated from the underground plant parts of Hypericum andinum, along with three known acylphloroglucinols, uliginosin (2), B (3), and isouliginosin (4). The structure 1 elucidated using 1D 2D NMR MS experiments by comparison previously reported data for acylphloroglucinols. Andinin (1) displayed antidepressant-like activity in a mouse forced-swimming test when administered orally at doses 3, 10, 30 mg/kg.
The occurrence of chromanone derivatives has been noticed as a distinctive feature the genus Calophyllum (Calophyllaceae). Previous studies have demonstrated that extract stem bark brasiliense and its chromanone-rich fractions show anti-ulcer activity in murine gastric ulcer models. In this work, brasiliensic isobrasiliensic acids, two main compounds n-hexane C. brasiliense, were isolated by flash chromatography using silica gel impregnated with silver nitrate their structures elucidated NMR...
Smallanthus sonchifolius (yacon) is an edible tuberous Andean shrub that has been included in the diet of indigenous people since before recorded history. The nutraceutical and medicinal properties yacon are widely recognized, especially for improvement hyperglycemic disorders. However, chemical diversity main bioactive series caffeic acid esters not explored detail. In this metabolomics study, we applied latest tools to facilitate targeted isolation new esters. Using liquid chromatography...
Propolis, produced by honey bees, is used around the world, displaying several corroborated biological activities. Brazil one of leading producers propolis, with a great diversity types, each characteristically chemical fingerprint influenced flora local region. The secondary metabolite's composition propolis strongly impacts its properties, and characterization importance for quality control. Several chromatographic techniques have been applied to characterize highlighting extraction...
Abstract Bioactive molecules isolated from plants are promising sources for the development of new therapies against leishmaniasis. We investigated leishmanicidal activity cariphenone A (1), isouliginosin B (2) and uliginosin (3) Hypericum species. Promastigotes amastigotes Leishmania amazonensis were incubated with compounds 1–3 at concentrations 1–100 µ m 48 h. The anti-promastigote effect was also tested in combinations. cytotoxicity macrophages human erythrocytes determined using...
In this study, a phytochemical and biological investigation on five South Brazilian Hypericum species ( caprifoliatum , carinatum connatum myrianthum polyanthemum ) was carried out. The phloroglucinol‐enriched fractions (PEF) of the flowering aerial parts were analyzed by high‐performance liquid chromatography for content uliginosin A 1 ), japonicin 2 B 3 hyperbrasilol 4 three benzopyrans, that is, 6‐isobutyryl‐5,7‐dimethoxy‐2,2‐dimethyl‐benzopyran (HP1) 5...
The phytochemical composition of Arnaldoa species is barely known. In this work, the occurrence caffeic acid ester derivatives and flavonoids in A. argentea, macbrideana weberbaueri was established by liquid chromatography associated to high-resolution mass spectrometry analyses comparison with data from isolated compounds. distribution chlorogenic acids genus herein described for first time. metabolite profile compared that Tithonia diversifolia, a known rich source sesquiterpene lactones....
Fungal resistance to different therapeutic drugs has become a growing challenge. This crucial health problem requires new effective drug alternatives. Herein, we report the study of Eucalyptus botryoides' resin used in folk medicine as antimicrobial. Thus, E. was extracted with aqueous-ethanol and fractionated using Sephadex chromatography, furnishing its major compounds. The crude extracts isolated compounds were evaluated for their vitro antimicrobial activity against bacteria yeasts....
This work describes the isolation of seven (1–7) secondary metabolites from Espeletia barclayana (Asteraceae, Espeletiinae) and their identification by spectroscopic (NMR) spectrometric (MS) techniques. Ten (8–17) additional compounds were identified based on retention times, high-resolution mass spectrometry data, comparison with reference substances or data literature. The systematic significance some – sesquiterpene lactone longipilin acetate, four caffeoylquinic acids two...