A5066947589- Glioma Diagnosis and Treatment
- Epilepsy research and treatment
- Brain Metastases and Treatment
- Pharmacological Effects and Toxicity Studies
- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Colorectal Cancer Surgical Treatments
- Prostate Cancer Treatment and Research
- Cancer Genomics and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Meningioma and schwannoma management
- Gastroesophageal reflux and treatments
- Lung Cancer Research Studies
- Prostate Cancer Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- MRI in cancer diagnosis
- Global Cancer Incidence and Screening
- Medical Imaging Techniques and Applications
- Colorectal and Anal Carcinomas
- Helicobacter pylori-related gastroenterology studies
- Cancer, Hypoxia, and Metabolism
- Histone Deacetylase Inhibitors Research
- Colorectal Cancer Screening and Detection
- Protein Degradation and Inhibitors
Medisch Centrum Haaglanden
2014-2024
Groene Hart Ziekenhuis
2016-2017
Leiden University Medical Center
2015
European Organisation for Research and Treatment of Cancer
2015
Erasmus University Rotterdam
2009-2015
Erasmus MC
2006-2015
GGD Haaglanden
2015
Amsterdam UMC Location Vrije Universiteit Amsterdam
2013-2015
Sorbonne Université
2013
Pitié-Salpêtrière Hospital
2013
A better understanding of transcriptional evolution IDH-wild-type glioblastoma may be crucial for treatment optimization. Here, we perform RNA sequencing (RNA-seq) (n = 322 test, n 245 validation) on paired primary-recurrent resections patients treated with the current standard care. Transcriptional subtypes form an interconnected continuum in a two-dimensional space. Recurrent tumors show preferential mesenchymal progression. Over time, hallmark genes are not significantly altered. Instead,...
Aims: To determine interobserver variation in grading of dysplasia Barrett's oesophagus (BO) between non‐expert general pathologists and expert gastrointestinal on the one hand other hand. Methods results: In this prospective multicentre study, graded biopsy specimens 920 patients with endoscopic BO, which were blindly reviewed by member a panel (panel experts) second case disagreement grade. Agreement two three was established as final diagnosis. Analysis performed κ statistics. Due to...
To examine the efficacy of valproic acid (VPA) given either with or without levetiracetam (LEV) on seizure control and survival in patients glioblastoma multiforme (GBM) treated chemoradiation.A retrospective analysis was performed 291 GBM. The efficacies VPA LEV alone as polytherapy were analyzed 181 (62%) seizures a minimum follow-up 6 months. Cox-regression 165 receiving chemoradiation temozolomide whom 108 this combination for at least 3 months.Monotherapy instituted 137/143 (95.8%)...
Patients with Barrett's esophagus (BE) have an increased risk of developing esophageal adenocarcinoma (EAC). As the absolute remains low, there is a need for predictors neoplastic progression to tailor more individualized surveillance programs. The aim this study was identify such high-grade dysplasia (HGD) and EAC in patients BE after 4 years develop prediction model based on these factors.We included 713 (≥ 2 cm) no (ND) or low-grade (LGD) multicenter, prospective cohort study. Data age,...
The efficacy of novel targeted therapies is often tested at the time tumor recurrence. However, for glioblastoma (GBM) patients, surgical resections recurrence are performed only in a minority patients; therefore, molecular data predominantly derived from initial tumor. Molecular patient selection into personalized medicine trials can therefore be used when specific genetic change retained recurrent In this study we determined whether EGFR amplification and expression most common mutation...
Precision medicine trials in glioblastoma (GBM) are often conducted at tumor recurrence. However, second surgeries for recurrent GBM not routinely performed, and therefore, molecular data trial inclusion predominantly derived from the primary sample. This study aims to establish whether targets change during progression and, if so, this affects precision design.We collected 186 pairs of primary-recurrent samples patients receiving chemoradiotherapy with temozolomide sequenced approximately...
It is difficult to predict the presence of histological risk factors for lymph node metastasis (LNM) before endoscopic treatment T1 colorectal cancer (CRC). Therefore, therapy propagated obtain adequate staging. We examined whether secondary surgery following resection high-risk CRC does not have a negative effect on patients' outcomes compared with primary surgery. Patients one or more LNM (high risk) and treated between 2000 2014 in 13 hospitals were identified Netherlands Cancer Registry....
The decision to perform secondary surgery after endoscopic resection of T1 colorectal cancer (CRC) depends on the risk lymph node metastasis and incomplete resection. We aimed examine incidence factors for CRC a macroscopic radical resection.Data from patients treated between 2000 2014 with complete were collected 13 hospitals. Incomplete was defined as local recurrence at polypectomy site during follow-up or malignant tissue in surgically resected specimen case performed. Multivariate...
Endoscopic mucosal resection (EMR) is currently the most used technique for of large distal colorectal polyps. However, in lesions EMR can often only be performed a piecemeal fashion resulting relatively low radical (R0)-resection rates and high recurrence rates. submucosal dissection (ESD) newer procedure that more difficult longer procedural time, but promising due to en-bloc very We aim evaluate (cost-)effectiveness ESD against on both short (i.e. 6 months) long-term 36 months)....
When glioma patients experience long-term seizure freedom the question arises whether antiepileptic drugs (AEDs) should be continued. As no prospective studies exist on recurrence in after AED withdrawal, we evaluated decision-making process to withdraw AEDs patients, and outcome withdrawal. Patients with a histologically confirmed low grade or anaplastic were included. Eligible free ≥ 1 year from date of last antitumor treatment, 2 years since when seizures occurred end treatment....
Patients with Barrett's esophagus are recommended to undergo regular surveillance upper gastrointestinal endoscopy, an invasive procedure that may cause anxiety, pain, and discomfort. We assessed what extent patients perceived this as burdensome.A total of 192 were asked fill out questionnaires at 1 week immediately before month afterwards. Four variables assessed: (i) pain discomfort experienced during endoscopy; (ii) symptoms; (iii) psychological burden, i. e., depression distress levels...
To assess the applicability of perfusion-weighted (PWI) magnetic resonance (MR) imaging in clinical practice, as well to evaluate changes PWI brain metastases before and after stereotactic radiotherapy (SRT), correlate these tumor status on conventional MR imaging. Serial images at baseline least 3 6 months SRT were retrospectively evaluated. Size relative cerebral blood volume (rCBV), assessed with subjective visual inspection contrast enhanced area, evaluated each time point. Tumor...
Abstract The European Randomized study of Screening for Prostate Cancer (ERSPC) has recently reported a 20% reduction in death from prostate cancer population‐based screening (core age group: 55–69 years age). effect may be diluted by noncompliance the arm and contamination PSA testing control arm. purpose is to analyze on incidence metastatic cancer, both with without adjustment contamination. We analyzed occurrence metastases 42,376 men aged 55–75 who were randomized Rotterdam section...
EGFR is among the genes most frequently altered in glioblastoma, with exons 2-7 deletions (EGFRvIII) being its common genomic mutations. There are conflicting reports about prognostic role and it remains unclear whether how differs signaling compared wildtype EGFR.To better understand oncogenic of EGFRvIII, we leveraged 4 large datasets into 1 glioblastoma transcriptome dataset (n = 741) alongside 81 whole-genome samples from 2 datasets.The EGFRvIII/EGFR expression ratios differ strongly...
Abstract Background Stereotactic radiosurgery (SRS) is a frequently chosen treatment for patients with brain metastases and the number of long-term survivors increasing. Brain necrosis (e.g. radionecrosis) most important side effect treatment. Retrospective studies show lower risk radionecrosis local tumor recurrence after fractionated stereotactic (fSRS, e.g. five fractions) compared in one or three fractions. This especially true large metastases. As such, 2022 ASTRO guideline radiotherapy...
Background and purpose Conventional magnetic resonance imaging ( MRI ) has limited value for differentiation of true tumor progression pseudoprogression in treated glioblastoma multiforme GBM ). Perfusion weighted PWI may be helpful the these two phenomena. Here interobserver variability routine radiological evaluation patients is assessed using , including . Methods Three experienced neuroradiologists evaluated MR scans 28 during temozolomide chemoradiotherapy at three time points:...
Summary Background Intestinal metaplasia (Barrett's oesophagus), but not cardiac‐type mucosa in columnar‐lined oesophagus, is regarded as premalignant. As intestinal and are endoscopically indiscernible, it difficult to take targeted samples from oesophagus with consequently a risk of having undetected metaplasia. Aim To investigate whether the markers CDX2, MUC2 villin can predict presence oesophagus. Methods Presence or was identified 122 biopsy sets 61 patients, collected at two...
A 45-year-old man with Crohn's disease diagnosed in 1988 who had undergone an ileocecal resection end-to-side anastomosis 1995 presented pain the right lower abdomen. colonoscopy was performed using Olympus colonoscope (Tokyo, Japan), during which a noninflamed fibrotic stricture of that could not be passed by endoscope found ([Fig. 1]). Because patient refused surgery, six balloon dilations were at 3-monthly intervals. Unfortunately these resulted limited improvement both degree stenosis...
Withdrawal of antiseizure medication treatment (ASM) can be considered after completion antitumour in glioma patients who no longer suffer from seizures. We compared the risk for recurrent seizures ASM withdrawal between with short-term, medium-term versus long-term seizure freedom treatment.In this retrospective observational study, primary outcome was time to seizure, starting date up 36 months follow-up. Cox proportional hazards models were used study effect factors on seizure....