A5057277954- Functional Brain Connectivity Studies
- EEG and Brain-Computer Interfaces
- Neural dynamics and brain function
- Epilepsy research and treatment
- Advanced MRI Techniques and Applications
- Neural and Behavioral Psychology Studies
- Photosynthetic Processes and Mechanisms
- Advanced Fluorescence Microscopy Techniques
- Advanced Electron Microscopy Techniques and Applications
- Glioma Diagnosis and Treatment
- Neuroscience and Neuropharmacology Research
- Advanced Neuroimaging Techniques and Applications
Newcastle University
2023-2024
University of Wisconsin–Madison
2021-2023
University of Amsterdam
2021
The relationship between conscious experience and brain activity has intrigued scientists philosophers for centuries. In the last decades, several theories have suggested different accounts these relationships. These developed in parallel, with little to no cross-talk among them. To advance research on consciousness, we established an adversarial collaboration proponents of two major field, Global Neuronal Workspace Integrated Information Theory. Together, devised preregistered experiments...
Summary Different theories explain how subjective experience arises from brain activity 1,2 . These have independently accrued evidence, yet, confirmation bias and dependence on design choices hamper progress in the field 3 Here, we present an open science adversarial collaboration which directly juxtaposes Integrated Information Theory (IIT) 4,5 Global Neuronal Workspace (GNWT) 6–10 , employing a theory-neutral consortium approach 11,12 We investigate neural correlates of content duration...
Objective correlates-behavioral, functional, and neural-provide essential tools for the scientific study of consciousness. But reliance on these correlates should not lead to 'fallacy misplaced objectivity': assumption that only objective properties can be accounted objectively through science. Instead, what needs explained scientifically is experience intrinsically-its subjective properties-not just we do with it extrinsically. And must explained; otherwise way feels would turn out magical...
Abstract Different theories explain how subjective experience arises from brain activity1,2. These have independently accrued evidence, yet, confirmation bias and dependence on design choices hamper progress in the field3. Here, we present an open science adversarial collaboration which directly juxtaposes Integrated Information Theory (IIT)4,5 Global Neuronal Workspace (GNWT)6-10, employing a theory-neutral consortium approach11,12. We investigate neural correlates of content duration...
Delineation of seizure onset regions using intracranial electroencephalography (icEEG) is vital in the surgical workup drug-resistant epilepsy cases. However, it unknown whether complete resection these necessary for freedom, or postsurgical recurrence can be attributed to incomplete removal regions. To address this gap, we retrospectively analyzed icEEG recordings from 63 subjects, identifying visually and algorithmically. We assessed region correlated with control. The majority subjects...
Accurate identification of abnormal electroencephalographic (EEG) activity is pivotal for diagnosing and treating epilepsy. Recent studies indicate that decomposing brain into periodic (oscillatory) aperiodic (trend across all frequencies) components can illuminate the drivers spectral changes.
Loss of consciousness is a hallmark many epileptic seizures and carries risks serious injury sudden death. While cortical sleep-like activities accompany loss during focal impaired awareness seizures, the mechanisms to bilateral tonic-clonic remain unclear. Quantifying differences in markers activation ictal recruitment between may also help us understand their different consequences for clinical outcomes optimize neuromodulation therapies. We quantified signs intracranial EEG activity 129...
We examined the ability of using Behnke-Fried recordings to identify multi-unit activity (MUA) changes during focal bilateral tonic-clonic (FBTC), impaired awareness (FIA) and aware (FA) seizures.
EEG slowing is reported in various neurological disorders including Alzheimer's, Parkinson's and Epilepsy. Here, we investigate alpha rhythm individuals with refractory temporal lobe epilepsy (TLE), compared to healthy controls, using scalp electroencephalography (EEG) magnetoencephalography (MEG). We retrospectively analysed data from 17,(46) controls 22,(24) TLE who underwent (MEG) recordings as part of presurgical evaluation. Resting-state, eyes-closed were source reconstructed the...
Background: Understanding healthy human brain function is crucial to identify and map pathological tissue within it. Whilst previous studies have mapped intracranial EEG (icEEG) from non-epileptogenic regions, these maps do not consider the effects of age sex. Further, most existing work on icEEG has often suffered a small sample size due this modality's invasive nature. Here, we substantially increase subject compared literature, create multi-centre, normative activity which additionally...
Importance: Many individuals with drug-resistant epilepsy continue to have seizures after resective surgery. Accurate identification of focal brain abnormalities is essential for successful neurosurgical intervention. Current clinical approaches identify structural surgical targeting in do not use diffusion-weighted MRI (dMRI), despite evidence that dMRI are present and may relate the epileptogenic zone. Objective: To investigate whether resection diffusion relates post-operative seizure...
Abstract EEG slowing is reported in various neurological disorders including Alzheimer’s, Parkinson’s and Epilepsy. Here, we investigate alpha rhythm individuals with refractory temporal lobe epilepsy compared healthy controls, using scalp magnetoencephalography. We retrospectively analysed data from 17 (46) controls 22 (24) who underwent magnetoencephalography recordings as part of presurgical evaluation. Resting-state, eyes-closed were source reconstructed the standardized low-resolution...
Aperiodic activity is a physiologically distinct component of the electrophysiological power spectrum. It suggested to reflect balance excitation and inhibition in brain, within selected frequency bands. However, impact recurrent seizures on aperiodic remains unknown, particularly patients with severe bilateral seizures. Here, we hypothesised greater abnormality epileptogenic zone, focal tonic clonic (FBTC) seizures, earlier age seizure onset. Pre-operative magnetoencephalography (MEG)...
Abstract Loss of consciousness (LOC) is a hallmark many epileptic seizures and carries risks serious injury sudden death. While cortical sleep-like activities accompany LOC during focal impaired awareness (FIA) seizures, the mechanisms to bilateral tonic-clonic (FBTC) remain unclear. Quantifying differences in markers activation ictal recruitment between FIA FBTC may also help understand their different consequences for clinical outcomes optimize neuromodulation therapies. We quantified...
Identifying abnormal electroencephalographic activity is crucial in diagnosis and treatment of epilepsy. Recent studies showed that decomposing brain into periodic (oscillatory) aperiodic (trend across all frequencies) components may illuminate drivers changes spectral activity. Using iEEG data from 234 subjects, we constructed a normative map compared this with separate cohort 63 patients refractory focal epilepsy being considered for neurosurgery. The was computed using three approaches:...
Delineation of seizure onset regions from EEG is important for effective surgical workup. However, it unknown if their complete resection required freedom, or in other words, post-surgical recurrence due to incomplete removal the regions. Retrospective analysis icEEG recordings 63 subjects (735 seizures) identified through visual inspection and algorithmic delineation. We analysed correlated this with control. Most had over half resected (70.7% 60.5% methods, respectively). In investigating...