A5061844949- Reproductive Biology and Fertility
- Mitochondrial Function and Pathology
- Metabolism and Genetic Disorders
- Prenatal Screening and Diagnostics
- ATP Synthase and ATPases Research
- Assisted Reproductive Technology and Twin Pregnancy
- Ovarian function and disorders
- Sperm and Testicular Function
- Renal and related cancers
- Pregnancy and Medication Impact
- Reproductive Health and Technologies
- Genetic Syndromes and Imprinting
- Reproductive System and Pregnancy
- Endometriosis Research and Treatment
- Epigenetics and DNA Methylation
- Pregnancy and preeclampsia studies
- Heavy Metal Exposure and Toxicity
- Circadian rhythm and melatonin
- Birth, Development, and Health
- Genetics, Aging, and Longevity in Model Organisms
- Pluripotent Stem Cells Research
- CRISPR and Genetic Engineering
- Reproductive Health and Contraception
- RNA modifications and cancer
- Demographic Trends and Gender Preferences
Anhui Medical University
2016-2025
First Affiliated Hospital of Anhui Medical University
2016-2025
Health and Family Planning Commission of Sichuan Province
2025
Anhui Provincial Hospital
2022-2024
Ministry of Education of the People's Republic of China
2020-2024
Shanghai Medical College of Fudan University
2020
Zhongshan Hospital
2020
State Key Laboratory of Medical Neurobiology
2020
Institut de Médecine de la Reproduction
2019
Oregon Health & Science University
2016-2019
Melatonin (MT) regulates reproductive performance as a potent antioxidant; however, its beneficial effects on oocyte development remain largely unknown, especially in human oocytes. The collected 193 immature oocytes from the controlled ovarian hyperstimulation (COH) cycle underwent vitro maturation (IVM) IVM medium contained 10 μmol/L MT (n = 105, M group) and no 88, NM group), followed by insemination embryo culture. results showed that high-quality blastocyst formation rate group (28.4%)...
Ovarian reserve (OR) and fertility are critical in women's healthcare. Clinical methods for encoding OR rely on the combination of tests, which cannot serve as a multi-functional platform with limited information from specific biofluids. Herein, metabolic fingerprinting follicular fluid (MFFF) follicles is performed, using particle-assisted laser desorption/ionization mass spectrometry (PALDI-MS) to encode fertility. PALDI-MS allows efficient MFFF, showing fast speed (≈30 s), high...
Endometriosis is a common gynecological disease that affects approximately 5 %∼10 % of reproductive-aged women. Zinc (Zn), selenium (Se), copper (Cu), cobalt (Co) and molybdenum (Mo) are essential trace elements very important for human health. However, studies on the relationship between mixtures risk endometriosis limited inconsistent. In particular, confirming association via different sample types limited. This study aimed to investigate associations Zn, Se, Cu, Co Mo concentrations in...
To assess the feasibility of first polar body transfer (PB1T) combined with preimplantation mitochondrial genetic testing for blocking transmission a pathogenic DNA 8993T>G mutation. A Chinese family affected Leigh syndrome which had attended Reproductive Medicine Centre First Affiliated Hospital Anhui Medical University in September 2021 was selected as study subject. Controlled ovarian hyperstimulation carried out proband after completing detection mutation load among pedigree members....
Inadequate water supply during droughts, leading to socio-economic drought, has become a global issue. In this context, the drought resistance and disaster mitigation capabilities of reservoirs play crucial role events. Taking downstream Yellow River Basin (DYRB) as study area, research analyzes evolution characteristics in region from 1956 2016 at different time scales (3 months, 6 9 12 months). The copula function is used calculate joint recurrence period area. addition, constructs...
What is the potential of applying non-invasive preimplantation genetic testing (niPGT) for chromosome abnormalities in blastocysts reported with a mosaic trophectoderm (TE) biopsy?niPGT cell-free DNA blastocyst culture medium exhibited good diagnostic performance putative blastocysts.Advances niPGT have demonstrated reliability as resource assessment, but information on embryos scarce because mosaicism may interfere niPGT. In addition, high incidence context PGT and viability raise questions...
Toxic and essential trace elements are reported to have impact on female fertility. However, studies the potential synergistic or antagonistic effects of metal mixtures IVF outcomes remain limited.To evaluate whether serum concentrations metals, individually as mixtures, associated with pregnancy in women undergoing IVF.In a prospective birth cohort study about from First Affiliated Hospital Anhui Medical University (n = 1184), we measured metals by ICP-MS according previously established...
The conversion of DNA 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) by TET enzymes represents a significant epigenetic modification, yet its role in early human embryos remains largely unknown. Here we showed that the embryo inherited amount 5hmCs from an oocyte, which unexpectedly underwent de novo hydroxymethylation during growth. Furthermore, generation 5hmC paternal genome after fertilization roughly followed maternal pattern, was linked methylation dynamics and regions...
Diminished ovarian reserve (DOR) is defined as decreased number or quality of follicles and oocytes in a woman at childbearing age. It estimated that up to 10% women the general population may suffer from DOR. This study aims comprehensively characterize microRNA (miRNA) Piwi-interacting RNA (piRNA) expression profiles cumulus cells DOR patients. Cumulus were collected 20 similar chronological age who received assisted reproductive technology treatment: 10 with normal (NOR). The small RNAs...
Summary To explore whether different polyvinylpyrrolidone (PVP) concentrations affect the results of intracytoplasmic sperm injection (ICSI), a prospective study was conducted for 194 couples undergoing 210 ICSI therapy cycles. These cycles were divided into three groups (10, 7 and 5% groups) using corresponding concentration PVP immobilization. The main outcome measures analyzed. Results indicated that, with decrease in concentrations, all increased. In particular, high-quality cleavage...