A5088308514- Chronic Obstructive Pulmonary Disease (COPD) Research
- Lung Cancer Treatments and Mutations
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Lung Cancer Diagnosis and Treatment
- Aortic Disease and Treatment Approaches
- Colorectal Cancer Treatments and Studies
- Respiratory Support and Mechanisms
- Pleural and Pulmonary Diseases
- Effects of Radiation Exposure
- Lung Cancer Research Studies
- Cancer Immunotherapy and Biomarkers
- Pneumothorax, Barotrauma, Emphysema
- Atomic and Subatomic Physics Research
- COVID-19 Clinical Research Studies
- Nutrition and Health in Aging
- Infectious Diseases and Tuberculosis
- Gastric Cancer Management and Outcomes
- Occupational and environmental lung diseases
- Infectious Disease Case Reports and Treatments
- Airway Management and Intubation Techniques
- Fungal Infections and Studies
- Intracranial Aneurysms: Treatment and Complications
- Inhalation and Respiratory Drug Delivery
- Dietary Effects on Health
- Antibiotics Pharmacokinetics and Efficacy
Shiga University of Medical Science
2016-2024
Amur State Medical Academy
2021
Shiga University of Medical Science Hospital
2019-2020
Kishiwada City Hospital
2013
Hikone Central Hospital
2011-2012
To evaluate the efficacy and safety of nafamostat combined with favipiravir for treatment COVID-19.We conducted a multicenter, randomized, single-blind, placebo-controlled, parallel assignment study in hospitalized patients mild-to-moderate COVID-19 pneumonia. Patients were randomly assigned to receive alone (n = 24) or 21). The outcomes included changes World Health Organization clinical progression scale score, time improvement body temperature, oxygen saturation (SpO2).There was no...
A 76-year-old man with a past history of acute exacerbation (AE) and idiopathic pulmonary fibrosis (IPF) was treated nintedanib because decline in his forced vital capacity over time. new small nodular lesion visible on computed tomography scan the chest before initiation nintedanib. Disease progression IPF change size were not detected during administration Nine months after starting nintedanib, patient diagnosed gangrenous appendicitis, treatment discontinued. The increased four cessation...
Abstract Lessons Learned Non-small-cell lung cancer (NSCLC) represents 85% of in elderly patients. In the present study performed 36 subjects with epidermal growth factor receptor (EGFR) T790M mutation-positive NSCLC, osimertinib 80 mg demonstrated statistically significant improvement objective response rate, which was comparable to those nonelderly population. Osimertinib appears be an effective and safe treatment option patients advanced NSCLC EGFR mutation; further research larger scale...
The risk factors for radiation pneumonitis (RP) in patients with chronic obstructive pulmonary disease (COPD) are unclear. Mean lung dose (MLD) and percentage of irradiated volume common predictors RP, but the most accurate dosimetric parameter has not been established. We hypothesized that total without emphysema would influence onset RP.We retrospectively evaluated 100 who received radiotherapy cancer. RP was graded according to Common Terminology Criteria Adverse Events (version 4.03)....
Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are used for treating EGFR-mutated lung cancer, and osimertinib is effective in cases that acquired T790M mutations after treatment with the first- second-generation EGFR-TKIs. However, no study has evaluated its safety efficacy older patients. This phase II trial (jRCTs071180002) mutation-positive Japanese patients who were ≥75 years old had experienced relapse or progression previous EGFR-TKI treatment. Our report...
Background Altered gut microbiota may contribute to COPD development or progression. Herein, we investigated the association of microorganisms with COPD, taking into account impact smoking status. Methods This cross-sectional observational study was a part Shiga Epidemiological Study Subclinical Atherosclerosis, population-based cohort Japanese men aged 46–76 years, conducted from 2010 2016. The microbiome, determined using 16S rRNA gene sequencing, compared among 99 never-smokers, 306...
Immune-mediated pneumonitis has a high mortality rate; however, information regarding the related risk factors remains limited. This study aimed to analyze for pneumonitis, including smoking and lung metastasis (LM), in patients with extrapulmonary primary tumors.Data of 110 treated immune checkpoint inhibitors (ICIs) (nivolumab/pembrolizumab) treating tumors at Shiga University Medical Science Hospital between January 2015 December 2019 were retrospectively collected. The association onset...
Immune checkpoint inhibitors (ICIs) can cause immune-related adverse events (irAEs), such as neurological toxicity. A 46-year-old man was diagnosed with squamous cell lung cancer. Lung cancer recurred 3 years after he experienced left segmental rejection. Therefore, received atezolizumab fourth-line chemotherapy. He fever, headache, and decreased consciousness 10 days the first dose of atezolizumab. Plain head computed tomography cerebrospinal fluid examination showed no significant...
Dacomitinib significantly improves progression-free survival and overall (OS) compared with gefitinib in patients non-small-cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR)-activating mutations. However, dacomitinib often causes skin toxicities, resulting treatment discontinuation. We aimed to evaluate a prophylactic strategy for toxicity induced by dacomitinib.We performed single-arm, prospective, open-label, multi-institutional phase II trial comprehensive...
Weight and muscle loss are predictors of poor outcomes in chronic obstructive pulmonary disease. However, to our knowledge, no study has investigated the longitudinal weight or its composition from functional morphological perspectives.This observational with a median follow-up period 5 years (range: 3.0-5.8 years) included patients COPD ever-smokers at risk COPD. Using chest computed tomography (CT) images, airway emphysematous lesions were assessed as square root wall area hypothetical an...
Mucormycosis is a rare complication in immunocompromised patients. Antemortem diagnosis of mucormycosis difficult and often incorrect. We report case pulmonary caused by Cunninghamella bertholletiae an elderly man with interstitial pneumonia. The was established bronchoalveolar lavage. A coexisting immune deficiency condition considered. Lung cancer suspected because elevated progastrin-releasing peptide level bilateral hilar mediastinal lymphadenopathy; it diagnosed after performing...
The constraint values of dose-volume histogram (DVH) parameters for radiation pneumonitis (RP) prediction have not been uniform in previous studies. We compared the differences between conventional DVH and with high attenuation volume (HAV) CT imaging both esophageal cancer lung patients to determine most suitable predicting RP onset. Seventy-seven 72 who underwent therapy cancer, respectively, were retrospectively assessed. was valued according Common Terminology Criteria Adverse Events....
A 72-year-old man with chronic obstructive pulmonary disease (COPD) was admitted for coronavirus 2019 (COVID-19). He discharged on day 30; however, he readmitted 6 days later due to a left lung organizing pneumonia secondary COVID-19. After methylprednisolone treatment, the patient 15. One year later, computed tomography showed shrinkage of emphysematous lesions, and both total capacity measured using fraction low attenuation volume decreased in compared that before Here, we report rare case...
Disease probability measure (DPM) is a useful voxel-wise imaging assessment of gas-trapping and emphysematous lesions in patients with chronic obstructive pulmonary disease (COPD). To elucidate the progression COPD, we performed cluster analysis using following DPM parameters: normal (DPMNormal), (DPMGasTrap), (DPMEmph). Our findings revealed characteristics each 3-year parameters.Inspiratory expiratory chest computed tomography (CT) images 131 COPD were examined, which 84 followed up for 3...
<b>BACKGROUND:</b> Many patients with idiopathic pulmonary fibrosis (IPF) have smoking history and emphysematous lesions. However, there are no reports using quantitative computed tomography (CT) analysis of both emphysema in IPF patients. We recently reported the method to quantify honeycombing area (HA) CT. hypothesized that extent might predict survival IPF. In this study, we measured HA history. <b>METHODS:</b> Chest CTs 61 were retrospectively evaluated. first then calculated as...
Intervention: Inhaled dry-powder beclomethasone 1200 mcg per day compared with placebo Primary Outcome: The primary endpoint is progression of disease severity defined by Á oxygen saturation drop < 94% and any one the following 3 treatment escalation steps: o initiation supplemental dexamethasone transfer to a higher-tier healthcare facility Sample Size: 190 arm Sampling Method: Participants randomized inhaled or placebo, in addition usual care, random sequence generator 1:1 ratio double...
An 8-year-old girl presented at the emergency department with coughing and wheezing. She had been playing a ballpoint pen in her mouth when parents called her, tip of disappeared this time point. No abnormality was noted region from to larynx, chest radiography results were unremarkable. The wheezing persisted; therefore, she admitted paediatrics …
A 72-year-old man with chronic obstructive pulmonary disease (COPD) was admitted for coronavirus 2019 (COVID-19). He discharged on day 30; however, he readmitted 8 days later because of organizing pneumonia in his left lung due to COVID-19. After methylprednisolone treatment, the patient 15. One year later, computed tomography showed shrinkage emphysema, and both total capacity measured using fraction low attenuation volume decreased compared that before Here, we report a rare case...
<b>Introduction and Objectives:</b> Disease Probability Measure (DPM) is a useful image assessment tool for gas-trapping emphysema using inspiratory expiratory computed tomography (CT) data chronic obstructive pulmonary disease (COPD). We hypothesized that the cluster analysis DPM parameters could help to understand relationship between pathological changes of lungs other in COPD. <b>Methods:</b> A total 131 COPD patients were enrolled. Forced oscillation technique (FOT), spirometry CT scans...