A5044624353- Acute Myocardial Infarction Research
- Cardiac Valve Diseases and Treatments
- Venous Thromboembolism Diagnosis and Management
- COVID-19 Clinical Research Studies
- Aortic Disease and Treatment Approaches
- Heart Failure Treatment and Management
- Atrial Fibrillation Management and Outcomes
- Cardiac Imaging and Diagnostics
- Cardiac electrophysiology and arrhythmias
- Long-Term Effects of COVID-19
- Blood properties and coagulation
- Blood Pressure and Hypertension Studies
- Sepsis Diagnosis and Treatment
- Aortic aneurysm repair treatments
- Reproductive tract infections research
- COVID-19 and healthcare impacts
- Cardiac pacing and defibrillation studies
- Congenital Heart Disease Studies
- Heparin-Induced Thrombocytopenia and Thrombosis
- Gastrointestinal motility and disorders
- Antiplatelet Therapy and Cardiovascular Diseases
- Semiconductor materials and devices
- Vasculitis and related conditions
- Clinical Laboratory Practices and Quality Control
- Cardiovascular Function and Risk Factors
Wuhan Asia Heart Hospital
2015-2025
Wuhan University
2015-2025
Wuhan General Hospital of Guangzhou
2020-2024
Wuhan University of Science and Technology
2020-2024
Zhejiang Normal University
2021
Zhongnan Hospital of Wuhan University
2013-2016
Sun Yat-sen University
2006-2009
University of Hong Kong
2009
George Mason University
2009
Queen Mary Hospital
2009
Background and Purpose— The prevalence of constipation after stroke varies from 30% to 60%. incidence new-onset during the early stage remains uncertain. present study was designed investigate constipation, its risk factors, impact on outcome in patients with their first at acute stage. Methods— This is a prospective cohort 154 admitted stroke. New-onset 4 weeks recorded, using Rome II criteria for constipation. Demographics, characteristics stroke, laboratory parameters, use medications...
Objective We explored the desaturase activities and correlation of fatty acid desaturases (FADS) gene single nucleotide polymorphisms (SNPs) with plasma in coronary artery disease (CAD) patients a Chinese Han population. Methods Plasma acids were measured by gas chromatography CAD (n = 505) control group 510). Five SNPs FADS genotyped high-resolution melting (HRM) methods. Results After adjustment, D6D activity, assessed as arachidonic (AA, C20:4n-6)/linoleic (LA, C18:2n-6), was higher...
Cardiac troponin (cTn) is the key biomarker for diagnosis of acute coronary syndrome (ACS). We performed a complete assessment high-sensitivity cardiac I (hs-cTnI) (CLIA) assay on analytical performance and clinical diagnostic performance, which was compared with Abbott ARCHITECT hs-cTnI assay.
Abstract Background Current studies suggest that cardiac troponin (cTn) forms in the circulation may vary different clinical scenarios. Our aim was to design a combination of cTn assays specific main and evaluate their analytical performance. Methods We developed immunoassays for measuring (1) long-cTnT cTnI-cTnT-TnC (ITC) ternary complex, with cTnT long form without cleavage at C-terminal amino acids residue 189–223, designated “long-cTnT ITC complex assay;” (2) both plus short-cTnT...
Severe/critical patients with coronavirus disease 2019 (COVID-19) have become the central issue in current global pandemic due to their high mortality rate. However, relationship between antibody response and clinical outcomes has not been well described this group. We conducted a single-center, retrospective, cohort study investigate serum immunoglobulin G (IgG) IgM severe/critical COVID-19. Seventy-nine COVID-19 admitted Wuhan Asia General Hospital Wuhan, China during January 22, 2020...
Abstract Background Increased cardiac troponin (cTn) concentrations occur in acute myocardial injury and chronic diseases. Characterization of cTn composition the circulation may assist differentiating etiologies injury. Our goal was to study kinetics patients following type 1 infraction (T1MI), procedures, heart diseases establish relationship between clinical diagnosis. Methods Plasma samples were collected from 201 with T1MI, 78 undergoing surgeries, 218 cardiomyopathy or failure. Major...
Abstract Objectives The N-terminal fragment of pro-B-type natriuretic peptide (NT-proBNP) is a widely used heart failure (HF) biomarker. Commercial NT-proBNP immunoassays detect only subfraction endogenous NT-proBNP, as the antibodies target region that could be glycosylated at Ser44. diagnostic utility measuring total remains unclear. Methods was measured in 183 HF and 200 non-HF patients diagnosed by two independent cardiologists blinded to results. Plasma samples either non-treated or...
The goal of this study was to evaluate plasma D-dimer as a diagnostic marker for exclusion suspected aortic dissection (AD).Two-hundred and sixty AD patients were enrolled, including acute AD, n=107; chronic n=17; myocardial infarction (AMI), n=70; pulmonary embolism (PE), n=18; non-ST elevation (NSTEMI), n=28; unstable angina (UA), n=20. All had testing performed (Roche Diagnostics GmbH) immediately following admission.The concentrations in both the group [median: 3.47; 95% confidence...
Aim: To compare the accuracy of nine selected algorithms for predicting warfarin dose with 586 Han Chinese patients. Materials & methods: Genotyping VKORC1 1639G>A, CYP2C9*2 and CYP2C9*3 variants was performed. Both mean absolute error ideal estimation value were used comparison. Results: The top three performers from East Asians. Caucasians generally performed better in medium-dose subgroup (>3 <7 mg/day), while Asians low-dose (≤3 mg/day). None well high-dose (≥7 Conclusion: Algorithms...
D‐dimer test, one of the most common tests for coagulation, plays an important role in management patients with thrombosis, and its demand has risen sharply during current global COVID‐19 epidemic. However, some main limitations, including inconsistent reporting units, various thresholds different assays, lack standardization, poor harmonization,1.Thachil J. Lippi G. Favaloro E.J. testing: laboratory aspects issues.Methods Mol Biol. 2017; 1646: 91-104Crossref PubMed Scopus (36) Google...
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Mechanical heart valve replacement (MHVR) entails lifetime oral anticoagulation to eliminate thrombosis. However, adverse events may still occur despite proper therapy. In this study, we investigated whether D-dimer can predict the clinical in post-MHVR patients during therapy.This was a single-center, prospective study. all, 772 who underwent MHVR Wuhan Asia Heart Hospital from January 2013 May 2014 were screened. Patients assigned abnormal group and normal according levels measured 3...