A5053260345- Viral Infections and Vectors
- Fire effects on ecosystems
- Mosquito-borne diseases and control
- Celiac Disease Research and Management
- Influenza Virus Research Studies
- Viral Infections and Outbreaks Research
- Microscopic Colitis
- Galectins and Cancer Biology
- Respiratory viral infections research
- Neonatal Respiratory Health Research
- Viral Infections and Immunology Research
- Liver Diseases and Immunity
- Vector-Borne Animal Diseases
- Animal Disease Management and Epidemiology
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- COVID-19 Impact on Reproduction
- Liver Disease Diagnosis and Treatment
- Gastrointestinal disorders and treatments
- Plant Virus Research Studies
- RNA and protein synthesis mechanisms
- T-cell and B-cell Immunology
- Bat Biology and Ecology Studies
- Reproductive System and Pregnancy
- Yersinia bacterium, plague, ectoparasites research
Administración Nacional de Laboratorios e Institutos de Salud
2014-2024
Centro Científico Tecnológico - San Juan
2023
Consejo Nacional de Investigaciones Científicas y Técnicas
2020-2022
Instituto Biológico
2022
National Center for Emerging and Zoonotic Infectious Diseases
2022
Centers for Disease Control and Prevention
2022
National University of General San Martín
2022
United States Army Medical Research Institute of Infectious Diseases
2020
University of Nebraska at Omaha
2020
Bariloche Atomic Centre
2020
From November 2018 through February 2019, person-to-person transmission of Andes virus (ANDV) hantavirus pulmonary syndrome occurred in Chubut Province, Argentina, and resulted 34 confirmed infections 11 deaths. Understanding the genomic, epidemiologic, clinical characteristics ANDV is crucial to designing effective interventions.Clinical epidemiologic information was obtained by means patient report from public health centers. Serologic testing, contact-tracing, next-generation sequencing...
The respiratory epithelium is a physical and functional barrier actively involved in the clearance of environmental agents. alveolar compartment lined with membranous pneumocytes, known as type I epithelial cells (AEC I), granular II II). AEC are responsible for reparation upon injury ion transport very active immunologically, contributing to lung defense by secreting antimicrobial factors. also secrete broad variety factors, such cytokines chemokines, activation differentiation immune able...
Abstract Hantavirus pulmonary syndrome (HPS) is an endemic disease in Argentina, one of the most affected countries Americas. Andes virus (ANDV) main Orthohantavirus species causing HPS Argentina. In this study, geographical distribution, clinical presentation, and epidemiological features from all regions Argentina were analyzed. We focused on data 533 cases confirmed during period 2009 to 2017 by National Reference Laboratory for Hantavirus. A case‐fatality rate 21.4% was registered,...
P athogenic hantaviruses are members of the fam- ily Hantaviridae and genus Orthohantavirus.These viruses responsible for hantavirus pulmonary syndrome (HPS) in Americas.In Argentina, HPS was first described 1995 during an outbreak Andean region Patagonia, leading to characterization Andes virus (ANDV) (1).Since then, >1,200 cases have been confirmed Argentina (2,3).Hantaviruses enveloped, single-stranded, RNA with tripartite negative sense genomes.The small (S, 1.8-2.1 kb) segment encodes a...
Orthohantaviruses are emerging rodent-borne pathogens that cause Hantavirus Pulmonary Syndrome in humans. They have a wide range of rodent reservoir hosts and transmitted to humans through aerosolized viral particles generated by the excretions infected individuals. Since first description HPS Argentina, new hantaviruses been reported throughout country, most which pathogenic We present here case with Alto Paraguay virus Argentina. Until now, was considered non-pathogenic orthohantavirus...
To investigate infiltrating cells in the liver of children with type 1 autoimmune hepatitis (AH-1).
The hallmarks of HPS are increase vascular permeability and endothelial dysfunction. Although an exacerbated immune response is thought to be implicated in pathogenesis, clear evidence still elusive. As orthohantaviruses not cytopathic CD8+ T cells believed the central players involved pathogenesis.Serum blood samples from Argentinean patients were collected 2014 2019. Routine white cell analyses, quantification characterization T-cell phenotypic profile, viral load, neutralizing antibody...
Abstract Hantavirus Pulmonary Syndrome (HPS), characterized by its high fatality rate, poses a significant public health concern in the Americas. Phylogenetic relationships of orthohantaviruses country were inferred from partial genomic sequences. The objectives this work to report new complete viral genomes known variants associated with HPS cases Central-East region Argentina, assess diversity, phylogenetic relationships, and elucidate geographic patterns distribution each variant. To...
Hantavirus Pulmonary Syndrome (HPS), characterized by its high fatality rate, poses a significant public health concern in Argentina due to the increasing evidence of person-to-person transmission Andes virus. Several orthohantaviruses were described country, but their phylogenetic relationships inferred from partial genomic sequences. The objectives this work assess viral diversity most prevalent associated with HPS cases Central-East (CE) region Argentina, elucidate geographic patterns...
We performed whole-genome sequencing with bait enrichment techniques to analyze Andes virus (ANDV), a cause of human hantavirus pulmonary syndrome. used cryopreserved lung tissues from naturally infected long-tailed colilargo, including early, intermediate, and late cell culture, passages an ANDV isolate that animal, golden hamsters experimentally exposed isolate. The resulting complete genome sequences were subjected detailed comparative genomic analysis against American orthohantaviruses....
In the present study, we addressed question of whether Toll-like receptor 2 (TLR2)-mediated innate immunity can contribute to development acquired immune responses. We immunized TLR2(-/-) and wild-type (WT) mice three times subcutaneously with mycobacterial antigen (Ag19kDa) (a TLR2 ligand) or Ag85A (not a ligand). One week after last immunization, sera spleens were collected. To evaluate cellular responses, measured gamma interferon (IFN-γ) in vitro restimulation spleen cells alone...
We describe a patient in Argentina with severe acute respiratory syndrome coronavirus 2 infection and hantavirus pulmonary (HPS). Although both disease HPS can be fatal when not diagnosed treated promptly, is much more lethal. This case report may contribute to improved detection of co-infections HPS-endemic regions.
Interleukin (IL)-15 and CD30 may be associated with the ongoing intestinal immunologic activation in celiac disease (CD). We studied duodenal biopsies blood samples of patients active CD (Cel) controls order to determine regulatory role proposed for CD30+ T cells this Th1-driven potential influences IL-15 on expression. detected that a T-cell subpopulation persists longer Cel after 5 day incubation anti-CD3 antibody than (p = 0.0063). upregulation by blasts was greater 0.0062). At mucosal...
SUMMARY The activity and circulation of influenza viruses in Argentina was studied during 2012 as part the Argentinean Surveillance for Influenza other Respiratory Viruses, context Global Surveillance. antigenicity molecular characteristics haemagglutinins (HA) circulating A B were analysed to assess emergence virus variants. Susceptibility oseltamivir zanamivir evaluated by enzymatic assay results backed-up sequencing neuraminidase (NA) genes. During season, detected from weeks 24 51. HA...
This study was conducted as part of the Argentinean Influenza and other Respiratory Viruses Surveillance Network, in context Global carried out by World Health Organization (WHO). The objective to activity antigenic genomic characteristics circulating viruses for three consecutive seasons (2010, 2011 2012) order investigate emergence influenza viral variants. During period, virus circulation detected from January December. A B, all current subtypes human viruses, were present each year....
Although vaccines are the best means of protection against influenza, neuraminidase inhibitors currently main antiviral treatment available to control severe influenza cases. One most frequent substitutions in (NA) protein A(H3N2) viruses during or soon after oseltamivir administration is E119V mutation. We describe emergence a mixed viral population with E119E/V mutation NA sequence post-treatment sample collected from an immunocompromised patient Argentina. This substitution was identified...