A5065141532- Reconstructive Surgery and Microvascular Techniques
- Patient-Provider Communication in Healthcare
- COVID-19 Clinical Research Studies
- Medical Malpractice and Liability Issues
- SARS-CoV-2 and COVID-19 Research
- Social Media in Health Education
- Child and Adolescent Health
- Clinical Reasoning and Diagnostic Skills
- Breast Implant and Reconstruction
- Body Contouring and Surgery
- Wound Healing and Treatments
- Orthopedic Surgery and Rehabilitation
- Craniofacial Disorders and Treatments
- Medical Imaging and Analysis
- Health Literacy and Information Accessibility
- Facial Nerve Paralysis Treatment and Research
- Mobile Health and mHealth Applications
- Peptidase Inhibition and Analysis
- Innovative Teaching Methods
- Innovations in Medical Education
- Patient Safety and Medication Errors
- SARS-CoV-2 detection and testing
- Reconstructive Facial Surgery Techniques
- Cleft Lip and Palate Research
- Food Security and Health in Diverse Populations
McMaster University
2025
Emory University
2022-2025
Seattle Children's Hospital
2022-2024
University of Toronto
2015-2023
University of Chicago
2023
University Health Network
2019-2022
Hospital for Sick Children
2019-2022
Sunnybrook Health Science Centre
2018-2022
Health Sciences Centre
2018-2022
University of Washington
2022
Type I interferons (IFN-I) are critical mediators of innate control viral infections but also drive the recruitment inflammatory cells to sites infection, a key feature severe coronavirus disease 2019. Here, IFN-I signaling was modulated in rhesus macaques (RMs) before and during acute SARS-CoV-2 (severe respiratory syndrome 2) infection using mutated IFN-α2 (IFN-modulator; IFNmod), which has previously been shown reduce binding endogenous IFN-I. IFNmod treatment uninfected RMs observed...
The continued evolution of SARS-CoV-2 variants capable subverting vaccine and infection-induced immunity suggests the advantage a broadly protective against betacoronaviruses (β-CoVs). Recent studies have isolated monoclonal antibodies (mAbs) from recovered-vaccinated donors neutralizing many other β-CoVs. Many these mAbs target conserved S2 stem region spike protein, rather than receptor binding domain contained within S1 primarily targeted by current vaccines. One S2-directed mAbs, CC40.8,...
<h3>Background:</h3> The choice of surgical approach for total hip arthroplasty (THA) remains a contentious issue with regards to clinical outcome optimization and restoring patient function. purpose this study was determine the impact THA on quantitative gait analysis. <h3>Methods:</h3> Patients undergoing primary osteoarthritis were assigned 1 3 approaches: anterior, posterior lateral. Standardized implants used at time surgery. Three-dimensional analysis performed preoperatively 6 12...
Background: Scapholunate advanced collapse (SLAC) is the most common pattern of wrist arthritis. Sparse data exist regarding SLAC This study aimed to document epidemiology in terms patients’ sociodemographics and possible association with trauma. Methods: Sixty-one patients severe were included. Baseline sociodemographic characteristics reviewed. To evaluate relationship injury, this group cases was compared a control 61 first carpometacarpal osteoarthritis (CMC OA). The following collected...
Abstract Type-I interferons (IFN-I) are critical mediators of innate control viral infections, but also drive recruitment inflammatory cells to sites infection, a key feature severe COVID-19. Here, and for the first time, IFN-I signaling was modulated in rhesus macaques (RMs) prior during acute SARS-CoV-2 infection using mutated IFNα2 (IFN-modulator; IFNmod), which has previously been shown reduce binding endogenous IFN-I. In SARS-CoV-2-infected RMs, IFNmod reduced both antiviral ISGs....
Gigantomastia remains a rare clinical diagnosis with significant physical and psychological impacts on patients. We present the case of 40-year-old woman idiopathic breast enlargement. Further histological analysis tissue revealed pseudoangiomatous stromal hyperplasia. This is first reported diffuse enlargement resulting from
Patient safety events are underreported by physicians. Baseline data demonstrated that physicians submitted 3% of event reports at Our Lady the Lake Children's Hospital. aim was to increase proportion filed residents and faculty 6% all within a 9-month period.We used Model for Improvement serial Plan, Do, Study, Act cycles test interventions we hypothesized would improve physician recognition reporting patient events. We tracked percentage Hospital entered or over time as primary outcome...
Background: Möbius syndrome is a complex congenital disorder of unclear cause involving multiple cranial nerves and typically presenting with bilateral facial abducens palsies. At The Hospital for Sick Children, Toronto, Ontario, Canada, microneurovascular transfer free-muscle transplant the procedure choice midfacial animation. primary aim this study was to investigate surgical outcomes in terms complications, secondary revisions, smile excursion gains. Methods: A retrospective 29-year...
Abstract Background Convergent evidence indicates that deficits in the endosomal recycling pathway underlies pathogenesis of Alzheimer’s disease (AD). SORL1 encodes retromer‐associated receptor SORLA plays an essential role AD‐associated cargos such as amyloid precursor protein and glutamatergic AMPA receptor. Importantly, loss function pathogenic variants are associated with AD. Moreover, both retromer levels reduced most vulnerable regions AD brains. Thus, restoration via viral...
Background: Microvascular breast reconstruction is a complex procedure that can be associated with high complication rates. Although number of individual predictors perioperative complications have been identified, few studies explored interaction between risk factors. Understanding the synergistic effects multiple factors central to accurate and personalized preoperative prediction. Methods: The authors conducted retrospective cohort study patients who underwent microvascular at their...
Abstract Background Immediate breast reconstruction has many advantages but is associated with higher complication rates than delayed reconstruction. Complications can delay the delivery of adjuvant cancer treatments. This study aimed to develop and validate a risk stratification model for prediction perioperative complications in immediate microvascular Methods The association between patient treatment variables was evaluated retrospective cohort 351 women undergoing using free deep...
Anabolic-androgenic steroids (AAS) are widely implicated in gynecomastia development. Surgery is the definitive treatment for cases persisting after cessation of AAS use. Currently, relevance use to surgical approach has not been well explored. This study aims compare patient characteristics, outcomes, and management correction users versus nonusers.A retrospective cohort was performed with patients who underwent bilateral reduction surgery between January 2005 August 2015 by a single...
Background: Health literacy represents the degree to which patients can understand and act on health information. The relevance of care delivery, outcomes, overall surgical is unambiguous. This study aimed (1) determine prevalence limited in diagnosed with Dupuytren’s contracture (2) identify independent predictors literacy. Methods: cross-sectional included disease self-reported English fluency. Newest Vital Sign, a rapid, validated, reliable screening tool, was selected measure An...
Active engagement in the learning process is important to enhance learners' knowledge acquisition and retention development of their thinking skills. This study evaluated whether a 1-hour faculty workshop increased use active teaching strategies enhanced residents' thinking.Faculty pediatrics residency participated (intervention) approximately 1 month before scheduled lecture. Participants' responses preworkshop/postworkshop questionnaire targeted self-efficacy (confidence) for facilitating...
<h3>Summary</h3> Decisional conflict represents a state of uncertainty regarding an action one must take. It is concept inherent to shared decision-making and can help promote high-quality patient-centred decisions in surgical care, leading better outcomes. Specific elements may cause more or decisional for patients: lack knowledge about risks benefits, poorly defined personal values the importance those perception support, unpredictable outcomes, impression that inadequate decision has been...
Background: The Accreditation Council for Graduate Medical Education (ACGME) requires evaluation of residents' communication skills. These evaluations should involve assessments from a variety persons with different perspectives and opportunities to observe resident behavior. Our objectives this study were determine if parents, nurses, physicians significantly differed in their ratings skills; ascertain the degree association between these ACGME milestone data; elicit feedback residents...