A5007744662- Cerebrospinal fluid and hydrocephalus
- Fetal and Pediatric Neurological Disorders
- Glaucoma and retinal disorders
- Corneal surgery and disorders
- Biomedical and Engineering Education
- Engineering Education and Curriculum Development
- Cerebral Venous Sinus Thrombosis
- Engineering Education and Pedagogy
- Ocular and Laser Science Research
- Cardiovascular Health and Disease Prevention
- Experimental Learning in Engineering
- Ophthalmology and Visual Impairment Studies
- Coronary Interventions and Diagnostics
- Laser Applications in Dentistry and Medicine
- Retinal and Optic Conditions
- Traumatic Brain Injury and Neurovascular Disturbances
- Spinal Dysraphism and Malformations
- Design Education and Practice
- Psychological and Educational Research Studies
- Barrier Structure and Function Studies
- Spatial Cognition and Navigation
- Neonatal and fetal brain pathology
- Learning Styles and Cognitive Differences
- Craniofacial Disorders and Treatments
- Additive Manufacturing and 3D Printing Technologies
The Ohio State University
2008-2024
Pennsylvania State University
2024
New Mexico Institute of Mining and Technology
2024
Hong Kong Sanatorium and Hospital
2005
Ohio Lions Eye Research Foundation
2005
Bausch & Lomb (France)
2005
Association for Research in Vision and Ophthalmology
2005
A better understanding of how hemodynamic factors affect the integrity and function vascular endothelium is necessary to appreciate more fully atherosclerosis initiated promoted. novel technique presented assess relation between fluid dynamic variables permeability macromolecules. Fully anesthetized, domestic swine were intravenously injected with albumin marker Evans blue dye, which was allowed circulate for 90 min. After animals euthanized, silicone casts made abdominal aorta its iliac...
Author(s): Tezel, Gulgun; Fourth ARVO/Pfizer Ophthalmics Research Institute Conference Working Group
Abnormal cerebrospinal fluid (CSF) flow is suspected to be a contributor the pathogenesis of neurodegenerative diseases such as Alzheimer's through accumulation toxic metabolites, and malfunction intracranial pressure regulation, possibly disruption neuroendocrine communication. For understanding transport processes involved in either, knowledge vivo CSF dynamics important. We present three-dimensional, transient, subject-specific computational analysis human cranial subarachnoid space (SAS)...
To describe and validate an in vitro model of the arachnoid granulation (AG) outflow pathway for cerebrospinal fluid (CSF), by using human AG cells grown on a filter membrane support perfused modified Ussing chamber at pressures analogous to normal intracranial pressures.Human were grown, characterized, seeded onto membranes, physiologic (basal apical, B-->A) or nonphysiologic (apical basal, A-->B) directions. Cells fixed under pressure after perfusion prepared electron microscopy (EM).The...
In Brief Purpose: To evaluate the response of posterior cornea after uneventful laser in situ keratomileusis (LASIK) with scanning-slit videokeratography using change elevation as a measure biomechanical remodeling. Setting: Hong Kong Sanatorium and Hospital, Kong, China. Methods: Three schematic models possible corneal mechanisms to refractive surgery were proposed: model A, isolated central bulging; B, forward shift over large region surface; C, backward peripheral movement into anterior...
We describe aggressive immunosuppressive treatment of an adolescent with Susac's syndrome (SS), a disease the microvasculature in brain, retina, and inner ear. Because immunopathogenesis SS appears to have much common that juvenile dermatomyositis (JDM), patient was treated approach has been effective for severe JDM. The patient's outcome provides evidence importance prompt, aggressive, sustained encephalopathic SS.
The arachnoid granulations (AGs) are herniations of the membrane into dural venous sinuses on surface brain. Previous morphological studies AGs have been limited in scope and only one has mentioned area measurements. purpose this study was to investigate topographic distribution superior cerebral cortex. En face images were taken 35 formalin-fixed human brains. manually identified using Adobe Photoshop, with a pixel location containing an AG defined as 'positive'. A set 25 standard fiducial...
Abstract The traditional engineering design process taught in universities across the country focuses on several common steps. Often these experiences place little emphasis creating value by defining a market opportunity or communicating overall economic and social impact. In collaboration with KEEN, network of thousands faculty working to unleash undergraduate engineers so that they can create personal, economic, societal through entrepreneurial mindset, large mid-western university is...
Abstract In this study, our team developed a virtual reality (VR) integrated curriculum for freshmen engineering visuospatial thinking course. Visuospatial skills, especially understanding how 2D image represents 3D object, are known to be an important part of student success in engineering. To ensure minimum level skills later courses, the Ohio State University offers course on incoming freshmen; it is required students that score below 18/30 Purdue Spatial Visualization Test: Rotations...
The brain's arachnoid membrane with granulations is an important biological barrier whose responsibilities include the transmission of cerebrospinal fluid (CSF) and regulation pressure. Membrane disturbance may cause changes that are difficult to replicate animal models, suggesting need for a model using human study conditions such as Alzheimer disease, hydrocephalus, pseudotumor cerebri. authors detail development validation ex vivo CSF outflow across (AGs) approximation in conditions.Human...
Abstract Background The arachnoid granulations (AGs) are projections of the membrane into dural venous sinuses. They function, along with extracranial lymphatics, to circulate cerebrospinal fluid (CSF) systemic circulation. Disruption normal CSF dynamics may result in increased intracranial pressures causing many problems including headaches and visual loss, as idiopathic hypertension hydrocephalus. To study role AGs egress, we have grown cells from human AG tissue vitro characterized their...
The arachnoid membrane (AM) and granulations (AGs) are important in cerebrospinal fluid (CSF) homeostasis, regulating intracranial pressure health disease. We offer a functional perspective of the human AM's transport mechanism to clarify role AM movement CSF metabolites. Using cultures AG cells specialized perfusion system, we have shown that this vitro model mimics vivo characteristics unidirectional present first report serum-free permeability values (92.5 µl min −1 mm Hg cm −2 ), which...
Purpose: To examine the effect of all-trans retinoic acid (ATRA) treatment on connexin 43 (Cx43) expression, gap junction intercellular communication (GJIC), and cellular differentiation in primary canine lens epithelial cells (LEC).
To culture physiologically functional primary arachnoidal cells on a suitable polymer substrate for an in-vitro model of the cerebrospinal fluid outflow pathway.Primary cultures were prepared within 24 hours post-mortem from brain tissue obtained human cadavers at autopsy. Arachnoidal characterized using immunocytochemistry and seeded onto needle punched non-woven poly(ethylene terephthalate)(PET) scaffolds. Metabolic rate, cell growth rate in log phase, morphologic assessment,...
Abstract Assessment of Inverted Classroom Success Based on Felder’s Index Learning StylesInverting the classroom is a pedagogical practice that has recently gained significant popularity. Withthe increase in its use, it essential to understand impacts and students’ experiencesin this type classroom. This structure was implemented first-year engineering courseat large Midwestern university accomplish two major goals: (1) provide an inclusive learningenvironment order accommodate learning...
Objective: To determine the effect of low-fluence diode laser irradiation upon fluid perfusion characteristics cultured human trabecular meshwork cell monolayers when placed in a specially designed testing apparatus and subjected to flow driven by hydrostatic pressure gradient. Methods: Two experimental series were conducted. In first series, six experiments conducted using grown on filter supports. Upon reaching steady state condition at approximately 5.0 mmHg, irradiated fluencies ranging...
Abstract Impact of Optional Supplemental Course to Enhance Spatial Visualization Skills in First-Year Engineering StudentsThe impact spatial visualization skills on retention and performance undergraduateengineering schools has been studied extensively. The National Science Foundation funded afive-year program called “Engaging Students Engineering” or ENGAGE. One strategy inENGAGE increase GPA freshman engineering students is improvestudents’ skills. With this goal mind, we have developed an...
Abstract The traditional engineering design process taught in universities across the country focuses on several common steps, although often placing little emphasis creating value. In collaboration with KEEN, a network of thousands faculty working to unleash undergraduate engineers so that they can create personal, economic, and societal value through entrepreneurial mindset, large mid-western university is adding multiple minded learning (EML) elements an existing first-year course. This...
Abstract Introduction In collaboration with KEEN, a network of thousands engineering faculty working to unleash undergraduate engineers so that they can create personal, economic, and societal value through the entrepreneurial mindset, large mid-western university added multiple minded learning (EML) elements an existing first-year course. This paper represents assessment findings from spring 2019 implementation new curriculum. Methods We used mixed methods quasi-experimental investigation...
Abstract This paper demonstrates the efficacy of 3D printing and laser cutting for customization components in an autonomous robotic design project first-year undergraduate engineering students. Interdisciplinary four-person student teams are challenged to design, build, program a completely robot capable performing series tasks which may include pushing buttons, flipping switches, distinguishing colored LED lights, lifting, transporting depositing objects. Additionally, robots must fit...
Abstract The efforts to incorporate an Entrepreneurial Mindset (EM) in engineering have grown significantly recent years. purpose of this work-in-progress research is determine what tools and methods are currently used assess EM, gaps exist the current practice. To practices we performed a comprehensive literature review, assessment review cards on Engineering Unleashed, series faculty interviews. tools, reviewed results from each data sets conducted additional industry Our team has now more...
Background Elevated levels of retinoic acid (RA) may cause dynamic vitamin A metabolic and genetic transcriptional changes that will lead to decreased cellular viability, proliferation, remodeling, adhesion a resultant decrease in permeability, which contributes elevated CSFP. RA subsequent formation retinyl esters, act as surfactants toxic response the arachnoid membrane leading