The detection of dyskalemias-hypokalemia and hyperkalemia-currently depends on laboratory tests. Since cardiac tissue is very sensitive to dyskalemia, electrocardiography (ECG) may be able uncover clinically important dyskalemias before results.Our study aimed develop a deep-learning model, ECG12Net, detect based ECG presentations evaluate the logic performance this model.Spanning from May 2011 December 2016, 66,321 records with corresponding serum potassium (K+) concentrations were obtained...

Background The reverse shock index multiplied by simplified motor score (rSI-sMS) is a novel and rapid measure for assessing injury severity in patients with trauma prehospital settings; however, its discriminant ability requires further validation.

Objectives To compare the effects of guided home‐based tai chi chuan ( TCC ) and lower extremity training LET levels self‐practice on falls functional outcomes in older fallers. Design Randomized controlled trial. Setting Taipei, Taiwan. Participants Individuals aged 60 who had fall‐related emergency department visits at least 6 months before participating study ambulated independently baseline (N = 456). Intervention Six or . Measurements Four types fall measures (falls, time to first fall,...

Abstract Background Severe hyperkalemia is a life-threatening emergency requiring prompt management and close surveillance. Although artificial intelligence-enabled electrocardiography (AI-ECG) has been developed to rapidly detect hyperkalemia, its application monitor potassium (K+) levels remains unassessed. This study aimed evaluate the effectiveness of AI-ECG for monitoring K+ in patients with severe hyperkalemia. Methods retrospective was performed at an department single medical center...

We employed a population-based cohort sample to explore the risk of coronary heart disease (CHD) in relation osteoporosis an Asian population.We designed retrospective study from 2000 2010 with data obtained Taiwan's Longitudinal Health Insurance Database. A total 19,456 patients aged 45 years or older who had no history CHD and diagnosis were identified as cohort. The comparison randomly selected frequency matched according age, sex, year index date at 1:1 ratio. Both cohorts followed until...

A prospective study was conducted to compare criterion, predictive, and construct validities of 9 fracture/osteoporosis assessment tools, including calcaneal quantitative ultrasonography (QUS), Age Bulk One or Never Estrogens (ABONE), body weight criterion (BWC), Fracture Risk Assessment Tool (FRAX), Garvan fracture risk calculator (GARVAN), Osteoporosis Instrument (ORAI), Index (OSIRIS), Self-Assessment for Asians (OSTA), Simple Calculated Estimation (SCORE), among older men women in...

Traumatic brain injury (TBI) can lead to severe adverse clinical outcomes, including death and disability. Early detection of in-hospital mortality in high-risk populations may enable early treatment potentially reduce using machine learning. However, there is limited information on prediction models for TBI patients admitted emergency departments. The aim this study was create a model that successfully predicts, from measures demographics, sample the department. Of 4881 who were screened at...

Statins constitute the mainstay treatment for atherosclerotic cardiovascular disease, which is associated with risk of new-onset diabetes mellitus (NODM). However, effects individual statins on NODM remain unclear. We recruited 48,941 patients taking one three interested in a tertiary hospital between 2006 and 2018. Among them, 8337 non-diabetic moderate-intensity (2 mg/day pitavastatin, 10 atorvastatin, rosuvastatin) were included. The pitavastatin group had higher probability being...

Thyrotoxic periodic paralysis (TPP) characterized by acute weakness, hypokalemia, and hyperthyroidism is a medical emergency with great challenge in early diagnosis since most TPP patients do not have overt symptoms.This work aims to assess artificial intelligence (AI)-assisted electrocardiography (ECG) combined routine laboratory data the of TPP.A deep learning model (DLM) based on ECG12Net, an 82-layer convolutional neural network, was constructed detect hypokalemia hyperthyroidism. The...

T cells secrete several inflammatory cytokines that play a critical role in the progression of atherosclerosis. Although green tea epigallocatechin-3-gallate (EGCG) exerts anti-inflammatory and anti-atherosclerotic effects animals, few studies have identified mechanism underlying these human primary cells. This study investigated pathway involved EGCG modulation cytokine secretion activated We pre-treated with (0.1, 1, 5, 10, 20 μM) for 4 h incubated them or without phorbol 12-myristate...

Abstract Background Few studies emphasize on predictors of incident cognitive frailty (CF) and examine relationships between various gait characteristics CF. Therefore, we conducted a 2-year prospective study to investigate potential predictors, including characteristics, reversible CF (RCF) potentially RCF (PRCF) among Taiwanese older adults. Methods Eligible participants were individuals aged ≥ 65 years, who could ambulate independently, did not have RCF/PRCF at the baseline. The baseline...

Previous studies suggest baicalein, in addition to its antioxidant effects, protects against hypoxia/reoxygenation injury via pro-oxidant properties. We hypothesize that a brief period of baicalein treatment prior ischemia/reperfusion (I/R) may trigger preconditioning protection mitochondrial mechanism. Using an established chick cardiomyocyte model I/R, cells were preconditioned with (10 μM) for 10 min followed by 10-min wash I/R. Intracellular oxidants measured using 2',...

Atherosclerosis, resulting from lipid dysregulation and vascular inflammation, causes atherosclerotic cardiovascular disease (ASCVD), which contributes to morbidity mortality worldwide. Chalcone its derivatives possess beneficial properties, including anti-inflammatory, antioxidant antitumour activity with unknown cardioprotective effects. We aimed develop an effective chalcone derivative antiatherogenic potential.Human THP-1 cells HUVECs were used as in vitro models. Western blots real-time...

A randomized trial was conducted to investigate the effects of computerized cognitive training (CCT) and tai chi exercise (TCE) vs. health education (HE) on functions in 189 older adults with mild impairment (MCI).Cognitive were assessed by five-domain Mattis Dementia Rating Scale (MDRS) (attention, initiation/perseveration, construction, conceptualization, memory) modified Telephone Interview Cognitive Status (TICS-M), while timed up go (TUG), Tinetti's balance, activities daily living...

Statins inhibiting 3-hydroxy-3-methylglutaryl-CoA reductase are the standard treatment for hypercholesterolemia in atherosclerotic cardiovascular disease (ASCVD), mediated by inflammatory reactions within vessel walls. Several studies highlighted pleiotropic effects of statins beyond their lipid-lowering properties. However, few investigated on T cell activation. This study evaluated immunomodulatory capacities three common statins, pitavastatin, atorvastatin, and rosuvastatin, activated...

(1) Background: While an artificial intelligence (AI)-based, cardiologist-level, deep-learning model for detecting acute myocardial infarction (AMI), based on a 12-lead electrocardiogram (ECG), has been established to have extraordinary capabilities, its real-world performance and clinical applications are currently unknown. (2) Methods Results: To set up intelligence-based alarm strategy (AI-S) AMI, we assembled development cohort including 25,002 visits from August 2019 April 2020...

This study investigates the effect of epigallocatechin gallate (EGCG) on white and beige preadipocyte growth explores involvement miR-let-7a/HMGA2 pathway.3T3-L1 D12 cells are treated with EGCG. The EGCG cell proliferation viability is evaluated, as well microRNA (miRNA)-related signaling pathways. inhibits 3T3-L1 growth, upregulates miR-let-7a expression, downregulates high-mobility group AT-hook 2 (HMGA2) mRNA protein levels in a time- dose-dependent manner. In addition, overexpression...

Anti-calcitonin gene-related peptide (CGRP) monoclonal antibodies have emerged as promising therapeutic options for the treatment of chronic migraine. However, response varies considerably among individuals, suggesting a potential role genetic factors. This study aimed to identify variants affecting efficacy anti-CGRP antibody therapy in migraine Han Chinese population Taiwan enhance precision and understand architecture

Foam cells are formed when macrophages imbibe low-density lipoprotein (LDL) through scavenger receptors. Here we examined how epigallocatechin-3-gallate (EGCG) influences foam cell formation. We found that EGCG dose-dependently reduced oxidized LDL (oxLDL) uptake in THP-1 (10 μM, 20.0 ± 0.50, p < 0.05) and primary (134.6 15.6, intracellular cholesterol content these cells, respectively 32.6 0.14, 0.05; 31.7 1.26, 0.05). treatment decreased receptor A expression, but not the expression of...

Coronary artery disease (CAD) rarely occurs in young adults. Our objective was to investigate the baseline characteristics and outcomes of patients with CAD.We retrospectively enrolled aged < 40 years age who underwent coronary angiography a tertiary hospital Taiwan between 2002 2015. The in-hospital acute syndrome (ACS) occlusive CAD (stenotic lesions > 50%) were compared those without ACS non-occlusive CAD, respectively.We 245 including 131 (53.5%) 178 CAD. median 36.08 mean follow-up...

Sudden cardiac arrest (SCA) is a leading cause of death in the United States. Despite return spontaneous circulation, patients die due to post-SCA syndrome that includes myocardial dysfunction, brain injury, impaired metabolism, and inflammation. No medications improve SCA survival. Our prior work suggests optimal Akt activation critical for cooling protection recovery. Here, we investigate small inhibitor PTEN, an Akt-related phosphatase present heart brain, as potential therapy improving...