A5090732781- Lipid metabolism and biosynthesis
- Endoplasmic Reticulum Stress and Disease
- Pesticide Exposure and Toxicity
- Plant biochemistry and biosynthesis
- Cholinesterase and Neurodegenerative Diseases
- Protein Kinase Regulation and GTPase Signaling
- Plant Gene Expression Analysis
- Autophagy in Disease and Therapy
- Nitrogen and Sulfur Effects on Brassica
- Adipose Tissue and Metabolism
- Photosynthetic Processes and Mechanisms
- Proteoglycans and glycosaminoglycans research
- Cancer-related molecular mechanisms research
- Immune cells in cancer
- Peroxisome Proliferator-Activated Receptors
- RNA Interference and Gene Delivery
- RNA Research and Splicing
- NF-κB Signaling Pathways
- Research in Cotton Cultivation
- Cancer, Lipids, and Metabolism
- Cellular transport and secretion
- Cancer, Hypoxia, and Metabolism
- Enzyme Catalysis and Immobilization
- Glycosylation and Glycoproteins Research
- Skin and Cellular Biology Research
Chongqing University of Posts and Telecommunications
2013-2025
Hebei Medical University
2019-2024
Xingtai People's Hospital
2019-2024
Nantong University
2022-2024
Chinese Academy of Sciences
2005-2022
Institute of Zoology
2005-2022
University of Graz
2017
Transmembrane protein 68 (TMEM68) is a recently identified mammalian triacylglycerol (TAG) synthase with high expression in the brain. How TMEM68 regulates cellular lipid metabolism concert other enzymatic pathways remains poorly understood. In this study, we assessed function neuro‐ and glioblastoma cells by combining genetic gain‐ loss‐of‐function approaches lipidomics. We found that promotes TAG synthesis droplet formation independently of canonical acyl‐CoA:diacylglycerol acyltransferase...
The incidence of clear cell renal carcinoma (ccRCC) has steadily increased over the past decade, and recent studies have linked bile acid (BA) metabolism to its development. However, metabolic profile BAs their potential as biomarkers in ccRCC pathogenesis remain poorly characterized, making evaluation crucial for advancing disease understanding management. A total 68 newly diagnosed patients 63 healthy controls were enrolled. Serum profiles measured using Ultra Performance Liquid...
Mammalian patatin-like phospholipase domain-containing proteins (PNPLAs) are lipid-metabolizing enzymes with essential roles in energy metabolism, skin barrier development, and brain function. A detailed annotation of enzymatic activities structure-function relationships remains an important prerequisite to understand PNPLA functions (patho-)physiology, for example, disorders such as neutral lipid storage disease, non-alcoholic fatty liver neurodegenerative syndromes. In this study, we...
Abstract This study focuses on the effect of miR‐129‐5p docetaxel‐resistant ( DR ) prostate cancer PC a) cells invasion, migration and apoptosis. In our study, expression CAMK 2N1 was assessed by qRT ‐ PCR in a patient tissues cell lines including ‐3 ‐3‐ . Cells transfected with mimics, inhibitor, or negative controls NC were used to interrogate their effects invasions, migrations apoptosis during docetaxel DTX treatments. The rate validated flow cytometry. Relationships between levels...
Triacylglycerol (TG) biosynthesis is an important metabolic process for intracellular storage of surplus energy, intestinal dietary fat absorption, attenuation lipotoxicity, lipid transportation, lactation and signal transduction in mammals. Transmembrane protein 68 (TMEM68) endoplasmic reticulum (ER)-anchored acyltransferase family member unknown function. In the current study we show that overexpression TMEM68 promotes TG accumulation droplet (LD) formation a conserved active...
Abstract Multicellular resistance (MCR) is produced because multicellular spheroids (MCSs) are formed with a broad cell–cell connection when cultured in three‐dimensions, which limits the clinical treatment efficacy solid tumors. Focal adhesion kinase (FAK) plays an important role apoptosis, survival and cell between cells their extracellular matrix. In this study, we investigated expressions of FAK, Akt NF‐κB human colorectal cancer (CRC), effects FAK gene silencing on MCSs formation...
NAC (NAM, ATAF1/2, and CUC2) transcription factors play an important role in plant growth development. However, tumorous stem mustard (Brassica juncea var. tumida), one of the economically crops cultivated southwest China some southeast Asian countries, reports on identification family genes are lacking. In this study, we conducted a genome-wide investigation B. tumida, based its recently published genome sequence data.The were identified tumida using bioinformatics approach whole level....
Chemotherapy resistance in solid tumors is broad and encompasses diverse unrelated drugs. Three-dimensional multicellular spheroids (MCSs) are a good model for studying vitro drug resistance. In the current study, we investigated role of focal adhesion kinase (FAK) 5-fluorouracil (5-FU) chemoresistance colon carcinoma MCS culture cells. The expression FAK was inhibited significantly by specific small hairpin RNA targeting FAK. suppression did not affect growth spheroid However, silencing...
Neuropathy target esterase (NTE) is an endoplasmic reticulum (ER)-localized phospholipase that deacylates phosphatidylcholine (PC) and lysophosphatidylcholine (LPC). Loss-of-function mutations in the human NTE gene have been associated with a spectrum of neurodegenerative disorders such as hereditary spastic paraplegia, ataxia chorioretinal dystrophy. Despite this, little known about structure–function relationships between protein domains, enzymatic activity interaction cellular organelles....
Teosinte branched1/Cycloidea/proliferating cell factors (TCPs) are plant-specific transcription widely involved in leaf development, flowering, shoot branching, the circadian rhythm, hormone signaling, and stress responses. However, TCP function Brassica juncea var. tumida, tumorous stem mustard, has not yet been reported. This study identified characterized entire family members B. tumida.We 62 BjTCP genes from tumida genome analyzed their phylogenetic relationship, gene structure, protein...
Exostosin like glycosyltransferase 3 (EXTL3) had been reported to be associated with immune deficiency and play prognostic roles in various cancers. However, little is known about the associations between EXTL3 prostate cancer (PCa). Hence, this article was designed clarify their associations.All original data were downloaded from The Cancer Genome Atlas (TCGA) database. Gene set enrichment analysis (GSEA) CellMiner database utilized, respectively, identify EXTL3-related signaling pathways...
Mammalian patatin-like phospholipase domain containing proteins (PNPLAs) play critical roles in triglyceride hydrolysis, phospholipids metabolism, and lipid droplet (LD) homeostasis. PNPLA7 is a lysophosphatidylcholine hydrolase anchored on the endoplasmic reticulum which associates with LDs through its catalytic region (PNPLA7-C) response to increased cyclic nucleotide levels. However, interaction of unknown. Herein, we demonstrate that PNPLA7-C localizes mature ex vivo also colocalizes...
Leaf senescence in tobacco is closely related to leaf maturation and secondary metabolites. Bcl-2-associated athanogene (BAG) family members are highly conserved proteins play key roles senescence, growth development, resistance biotic abiotic stresses. Herein, the BAG of was identified characterized. In total, 19 protein candidate genes were divided into two classes, class I comprising NtBAG1a–e , NtBAG3a–b NtBAG4a–c II including NtBAG5a–e NtBAG6a–b NtBAG7 . Genes same subfamily or branch...
Abstract Transmembrane protein 68 (TMEM68) is a recently identified mammalian triacylglycerol (TAG) synthase with high expression in the brain. How TMEM68 regulates cellular lipid metabolism concert other enzymatic pathways remains poorly understood. In this study, we assessed function neuro- and gliablastoma cells by combining genetic gain- loss-of-function approaches lipidomics. We found that promotes TAG synthesis droplet formation independently of canonical acyl-CoA:diacylglycerol...
Acyltransferases catalyze essential reactions in the buildup and remodeling of glycerophospholipids contribute to maintenance diversity cellular membranes. Transmembrane protein 68 (TMEM68) is an evolutionarily conserved unknown function, that forms a distinct subgroup within glycerophospholipid acyltransferase family. In current study we expressed murine TMEM68 for first time mammalian cells characterize its subcellular localization, topology, possible biological function(s). We show...