A5051746674- Venous Thromboembolism Diagnosis and Management
- Pleural and Pulmonary Diseases
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Acute Myocardial Infarction Research
- Ultrasound in Clinical Applications
- Microbial Community Ecology and Physiology
- Atrial Fibrillation Management and Outcomes
- Polynomial and algebraic computation
- Genomics and Phylogenetic Studies
- Lung Cancer Diagnosis and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cancer-related Molecular Pathways
- Central Venous Catheters and Hemodialysis
- Estrogen and related hormone effects
- Cancer Cells and Metastasis
- Acute Ischemic Stroke Management
- Protist diversity and phylogeny
- Cancer Risks and Factors
- Commutative Algebra and Its Applications
- Diagnosis and Treatment of Venous Diseases
- Numerical Methods and Algorithms
- Pneumothorax, Barotrauma, Emphysema
- Nanoparticle-Based Drug Delivery
- Toxic Organic Pollutants Impact
Universidad de Alcalá
2003-2024
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2024
Instituto Ramón y Cajal de Investigación Sanitaria
2010-2024
Hospital Universitario Ramón y Cajal
2005-2023
Discovery Institute
2016-2023
Sanford Burnham Prebys Medical Discovery Institute
2010-2023
Oregon Health & Science University
2014-2023
San Diego State University
2022
Universidad de Granada
2017-2021
Instituto Cajal
2000-2020
In vivo delivery of siRNAs designed to inhibit genes important in cancer and other diseases continues be an biomedical goal. A new nanoparticle construct that is engineered for efficient siRNA tumors now described. The comprises a 47‐nm mesoporous silica core coated with crosslinked polyethyleneimine–polyethyleneglycol copolymer, carrying against the human epidermal growth factor receptor type 2 (HER2) oncogene, coupled anti‐HER2 monoclonal antibody (trastuzumab). increase blood half‐life,...
Adenosine deaminase (ADA) can aid in the diagnosis of tuberculous pleural effusions, but false-positive findings from lymphocytic effusions have been reported. The purpose this study is to assess ADA levels nontuberculous (lymphocyte count > 50%) different aetiologies. Altogether, 410 fluid samples were consecutively selected. These included malignant (n = 221), idiopathic 76), parapneumonic 35), postcoronary artery bypass graft surgery 6), miscellaneous exudative 21) and transudative 51)....
We compared the test characteristics of shock index (SI) and simplified pulmonary embolism severity (sPESI) for predicting 30-day outcomes in a cohort 1,206 patients with objectively confirmed (PE). The primary outcome study was all-cause mortality. secondary nonfatal symptomatic recurrent venous thromboembolism (VTE) or major bleeding. Overall, 119 (9.9%) out died (95% CI 8.2–11.5%) during first month follow-up. sPESI classified fewer as low-risk (369 (31%) patients, 95% 28–33%) to SI...
We have developed a thiol-modified nanoporous silica material (SH-SAMMS) as an oral therapy for the prevention and treatment of heavy metal poisoning. SH-SAMMS has been reported to be highly efficient at capturing metals in biological fluids water. Herein, was examined efficacy safety both vitro vivo animal models detoxification metals. In simulated gastrointestinal fluids, had very high affinity (Kd) methyl mercury (MeHg(I)), inorganic (Hg(II)), lead (Pb(II)), cadmium (Cd(II)) superior...
Abstract Metastatic breast cancer is developed in about 20% to 30% of newly diagnosed patients with early-stage despite treatments. Herein, we report a novel nanoparticle platform intrinsic antimetastatic properties for the targeted delivery Polo-like kinase 1 siRNA (siPLK1). We first evaluated it triple-negative (TNBC) model, which shows high metastatic potential. PLK1 was identified as top therapeutic target TNBC cells and tumor-initiating kinome-wide screen. The consists 50-nm mesoporous...
Verticillium wilt, caused by the pathogen dahliae, is extremely devastating to olive trees (Olea europea). Currently, no successful control measure available against it. The objective of this work was evaluate antifungal activity Bacillus velezensis XT1, a well-characterized salt-tolerant biocontrol strain, highly virulent defoliating V. dahliae V024. In vitro, strain XT1 showed reduce fungal mycelium from 34 100%, depending on if assay conducted with supernatant, volatile compounds,...
// Shenda Gu 1, * , Zhi Hu Worapol Ngamcherdtrakul 2 David J. Castro Jingga Morry 1 Moataz M. Reda Joe W. Gray Wassana Yantasee Department of Biomedical Engineering, Oregon Health & Science University, Portland, Oregon, 97239, USA PDX Pharmaceuticals, LLC, These authors have contributed equally to this work Correspondence to: Gray, e-mail: grayjo@ohsu.edu Yantasee, yantasee@ohsu.edu Keywords: siRNA, HER2, trastuzumab resistance, breast cancer, nanoparticles Received: December 17,...
Bell peppers are one of the most important species consumed and cultivated in Spain. Peppers a source carotenoids phenolic compounds widely associated with biological activities such as antimicrobial, antiseptic, anticancer, counterirritant, cardioprotective, appetite stimulator, antioxidant, immunomodulator. However, undersized damaged fruits usually wasted. Thus, order to evaluate content, Box–Behnken design has been carried out optimize extraction from Capsicum annuum yellow pepper by...
Triple-negative breast cancer (TNBC) remains a disease with paucity of targeted treatment opportunities. The aryl hydrocarbon receptor (AhR) is ligand-activated transcription factor that involved in wide range physiological processes, including the sensing xenobiotics, immune function, development, and differentiation. Different small-molecule AhR ligands drive strikingly varied cellular organismal responses. In certain cancers, activation by select small molecules induces cell cycle arrest...
To study the effect that copper residues exert on bacterial communities and ability of bacteria to colonize different microhabitats in abandoned tailing dumps.We used terminal-restriction fragment length polymorphism technique, a culture-independent molecular approach based PCR amplification ribosomal genes, compare structure from samples taken at two nearby located dumps found Mediterranean-climate area central Chile. Our results show elevated available content tailings has strong community...
The primary focus of chemoprevention research is the prevention cancer using pharmacological, biological, and nutritional interventions. Chemotherapeutic approaches that have been used successfully for both treatment a number human malignancies arisen from identification specific agents appropriate molecular targets. Although drug-metabolizing enzymes historically targeted in attempts to block initial, genotoxic events associated with carcinogenic process, emerging evidence supports idea...
The objective of the study was identification predictive factors for development residual pleural thickening (RPT) in patients with parapneumonic effusion. design prospective involved investigating effusions diagnosed between March 1991 and December 2000 respiratory department Hospital Ramón y Cajal (Madrid, Spain) which is a 1,500 tertiary-care hospital. clinical radiological characteristics measurements microbiological biochemical variables fluid taken from were studied. RPT defined...
Dibenzo(a,l)pyrene (DBP) is among the most potent carcinogenic polycyclic aromatic hydrocarbons. Previously, we showed that DBP administration to pregnant mice resulted in high mortality of offspring from an aggressive T-cell lymphoma. All survive 10 months age exhibit lung tumors with multiplicity. Recombinant cytochrome P450 (cyp) 1b1 and homologue 1B1 humans activity toward metabolic activation DBP. Targeted disruption cyp1b1 gene protects against DBP-dependent cancers. Mice heterozygous...
The differentiation of stem-like tumor cells may contribute to the cellular heterogeneity breast cancers. We report propagation highly enriched mouse mammary cancer stem that retain potential differentiate both in vivo and culture their use identify chemical compounds influence self-renewal differentiation. epithelial tumor-initiating (ETICs) express lineage markers basal luminal cell lineages potential, from even single cells, generate heterogeneous tumors similar origin. ETICs can progress...
We studied the bacterial community in Rambla Salada three different sampling sites and seasons effect of salinity, oxygen pH. All samples had high diversity richness (Rr>30). The indexes analysis dendrograms obtained by DGGE fingerprint after applying Pearson´s Dice´s coefficient showed a strong influence season. Pareto-Lorenz (PL) curves Fo indicated that microbial communities were balanced despite changing environmental conditions, they can preserve their functionality. main phyla detected...