A5082060868- Viral gastroenteritis research and epidemiology
- Viral Infections and Immunology Research
- Animal Virus Infections Studies
- Hepatitis Viruses Studies and Epidemiology
- RNA modifications and cancer
- Clostridium difficile and Clostridium perfringens research
- Cancer-related molecular mechanisms research
- FOXO transcription factor regulation
- Ferroptosis and cancer prognosis
- Adipokines, Inflammation, and Metabolic Diseases
- Neurological Disease Mechanisms and Treatments
- Influenza Virus Research Studies
- Viral Infectious Diseases and Gene Expression in Insects
- Advanced Thermodynamic Systems and Engines
- Histiocytic Disorders and Treatments
- Transgenic Plants and Applications
- Traditional Chinese Medicine Studies
- Axial and Atropisomeric Chirality Synthesis
- Plant-derived Lignans Synthesis and Bioactivity
- Nutrition and Health in Aging
- Respiratory viral infections research
- Diet and metabolism studies
- SARS-CoV-2 and COVID-19 Research
- Eosinophilic Disorders and Syndromes
- Viral-associated cancers and disorders
Zhangzhou Vocational and Technical College
2023-2025
Xiamen University
2015-2025
Qingdao University
2024-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Hunan Normal University
2022
Hunan Provincial People's Hospital
2019-2022
Although several studies have demonstrated a link between obesity and cognitive function, the majority primarily utilized body mass index (BMI) waist circumference, ignoring distribution of fat. Evidence regarding association metabolic score for visceral fat (METS-VF), proposed measurement adipose tissue (VAT), with function remains limited. We mainly aimed to investigate this in older adults United States. Data were from National Health Nutrition Examination Survey (NHANES) 2011 2014....
Broadly neutralizing antibodies (bNAbs) could offer escape-tolerant and lasting protection against viral infections therefore guide development of broad-spectrum vaccines. The increasing challenge posed by evolution immune evasion intensifies the importance discovery bNAbs their underlying neutralization mechanism. Here, focusing on pivotal protein VP4 rotavirus (RV), we identify a potent bNAb, 7H13, exhibiting across diverse RV genotypes demonstrating strong prevention virus infection in...
Follicular dendritic cell (FDC) sarcoma/tumor is a rare malignant tumor of follicular cells, which considered low-grade sarcoma that can involve lymph nodes or extranodal sites. Conventional FDC sarcomas are negative for Epstein-Barr virus (EBV), whereas the inflammatory pseudotumor-like variant consistently shows EBV in neoplastic cells.We report two cases liver received 3D laparoscopic right hepatectomy and open separately.EBV probe-based situ hybridization detection immunohistochemical...
Glucose-6-phosphate isomerase (GPI) plays an important part in gluconeogenesis and glycolysis through the interconversion of d-glucose-6-phosphate d-fructose-6-phosphate, its clinical significance still remains unclear breast cancer (BRCA). We analyzed expressions GPI BRCA patients to determine prognostic values. Our results showed that expression levels were upregulated patients, a high is correlated with poor overall survival (OS) BRCA. At same time, clinicopathological characteristics,...
In attempts to develop recombinant subunit vaccines against rotavirus disease, it was previously shown that the N-terminal truncated VP8* protein, VP8-1 (aa26-231), is a good vaccine candidate when used for immunization in combination with Freund's adjuvant. However, this protein stimulated only weak immune response aluminum hydroxide as an study, nontoxic B of cholera toxin (CTB) employed intra-molecular adjuvant improve immunogenicity VP8-1. Both, and C-terminal fusion proteins, were...
Non-replicating rotavirus vaccines are an alternative strategy to improve the efficacy and safety of vaccines. The spike protein VP4, which could be enzymatically cleaved into VP8∗ VP5∗, is ideal target for development recombinant vaccine. In our previous studies, we demonstrated that truncated VP4 (aa26-476, VP4∗) a more viable vaccine candidate compared VP5∗. Here, develop human vaccine, VP4∗ proteins P[4], P[6], P[8] genotype rotaviruses were expressed. All can stimulate high levels...
Human group A rotavirus (RVA) is the leading cause of acute viral gastroenteritis in children under 5 years old worldwide. The aim this study was to investigate genotype distribution RVA Midwest China. Sentinel‐based surveillance diarrhea conducted at Children's Hospital Chongqing Medical University from 2011 2015. tested by using enzyme‐linked immunosorbent assays. partial VP4 genes and VP7 were amplified sequenced, genotyping phylogenetic analyses performed. Among 2236 stool specimens...
Group A rotaviruses (RVA) remain one of the dominant pathogens causing diarrhea in children under 5 years age worldwide, despite a sharp decrease RVA-associated and mortality since introduction rotavirus vaccines. The decreased effectiveness live attenuated vaccines, coupled with emergence new genotypes risk cross-species virus transmission, underscores necessity to develop more effective broad-spectrum In this study, we utilized nanoparticles SpyCatcher-SpyTag system effectively display...
Forkhead-box-P family include FOXP1/2/3/4 and its clinical significance still remains unclear in breast cancer (BRCA). We analysed the expressions of FOXPs BRCA patients to determine diagnostic prognostic values. Our results indicated that transcriptional levels FOXP3/4 were up-regulated patients, but FOXP2 down-regulated. No statistically significant correlation found between expression Pathologic stage. FOXP2/3 had a significantly high AUC value detection cancer, with 96.8% or 95.7%...
Non-replicating rotavirus vaccines are alternative strategies that may improve the protective efficacy of in low- and middle-income countries. The truncated spike protein VP4 (aa26-476, VP4*)was a candidate antigen for development recombinant vaccines, with higher immunogenicity compared to VP8* VP5* alone. This article describes three genotype-specific sandwich ELISAs P[4], P[6], P[8]-VP4*, which important quality control vaccine production. Our results showed detection systems had good...
Previous research has suggested a link between the onset of Alzheimer's disease (AD) and metabolic disorder; however, findings have been inconsistent. To date, majority metabolomics studies focused on AD, resulting in relative paucity early-stage conditions such as mild cognitive impairment (MCI) underexplored. In this study, we employed comprehensive platform for early screening individuals with MCI using high-throughput targeted metabolomics.
Abstract Felodipine (FEL)–tetracyanoethylene (TCNE)–2,2′-bipyridine (Bpy) complex was prepared with FEL, TCNE–Bpy and characterized by fluorescence, ultraviolet, infrared. By exploring the concentration dosage of Bpy, it found that 1 mL 2 × 10 −3 mol‧L −1 Bpy had best effect. The sequence reagent addition determined to be followed then TCNE, Bpy. FEL 2.5 −4 9.0 , which a good linear relationship fluorescence intensity. compound accuracy, precision, specificity, could used for determination...
In previous studies, we found that truncated rotavirus VP4* (aa 26-476) could be expressed in soluble form Escherichia coli and confer high protection against the mouse mode. this study, further improved immunogenicity of by polymerization. The purified was polymerized through incubation at 37 ℃ for 24 h, then homogeneity particles analyzed HPLC, TEM AUC, while thermal stability antigenicity DSC ELISA, respectively. Finally, protective efficacy polymers a maternal antibody model. results...
Reverse genetics approaches can directly manipulate the genome of virus at gene level, making it possible to quickly, and thoroughly study mechanisms replication pathogenesis. At present, many viruses family Reoviridae, such as mammalian orthoreovirus (MRV) bluetongue (BTV), have made great progress in basic viral research using powerful tool reverse genetics. However, for members genus Rotavirus construction genetic systems has been slow. The remarkable system based on helper-viruses was...
Abstract Forkhead-box-P family include FOXP1/2/3/4 and its clinical significance still remains unclear in breast cancer(BRCA). We analysed the expressions of FOXPs BRCA patients to determine diagnostic prognostic values. Our results indicated that transcriptional levels FOXP3/4 were up-regulated patients, but FOXP2 down-regulated. No statistically significant correlation found between expression Pathologic stage. FOXP2/3 had a significantly high AUC value detection cancer, with 96.8% or...