A5001430336- Asymmetric Synthesis and Catalysis
- Folate and B Vitamins Research
- Asymmetric Hydrogenation and Catalysis
- Synthetic Organic Chemistry Methods
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Microfluidic and Capillary Electrophoresis Applications
- Sulfur Compounds in Biology
- Genetics, Aging, and Longevity in Model Organisms
- Catalytic C–H Functionalization Methods
- Carbohydrate Chemistry and Synthesis
- Insurance, Mortality, Demography, Risk Management
- Chemical Synthesis and Analysis
- Lipoproteins and Cardiovascular Health
- Cyclopropane Reaction Mechanisms
- Epigenetics and DNA Methylation
- Synthesis and Catalytic Reactions
- Electrochemical sensors and biosensors
- Metabolism and Genetic Disorders
- Amino Acid Enzymes and Metabolism
- Analytical Chemistry and Chromatography
- Aging and Gerontology Research
- Metabolomics and Mass Spectrometry Studies
- Polyamine Metabolism and Applications
- Mass Spectrometry Techniques and Applications
Mid Sweden University
2012-2025
Azienda Ospedaliera G. Brotzu
2025
Yale University
2017-2021
Stockholm University
2009-2019
University of Sassari
2007-2017
University of Cagliari
1991-2017
Azienda Ospedaliero Universitaria di Sassari
2012-2013
IFC Research (United Kingdom)
2012
Bernard (Czechia)
2012
University of Milan
2012
Background: Accurate estimates of the prevalence and characteristics fetal alcohol syndrome (FAS) spectrum disorders (FASD) in a Western European population are lacking particular interest settings where usual pattern consumption is thought to be daily drinking with meals. To address these issues, an epidemiology study FAS other FASD was undertaken Italian schools. Methods: Primary schools ( n =25) 2 health districts Lazio region were randomly selected recruited for study. Five hundred...
Clear evidence exists for heritability of human longevity, and much interest is focused on identifying genes associated with longer lives. To identify such longevity alleles, we performed the largest genome-wide linkage scan thus far reported. Linkage analyses included 2118 nonagenarian Caucasian sibling pairs that have been enrolled in 15 study centers 11 European countries as part Genetics Healthy Aging (GEHA) project. In joint analyses, observed four regions show longevity; chromosome...
MicroRNAs (miRNAs) represent a family of small non-coding ribonucleic acids that post-transcriptionally inhibits the expression their target messenger RNAs (mRNAs), thereby acting as general gene repressors. In this study we examined relative quantity and stability miRNA subjected to long period freezing; compared eight miRNAs in plasma five human healthy controls before freezing after six 12 months storage at −80 °C. addition, frozen for 14 years amount still available. Using Life...
Abstract The first examples of one‐pot highly chemo‐ and enantioselective dynamic kinetic asymmetric transformations (DYKATs) involving α,β‐unsaturated aldehydes propargylated carbon acids are presented. These DYKATs, which proceed by a combination catalytic iminium activation, enamine Pd 0 ‐catalyzed enyne cycloisomerization, give access to functionalized cyclopentenes with up 99 % ee can be used for the generation all‐carbon quaternary stereocenters.
Summary To re‐examine the correlation between mt DNA variability and longevity, we examined s from samples obtained over 2200 ultranonagenarians (and an equal number of controls) collected within framework GEHA EU project. The were categorized by high‐resolution classification, while about 1300 molecules (650 completely sequenced. Sequences, unlike standard haplogroup analysis, made possible to evaluate for first time cumulative effects specific, concomitant mutations, including those that...
The development, scope, and application of the highly enantioselective organocatalytic aziridination α,β-unsaturated aldehydes is presented. aminocatalytic azirdination enables asymmetric formation β-formyl aziridines with up to >19:1 d.r. 99% ee. α-monosubstituted enals gives access terminal α-substituted-α-formyl in high yields In case disubstituted aldehydes, transformations were diastereo- give nearly enantiomerically pure β-formyl-functionalized aziridine products (99% ee). A one-pot...
In control: The first dynamic one-pot three-component asymmetric transformation between aldehydes, protected α-cyanoglycine esters, and enals catalyzed by a combination of simple hydrogen-bond-donating catalyst chiral amine is disclosed. Polysubstituted proline derivatives, which have quaternary α stereocenter, were synthesized with high endo-, diastereo-, enantioselectivities (93–99 % ee). Detailed facts importance to specialist readers are published as "Supporting Information". Such...
Head and neck paragangliomas (HNPGLs) are neural crest-derived tumors. In comparison with located in the abdomen chest, which generally catecholamine secreting (sPGLs) sympathetic origin, HNPGLs are, fact, parasympathetic origin nonsecreting. Overall, 79 consecutive patients HNPGL were examined for mutations SDHA, SDHB, SDHC, SDHD, SDHAF2, VHL, MAX, TMEM127 genes by PCR/sequencing. According to a detailed family history (FH) clinical, laboratory (including metanephrines), instrumental...
Into the pot: A one-pot highly chemo- and enantioselective catalytic domino oxa-Michael/carbocyclization between α,β-unsaturated aldehydes propargylic alcohols is presented. This dynamic kinetic transformation requires a combination of transition-metal amine catalysis to afford functionalized dihydrofurans in good high yields up 99.5:0.5 e.r. Detailed facts importance specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset....
Branching out! The first co-catalytic enantioselective (up to 98:2 e.r.) β-alkylation of α,β-unsaturated aldehydes by combination simple chiral amine and copper catalysts provides β-branched in a one-pot protocol (see scheme). methodology was applied the short total syntheses bisabolane sesquiterpenes (S)-(+)-curcumene, (E)-(S)-(+)-3-dehydrocurcumene (S)-(+)-tumerone. Detailed facts importance specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not...
A highly chemo- and enantioselective organocatalytic addition of fluorocarbon nucleophiles, such as 1-fluoro-bis(phenylsulfonyl)methane, to α,β-unsaturated aldehydes is presented (see scheme). The reactions are catalyzed by simple chiral amines give access optically active fluorine derivatives in good yields up 95 % ee. Notably, the methodology can be applied formation a quaternary carbon center bearing atom with high enantioselectivity. Detailed facts importance specialist readers published...
A simple and direct method for derivatization of solid polysaccharides is presented. The novel methodology based on the combination organic acid-catalyzed esterification or etherification photochemical thiol-ene click a heterogeneous polysaccharide. cellulose was "organoclick" modified with aryl, alkyl polyester groups, respectively. modification allows highly modular metal free surface polysaccharides.
Polysubstituted 5- and 6-membered carbocycles were synthesized by the title reaction. The one-pot dynamic relay process generates four new stereocenters, including a quaternary carbon center, in highly enantioselective fashion (99.5:0.5→99:0.5 e.r.) using simple combination of palladium chiral amine co-catalysts.
Herein is described a versatile and broad synergistic strategy for expansion of chemical space the synthesis valuable molecules (e.g. carbocycles heterocycles), with up to three quaternary stereocenters, in highly enantioselective fashion from simple alcohols (31 examples, 95:5 >99.5:0.5 e.r.) using integrated heterogeneous metal/chiral amine multiple relay catalysis air/O₂ as terminal oxidant. A novel 1,4-selective metal/amine co-catalyzed hydrogenation enals was also added sequences.
Abstract A modular design for a novel heterogeneous synergistic catalytic system, which simultaneously activates the electrophile and nucleophile by combined activation modes of separate metal non‐metal catalyst, asymmetric cascade transformations on solid surface is disclosed. This catalysis strategy generates carbocycles (up to 97.5:2.5 er ) as well spirocyclic oxindoles (97.5:2.5 >99:0.5 ), containing all‐carbon quaternary centers, in highly enantioselective fashion via one‐pot dynamic...
The concept of combining heterogeneous transition metal and amine catalysis for enantioselective cascade reactions has not yet been realized. This is great advantage since it would allow the recycling expensive non-environmentally friendly metals. We disclose that use a Pd-catalyst in combination with simple chiral co-catalyst allows highly transformations. preparative power this process demonstrated context asymmetric Michael/carbocyclization transformations delivers cyclopentenes bearing...
This study examined the effect of storage temperature on protein profile human plasma. Plasma samples were stored for 13 days at -80°C, -20°C, +4°C and room (20-25°C) prior to proteomic analysis. The comparisons based differences mean intensity values spots between fresh plasma (named "time zero") different temperatures. To better understand thermally induced biochemical changes that may affect proteins during we identified with expressions respect time zero sample.Using two-dimensional...