A5062579001- Cardiac electrophysiology and arrhythmias
- Neuroscience and Neural Engineering
- Ion channel regulation and function
- Peroxisome Proliferator-Activated Receptors
- Metabolism, Diabetes, and Cancer
- Cardiac pacing and defibrillation studies
- Cardiomyopathy and Myosin Studies
- Reproductive Physiology in Livestock
- Bioactive Compounds and Antitumor Agents
- Cell Adhesion Molecules Research
- Cholesterol and Lipid Metabolism
- Lipid metabolism and disorders
- Diet and metabolism studies
- Osteoarthritis Treatment and Mechanisms
- Adipose Tissue and Metabolism
- Ruminant Nutrition and Digestive Physiology
- Neuroscience and Neuropharmacology Research
- Neurological disorders and treatments
- Genetic and phenotypic traits in livestock
- Bone health and treatments
- Cancer, Lipids, and Metabolism
- Cardiovascular Effects of Exercise
- Ophthalmology and Eye Disorders
- Botulinum Toxin and Related Neurological Disorders
- Liver Disease Diagnosis and Treatment
Laboratory Signaling and Cardiovascular Pathophysiology
2021-2023
Université Paris-Saclay
2021-2022
Inserm
2021
Institut Galien Paris-Saclay
2021
Jilin University
2013-2015
Jilin Medical University
2013
Background/Aims: ß-hydroxybutyrate (BHBA) is the major component of ketone bodies in ketosis. Dairy cows with ketosis often undergo oxidative stress. BHBA related to inflammation involved other diseases dairy cattle. However, whether can induce inflammatory injury cow hepatocytes and potential mechanism this induction are not clear. The NF-κB pathway plays a vital role response. Methods: Therefore, study evaluated stress, pro-inflammatory factors cultured calf treated different...
The effect of acetic acid on hepatic lipid metabolism in ruminants differs significantly from that monogastric animals. Therefore, the aim this study was to investigate regulation mechanism dairy cows. AMP-activated protein kinase (AMPK) signaling pathway plays a key role regulating metabolism. In vitro, bovine hepatocytes were cultured and treated with different concentrations sodium acetate (neutralized acid) BML-275 (an AMPKα inhibitor). Acetic consumed large amount ATP, resulting an...
Rationale: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare disease, manifested by syncope or sudden death in children young adults under stress conditions. Mutations the Ca 2+ release channel/RyR2 (type 2 ryanodine receptor) gene account for about 60% of identified mutations. Recently, we found and described mutation RyR2 N-terminal domain, R420Q . Objective: To determine arrhythmogenic mechanisms this mutation. Methods Results: Ventricular tachycardias conditions were...
β-hydroxybutyric acid (BHBA), an important metabolite in β-oxidation, is involved the development of ketosis dairy cows. It known that AMP-activated protein kinase (AMPK) signaling pathway plays role regulation lipid metabolism hepatocytes. In present study, bovine hepatocytes were treated with BHBA at variable concontrations and Compound C (Cpd C, AMPK inhibitor) to investigate effects on pathway. The results showed when concentration reached 1.2 mM, was activated expression sterol...
Background: Fatty liver is a major metabolic disorder that occurs during early lactation in high-producing dairy cows. Sterol regulatory element-binding protein-1c (SREBP-1c) an important transcription factor regulates lipid synthesis by regulating the expression of metabolism genes. Methods: In this study, we reduced SREBP-1c adenovirus-mediated with low vector (AD-GFP-SREBP-1c) to study effects on deposits bovine hepatocytes. The levels and enzyme activities SERBP-1c its target genes were...
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is triggered by exercise or acute emotion in patients with normal resting electrocardiogram. The major disease-causing gene RYR2, encoding the cardiac ryanodine receptor (RyR2). We report a novel RYR2 variant, p.Asp3291Val, outside four CPVT mutation hotspots, three families numerous sudden deaths. This missense variant was first identified four-generation family, where eight deaths occurred before age of 30 context adrenergic...
Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main source(s): ANR (Agence Nationale de la Rercherche) Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a lethal genetic arrhythmia that manifests by syncope or sudden death in children and young adults under stress conditions without obvious cardiac structural abnormality. A novel CPVT mutation located the RyR2 N terminal portion has been identified Spanish family (RyR2R420Q)....