A5073886077- Reproductive System and Pregnancy
- RNA Research and Splicing
- Endometriosis Research and Treatment
- RNA modifications and cancer
- Genomics and Chromatin Dynamics
- DNA and Nucleic Acid Chemistry
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Advanced biosensing and bioanalysis techniques
- Reproductive Physiology in Livestock
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Preterm Birth and Chorioamnionitis
- Osteoarthritis Treatment and Mechanisms
- Lipid metabolism and disorders
- RNA Interference and Gene Delivery
- Fungal Plant Pathogen Control
- Bone Metabolism and Diseases
- Phytochemical compounds biological activities
- Crystallography and molecular interactions
- Gynecological conditions and treatments
- Circular RNAs in diseases
- Angiogenesis and VEGF in Cancer
- Asymmetric Hydrogenation and Catalysis
- MicroRNA in disease regulation
Northeast Forestry University
2017-2025
University of Shanghai for Science and Technology
2024
Ministry of Education of the People's Republic of China
2024
Baise University
2021
Jilin University
2012-2020
Nanjing Agricultural University
2015-2017
Jilin Medical University
2012-2015
Rutgers, The State University of New Jersey
2015
Background/Aims: ß-hydroxybutyrate (BHBA) is the major component of ketone bodies in ketosis. Dairy cows with ketosis often undergo oxidative stress. BHBA related to inflammation involved other diseases dairy cattle. However, whether can induce inflammatory injury cow hepatocytes and potential mechanism this induction are not clear. The NF-κB pathway plays a vital role response. Methods: Therefore, study evaluated stress, pro-inflammatory factors cultured calf treated different...
Chirality greatly influences the biological and pharmacological properties of a pesticide will contribute to unnecessary environmental loading undesired ecological impact. No structure activity relationship (SAR) enantiopure succinate dehydrogenase inhibitors (SDHIs) was documented during optimization boscalids. On basis commercial SDHIs, oxazoline natural products, versatile ligands in organic synthesis, first effort devoted explore chiral SDHIs preliminary mechanism thereof. Fine-tuning...
Abstract As an oncogenic transcription factor, Yin Yang 1 (YY1) regulates enhancer and promoter connection. However, gaps still exist in understanding how YY1 coordinates coactivators chromatin elements to assemble enhancers super-enhancers. Here, we demonstrate that a histidine cluster YY1’s transactivation domain is essential for its formation of phase separation condensates, which can be extended additional proteins. The also required YY1-promoted cell proliferation, migration,...
Abstract G-quadruplexes (G4s) can recruit transcription factors to activate gene expression, but detailed mechanisms remain enigmatic. Here, we demonstrate that G4s in the CCND1 promoter propel motility MAZ phase-separated condensates and subsequently transcription. Zinc finger (ZF) 2 of is a responsible for G4 binding, while ZF3-5, not highly disordered region, critical condensation. nuclear puncta overlaps with signals various coactivators including BRD4, MED1, CDK9 active RNA polymerase...
Abstract Early growth response gene 1 (Egr1), a zinc finger transcriptional factor, plays an important role in regulating cell proliferation, differentiation and angiogenesis. Current data have shown that Egr1 is involved follicular development, ovulation, luteinization placental However, the expression, regulation function of mouse uterus during embryo implantation decidualization are poorly understood. Here we showed was strongly expressed subluminal stroma surrounding implanting...
Thymoquinone (TQ) is a natural compound extracted from the black seeds of Nigella sativa Linn. belonging to Ranunculaceae family. TQ exhibits anti-inflammatory and antineoplastic activities against various cancers. Many therapeutics in hepatocellular carcinoma (HCC) treatments, such as doxorubicin (DOX) cisplatin (DDP), exhibit considerable side effects on patients. We investigated cytotoxic TQ, alone or combination with DDP DOX HCC cells. exhibited selective killing HepG2 SMMC-7721 cells,...
Polydatin (PD) is a natural compound with anticancer activities, but the underlying mechanisms remain largely unclear. To understand how PD inhibited hepatocellular carcinoma (HCC), we studied treatments in HCC HepG2 and SK-HEP1 cells, normal liver HL-7702 cells. selectively blocked proliferation of cells showed low toxicity while effects doxorubicin (DOX) cisplatin (DDP) on were opposite. In cotreatment studies, synergistically improved inhibitory activities DOX DDP alleviated their...
Competitive endogenous RNAs (ceRNAs) absorb microRNAs and subsequently promote corresponding mRNA long noncoding RNA (lncRNA) expression, which may alter cancer cell malignancy. Thus, dissecting ceRNA networks reveal novel targets in therapies. In this study, we analyzed differentially expressed genes (DEGs) of mRNAs lncRNAs, (DE-miRNAs) circular (DE-circRNAs) extracted from high-throughput sequencing datasets hepatocellular carcinoma patients. Based on these data, identified 26 gene modules...
Enhancer of zeste homolog 2 (EZH2) is a methyltransferase to mediate lysine 27 trimethylation in histone H3 (i.e., H3K27me3) and repress gene expression. In solid tumors, EZH2 promotes oncogenesis considered therapeutic target. As transcription factor, Yin Yang 1 (YY1) recruits through its oncoprotein binding (OPB) domain establish repression. this study, we mapped the YY1 protein (YPB) on region amino acids. Both YPB OPB synthetic peptides could disrupt YY1EZH2 interaction, markedly reduce...
Lung adenocarcinoma (LUAD) is the leading cause of cancer-related death worldwide, but underlying molecular mechanisms remain largely unclear. The transcription factor (TF) specificity protein 1 (SP1) plays a crucial role in development various cancers, including LUAD. Recent studies have indicated that master TFs may form phase-separated macromolecular condensates to promote super-enhancer (SE) assembly and oncogene expression. In this study, we demonstrated SP1 undergoes phase separation...
With structural diversity and versatile biological properties, drimane meroterpenoids have drawn remarkable attention in drug development. The stagnant progress made the structure optimization SAR study of this kind natural product for agrochemicals was mainly a result inefficient construction. Compared with reported challenging coupling reaction ("1 + 1" tactic), "carbon assimilation" conceived used rapid construction drimanyl meroterpenoid mimics, which newly formed covalent bond directly...
The efficient synthesis and antifungal exploration of (+)-yahazunol related natural products are described. Central to this strategy is the Barton decarboxylative coupling, comprising a one-pot radical decarboxylation quinone addition cascade. scalable was accomplished in five longest linear sequences (LLS) starting from commercially available inexpensive (-)-sclareol. divergent translational potential demonstrated by expedient preparation (-)-zonarone, (-)-isozonarone, (-)-zonarol,...
G-quadruplexes (G4s) regulate DNA replication and gene transcription, are enriched in promoters without fully appreciated functional relevance. Here we show high selection pressure on putative G4 (pG4) forming sequences through investigating genetic genomic data. Analyses of 76,156 whole-genome reveal that G-tracts connecting loops promoter pG4s display lower or higher allele frequencies, respectively, than pG4-flanking regions, central guanines (Gs) other Gs. Additionally, pG4-promoters...
Tryptophan 2,3-dioxygenase (Tdo2) is a rate-limiting enzyme which directs the conversion of tryptophan to kynurenine. The aim this study was examine expression and regulation Tdo2 in mouse uterus during decidualization. mRNA mainly expressed decidua on days 6-8 pregnancy. By real-time PCR, high level observed uteri from 6 8 pregnancy, although 1-8. Simultaneously, also detected under vivo vitro artificial Estrogen, progesterone, 8-bromoadenosine-cAMP could induce ovariectomized uterine...