A5081144886- Childhood Cancer Survivors' Quality of Life
- Chemotherapy-induced cardiotoxicity and mitigation
- Adolescent and Pediatric Healthcare
- Family Support in Illness
- Acute Lymphoblastic Leukemia research
- Cancer survivorship and care
- Neuroblastoma Research and Treatments
- Lymphoma Diagnosis and Treatment
- Pharmacogenetics and Drug Metabolism
- Hematopoietic Stem Cell Transplantation
- Sarcoma Diagnosis and Treatment
- Neutropenia and Cancer Infections
- Cardiac Imaging and Diagnostics
- Reproductive Biology and Fertility
- Pharmaceutical studies and practices
- Genomics and Rare Diseases
- Cardiovascular Function and Risk Factors
- Assisted Reproductive Technology and Twin Pregnancy
- Cancer Genomics and Diagnostics
- Cardiovascular and exercise physiology
- Health Systems, Economic Evaluations, Quality of Life
- Acute Myeloid Leukemia Research
- Cystic Fibrosis Research Advances
- PARP inhibition in cancer therapy
- Cardiovascular Effects of Exercise
Murdoch Children's Research Institute
2016-2025
The University of Melbourne
2013-2025
Royal Children's Hospital
2016-2025
Stem Cells Australia
2023-2024
The Royal Melbourne Hospital
2024
Royal Hospital for Sick Children
2024
Maidstone and Tunbridge Wells NHS Trust
2021-2022
Christ University
2020
Peter MacCallum Cancer Centre
2010-2019
Southern California Institute of Architecture
2016
Sarcomas are a group of heterogeneous tumours with varying genetic basis. Cytogenetic abnormalities range from distinct genomic rearrangements such as pathognomonic translocation events and common chromosomal amplification or loss, to more complex involving multiple chromosomes. The different subtypes liposarcoma spread across this spectrum constitute an interesting tumour type for molecular review. This paper will outline pathogenesis the three main liposarcoma:...
Introduction A pandemic coronavirus, SARS-CoV-2, causes COVID-19, a potentially life-threatening respiratory disease. Patients with cancer may have compromised immunity due to their malignancy and/or treatment, and be at elevated risk of severe COVID-19. Community transmission COVID-19 could overwhelm health care services, compromising delivery care. This interim consensus guidance provides advice for clinicians managing patients during the pandemic. Main recommendations During pandemic: In...
ABSTRACT Pharmacogenomics is a field of personalized medicine that aims to tailor drug dosing based on the genetics an individual. The polymorphic and complex CYP2D6 gene important analyze because its role in metabolism approximately quarter all drugs. Several bioinformatic tools have been developed genotype from short‐read sequencing data. Among these, Cyrius, tool specifically designed for genotyping, has demonstrated high performance across various datasets. However, Cyrius not updated...
This study investigated the efficacy of a pre-emptive strategy based on combination Epstein-Barr virus (EBV) viraemia and poor T cell reconstitution in preventing post-transplant lymphoproliferative disease (PTLD) following depleted stem transplant (SCT). EBV viral load immune were prospectively monitored 70 consecutive children undergoing SCT reduced intensity conditioning with alemtuzumab. Patients who developed significant (> 40 000 copies/ml blood) treated pre-emptively rituximab if they...
Over 18 million people worldwide were diagnosed with cancer in 2020, including over 150,000 Australia. Although improved early detection and treatment have increased the survival rates, cardiotoxic inadequate management of cardiovascular risk factors resulted disease (CVD) being one leading causes non-cancer-related death disability among survivors. International guidelines outline standards care for CVD surveillance management. However, Australian cardio-oncology policies clinical are...
Abstract Background Delirium is common in older inpatients, causing distress, cognitive decline, and death. Current therapies are unsatisfactory, limited by lack of efficacy adverse effects. There an urgent need for effective delirium treatment. Sleep wake cycle disturbed delirium; endogenous Melatonin perturbed, exogenous a safe medication sleep disorders. This study aims to determine the effect oral 5 mg immediate release (IR) nightly five nights on severity (≥65 years) medical inpatients....
An adaptive platform trial (APT) offers the ability to incorporate several research questions, in same target population, across multiple domains (interventions), with add new questions a perpetual manner. APT is particularly appealing for paediatric haematopoietic stem cell transplant (HCT); an area of high heterogeneity, limited availability and mortality. Ideally, all APT, would have primary endpoint. Therefore, ordinal endpoint categories that combines various clinical outcomes into...
Background: Haematopoietic stem cell transplant (HCT) is a curative therapy for various paediatric conditions but associated with significant morbidity and mortality, particularly in children requiring intensive care, facing delayed immune reconstitution or prolonged viral reactivation. Due to the rarity heterogeneity of HCT, traditional randomised controlled trials are challenging. Adaptive platform (APTs), which evaluate multiple interventions across subgroups, offer solution , typically...
Background/Objectives: Parents of children with acute lymphoblastic leukaemia (ALL) experience emotional distress throughout their child’s treatment course. This study describes the psychological Australian and New Zealand parents diagnosed ALL. Methods: prospective, longitudinal assessed distress, anxiety, depression, anger need for help in newly ALL across eight sites between October 2018 November 2022. Psychological symptoms were quantified using Emotion Thermometer (ET) tool...
Purpose: This study investigated the impact of fertility-related discussions on Adolescent and Young Adult (AYA) cancer patients' quality life (QoL) factors influencing provision these discussions.Methods: Recruitment was conducted through population-based state registries. Eligible AYAs were 15–24 years at diagnosis, 3–24 months postdiagnosis, with any (except early stage melanoma). As part a larger survey, asked about their experiences QoL (FACT-G).Results: Of 207 returning surveys (29%...
Background/Aim The aim of this study was to describe the time and documentation needed gain ethics governance approvals in Australian states with without a centralised ethical review system. Methods This is prospective descriptive undertaken between February 2012 March 2015. Paediatric adult hospitals ( n = 67) were approached allow their medical records. Participants included 15‐ 24‐year‐olds diagnosed cancer 2008 2012. main outcomes measures (weeks) approval for number type documents...
Pediatric cancer survivors are at increased risk of cardiac dysfunction and heart failure. Reduced peak oxygen consumption (peak VO2) is associated with impaired reserve (defined as the increase in function from rest to exercise) failure risk, but it unclear whether this relationship exists pediatric survivors. This study sought investigate presence reduced VO2 failure, assess its resting haemodynamics systolic during exercise. Twenty (8–24 years; 10 male) treated anthracycline chemotherapy...
Abstract Background While several studies have examined the treatment of adolescents and young adults (AYAs) with acute lymphoblastic leukemia (ALL), myeloid (AML) are rare. Using national data for Australia, we describe (i) number type centers caring AYAs, (ii) induction/first‐line treatments, (iii) survival outcomes. Procedure National population‐based study assessing 15‐ to 24‐year‐olds diagnosed ALL or AML between 2007 2012. Treatment details were abstracted from hospital medical...
Adoptive T-cell immunotherapy holds great promise for the treatment of viral complications in immunocompromised patients resistant to standard anti-viral strategies. We present a retrospective analysis 78 from 19 hospitals across Australia and New Zealand, treated over last 15 years with "off-the-shelf" allogeneic T cells directed combination Epstein–Barr virus (EBV), cytomegalovirus (CMV), BK polyomavirus (BKV), John Cunningham (JCV) and/or adenovirus (AdV) under Australian Therapeutic...