A5030180908- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Advanced MRI Techniques and Applications
- Angiogenesis and VEGF in Cancer
- Atomic and Subatomic Physics Research
- Cardiac pacing and defibrillation studies
- Tuberculosis Research and Epidemiology
- Cardiac Imaging and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Anesthesia and Sedative Agents
- Cardiac Fibrosis and Remodeling
- Tracheal and airway disorders
- Diagnosis and treatment of tuberculosis
- Anesthesia and Neurotoxicity Research
- Lung Cancer Diagnosis and Treatment
- Psoriasis: Treatment and Pathogenesis
- Cancer Diagnosis and Treatment
- Neurological disorders and treatments
- Cancer, Hypoxia, and Metabolism
- Genetic Neurodegenerative Diseases
- Cytokine Signaling Pathways and Interactions
- Cardiovascular Function and Risk Factors
- Cardiovascular Syncope and Autonomic Disorders
- Medical Imaging and Pathology Studies
Istituto Dermopatico dell'Immacolata
2004-2022
Istituti di Ricovero e Cura a Carattere Scientifico
2001-2022
Temple University Hospital
2006
American Association of Neuropathologists
2006
Society of Critical Care Medicine
2006
Mario Negri Institute for Pharmacological Research
2000
Università Cattolica del Sacro Cuore
1989-1996
Sapienza University of Rome
1996
Johns Hopkins University
1995-1996
Johns Hopkins Medicine
1996
MicroRNAs (miRNAs) are noncoding RNAs that act as negative regulators of gene expression. Interestingly, specific alterations miRNA expression have been found in failing hearts different etiologies. The aim this study was to identify the pattern peripheral blood mononuclear cells (PBMCs) derived from chronic heart failure (CHF) patients affected by ischemic (ICM) and nonischemic dilated (NIDCM) cardiomyopathy. profile 257 miRNAs assessed 7 NIDCM patients, 8 ICM 9 control subjects...
Abstract —Endothelial cells are exposed to an acidotic environment in a variety of pathological and physiological conditions. However, the effect acidosis on endothelial cell function is still largely unknown, it was evaluated present study. Bovine aortic (BAECs) were grown bicarbonate buffer equilibrated either with 20% CO 2 (pH 7.0, acidosis) or 5% 7.4, control). Acidosis inhibited BAEC proliferation 10% FCS, whereas by day 7 serum-free medium, number 3-fold higher than control cells....
Aims HMGB1 injection into the mouse heart, acutely after myocardial infarction (MI), improves left ventricular (LV) function and prevents remodeling. Here, we examined effect of in chronically failing hearts. Methods Results Adult C57 BL16 female mice underwent coronary artery ligation; three weeks later 200 ng or denatured (control) were injected peri-infarcted region Four treatment, both echocardiography hemodynamics demonstrated a significant improvement LV HMGB1-treated mice. Further,...
BACKGROUND: Desflurane in neurosurgery may be beneficial because it facilitates postoperative early neurologic evaluation. However, its use has been debated of capacity to promote cerebral vasodilatation. Sevoflurane extensively used neurosurgical patients. In this prospective clinical trial, we compared recovery and cognitive function patients undergoing craniotomy for supratentorial expanding lesions receiving sevoflurane or desflurane anesthesia. METHODS: One hundred twenty patients, ASA...
Abstract Background Several cytokines are associated with the development and/or progression of chronic heart failure (CHF). Our aim was to look more closely at cytokine networks involved in CHF, and assess whether disease etiology affects expression. The study population comprised a) 69 patients stable New York Heart Association (NYHA) II/IV classes, secondary ischaemic (ICM) non dilated (NIDCM) cardiomyopathy b) 16 control subjects. We analyzed compared plasma levels 27 pro-...
After endovascular injury, smooth muscle cells (SMCs) may be exposed to hemodynamic shear stress (SS), and these forces modulate neointima accumulation. The effect of SS on SMC migration invasion is unknown, it was examined in the present study.Bovine aortic SMCs were laminar 12 dyne/cm(2) for 3 (SS3) or 15 (SS15) hours; control (C3 C15) kept under static conditions. Platelet-derived growth factor (PDGF)-BB-directed evaluated by a modified Boyden chamber assay with filters coated either...
Intracellular signaling pathways activated by both PDGF and basic fibroblast growth factor (bFGF) have been implicated in the migration of vascular smooth muscle cells (VSMC), a key step pathogenesis many diseases. We demonstrate here that, while bFGF is weak chemoattractant for VSMCs, it required PDGF-directed VSMCs activation calcium/calmodulin-dependent protein kinase II (CamKinase II), an intracellular event that we previously shown to be important regulation VSMC migration. Neutralizing...
To evaluate the possibility that parkinsonian signs may be only presenting feature of multiple system atrophy (MSA), patients were studied who had no atypical clinical and symptoms autonomic dysfunction, but reported they not experienced anticipated good response to dopaminergic treatment. These stringent criteria identified 20 from a series 298 consecutive outpatients. The following pointers analysed: (a) rate disease progression; (b) symmetry signs; (c) occurrence resting tremor during...
The present study was aimed at identifying chronic heart failure (CHF) biomarkers from peripheral blood mononuclear cells (PBMCs) in patients with ischemic (ICM) and nonischemic dilated (NIDCM) cardiomyopathy. PBMC gene expression profiling performed by Affymetrix two patient groups, 1) ICM ( n = 12) 2) NIDCM New York Heart Association (NYHA) III/IV CHF patients, vs. 3) age- sex-matched control subjects 12). Extracted RNAs were then pooled hybridized to a total of 11 microarrays. Gene...
Psoriasis is a chronic inflammatory skin disease associated with reactive oxygen species (ROS) increase and higher risk of cardiovascular (CV) events. We previously showed that the miR-200 family (miR-200s) induced by ROS, miR-200c being most upregulated member responsible for apoptosis, senescence, ROS increase, nitric oxide decrease, finally causing endothelial dysfunction. Moreover, circulating increases in familial hypercholesterolemic children plaques plasma atherosclerotic patients,...
In diabetic patients and animal models of diabetes mellitus (DM), circulating endothelial progenitor cell (EPC) number is lower than in normoglycaemic conditions EPC angiogenic properties are inhibited. Stromal derived factor-1 (SDF-1) plays a key role bone marrow (BM) c-kitϩ stem mobilization into peripheral blood (PB), recruitment from PB ischemic tissues differentiation cells.The aim the present study was to examine effect DM vivo vitro, on murine BM-derived c-kit ϩ cells their response...
In diabetic patients and animal models of diabetes mellitus (DM), circulating endothelial progenitor cell (EPC) number is lower than in normoglycaemic conditions EPC angiogenic properties are inhibited. Stromal derived factor-1 (SDF-1) plays a key role bone marrow (BM) c-kitϩ stem mobilization into peripheral blood (PB), recruitment from PB ischemic tissues differentiation cells.The aim the present study was to examine effect DM vivo vitro, on murine BM-derived c-kit ϩ cells their response...
Background Left ventricular remodeling after infarction is accompanied by dysfunction of regions adjacent to the infarct. We hypothesized that myocyte contractile abnormalities and elongation greater than in remote underlie adjacent-region remodeled ventricle. The activation tyrosine kinase pathway, which mediates vitro hypertrophy stretch and/or angiotensin, was also assessed myocytes separately isolated from regions. Methods Results ECG-gated magnetic resonance imaging short-axis images...
This prospective study was performed to compare the incidence of complications occurring after neurosurgical procedures in patients anesthetized with either sevoflurane-fentanyl or propofol-remifentanil anesthesia. We enrolled 162 American Society Anesthesiologists (ASA) I III (82 females and 80 males, Glasgow 15) undergoing elective procedures. Anesthesia conducted using (T group; n=80 patients) (S n=82 patients). All were monitored postanesthesia care unit for 6 hours extubation. analyzed...
BACKGROUND: Ketorolac tromethamine (ketorolac) is a nonsedating drug with potent analgesic and moderate anti-inflammatory activity, which does not increase the sedation level. The safety of ketorolac respect to risk bleeding has been demonstrated in large numbers patients undergoing general surgery, yet comparable data for neurosurgical are lacking. We studied symptomatic requiring surgery elective procedures who received as therapy. METHODS: established cohort had intracranial from January...
Since 1985, magnetocardiographic (MCG) mapping has been carried out in patients with severe ventricular arrhythmias, related to primary cardiomyopathy and ischaemic heart disease, for the purpose of non-invasive localization arrhythmogenic substrate or screen at risk sudden death. Data reported by several authors have demonstrated that magnetocardiography is useful investigate non-invasively some possible electrogenetic abnormalities underlying clinical arrhythmias identify death through...
Abstract Background Doxorubicin (Dox) is an anti-cancer anthracycline drug that causes double-stranded DNA breaks. It highly effective against several types of tumours; however, it also has adverse effects on regenerative populations normal cells, such as human cardiac mesenchymal progenitor cells (hCmPCs), and its clinical use limited by cardiotoxicity. Another known effect Dox nucleolar disruption, which triggers the ubiquitously expressed phosphoprotein Nucleophosmin (NPM) to be released...
We previously showed that genotoxic stress induced an active extracellular release of nucleophosmin (NPM) in human cardiac mesenchymal progenitor cells, and serum deprivation provokes NPM secretion from endothelial eliciting inflammation via nuclear factor kappa B (NF-kB) transcriptional activation. In this study, we wanted to determine whether was similarly modulated the skin plasma psoriatic patients (Pso). found 6 biopsies compared normal markedly increased lesional (LS) vs. non-lesional...