A5010822084- Autophagy in Disease and Therapy
- Extracellular vesicles in disease
- Essential Oils and Antimicrobial Activity
- Listeria monocytogenes in Food Safety
- Immune cells in cancer
- Bacterial biofilms and quorum sensing
- Histone Deacetylase Inhibitors Research
- Heme Oxygenase-1 and Carbon Monoxide
- Botanical Studies and Applications
- Cell Adhesion Molecules Research
- Congenital heart defects research
- Lipid metabolism and disorders
- Cardiovascular Effects of Exercise
- Parkinson's Disease Mechanisms and Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cardiac Fibrosis and Remodeling
- Advanced Technologies in Various Fields
- Calpain Protease Function and Regulation
- Eosinophilic Disorders and Syndromes
- Homelessness and Social Issues
- Medicinal Plant Pharmacodynamics Research
- Microbial Metabolism and Applications
- Endoplasmic Reticulum Stress and Disease
- Cannabis and Cannabinoid Research
- Atherosclerosis and Cardiovascular Diseases
Inserm
2014-2022
Biology of Infection
2020-2022
Université Paris Cité
2014-2022
Institut Pasteur
2020-2022
Paris Cardiovascular Research Center
2014-2021
Délégation Paris 5
2014-2018
Sorbonne Paris Cité
2014-2018
Délégation Paris 7
2017-2018
University of Maroua
2017
Laboratoire de Biophotonique et Pharmacologie
2015
A rapid and massive influx of inflammatory cells occurs into ischemic area after myocardial infarction (MI), resulting in local release cytokines growth factors. Yet, the mechanisms regulating their production are not fully explored. The extracellular vesicles (EVs) interstitial space curbs important biological functions, including inflammation, influences development cardiovascular diseases. To date, there is no evidence for situ cardiac EVs MI.The present study tested hypothesis that EV...
Significance Atherosclerotic plaques tend to develop preferentially in areas of the vasculature exposed low and disturbed shear stress (SS), but mechanisms are not fully understood. In this study, we demonstrate that inefficient autophagy contributes development atherosclerotic low-SS areas. Defective endothelial only curbs alignment with direction blood flow, also promotes an inflammatory, apoptotic, senescent phenotype. Furthermore, genetic inactivation a murine model atherosclerosis...
Arterial cardiovascular events are the leading cause of death in patients with JAK2V617F myeloproliferative neoplasms (MPNs). However, their mechanisms poorly understood. The high prevalence myocardial infarction without significant coronary stenosis or atherosclerosis MPNs suggests that vascular function is altered. consequences mutation on reactivity unknown. We observe here increased responses to vasoconstrictors arteries from Jak2V617F mice resulting a disturbed endothelial NO pathway...
Blood flowing in arteries generates shear forces at the surface of vascular endothelium that control its anti-atherogenic properties. However, due to architecture tree, these are heterogeneous and atherosclerotic plaques develop preferentially areas where is low or disturbed. Here we review our recent study showing elevated stimulate endothelial autophagic flux inactivating macroautophagy/autophagy pathway promotes a proinflammatory, prosenescent proapoptotic cell phenotype despite presence...
Endothelial senescence, characterized by an irreversible cell cycle arrest, oxidative stress, and downregulation of endothelial nitric oxide synthase (eNOS), has been shown to promote dysfunction leading the development age-related vascular disorders. This study assessed possibility that local angiotensin system promotes senescence in coronary artery cells also protective effect Crataegus extract WS1442, a quantified hawthorn extract. Serial passaging from P1 P4 (replicative senescence)...
Abstract Central nervous system infections are amongst the most severe 1,2 , yet mechanisms by which pathogens access brain remain poorly understood. The model microorganism Listeria monocytogenes (Lm) is a major foodborne pathogen that causes neurolisteriosis, one of deadliest central 3,4 . While immunosuppression well-established host risk factor for neurolisteriosis 3,5 little known regarding bacterial factors underlying Lm neuroinvasion. We have developed clinically-relevant experimental...
Abstract Book of: Frontiers in CardioVascular Biology 2016 Florence 8th - 10th July Bienniel Congress of the ESC Council on Basic Cardiovascular Science
Objective: Preferential development of atherosclerotic lesions in areas low shear stress is associated with increased endothelial inflammation, apoptosis and senescence. On the contrary, high are protected from plaque development, but mechanisms remain elusive. Autophagy a protective mechanism allowing recycling defective organelles proteins to maintain cellular homeostasis. Our aim was understand role autophagy athero-protective effects stress. Approach Results: We used parallel plate...
Atherosclerotic lesions develop in arterial areas exposed to low shear stress (SS) such as the inner curvature or bends of aorta, where endothelial cells (ECs) express a pro-inflammatory and pro-senescent phenotype. We previously demonstrated that defective autophagy, regulated by hemodynamic forces, favours an athero-prone Studies have stated stabilized microtubules (MTs), function various post-translational modifications, facilitate efficient fusion autophagosomes lysosomes, critical step...
Abstract Atherosclerotic lesions preferentially develop in arterial areas exposed to low shear stress, where endothelial cells express a pro-inflammatory, apoptotic, and senescent phenotype. Endothelial atheroprone stress present defective autophagic flux, which favors pro-inflammatory phenotype the formation of atherosclerotic lesions. We tested hypothesis that HDAC6 inhibition could restore adequate levels autophagy stress. found blocking activity, either by pharmacological (Tubastatin-A)...
Abstract Central nervous system infections are amongst the most severe, yet mechanisms by which pathogens access brain remain poorly understood. The model microorganism Listeria monocytogenes (Lm) is a major foodborne pathogen that causes neurolisteriosis, one of deadliest central infections. While immunosuppression well-established host risk factor for little known regarding bacterial factors underlying Lm neuroinvasion. We have developed clinically-relevant experimental using hypervirulent...