A5005946282- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Neuroendocrine Tumor Research Advances
- Lung Cancer Research Studies
- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Cancer Research and Treatments
- CNS Lymphoma Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Viral-associated cancers and disorders
- Cancer survivorship and care
- Childhood Cancer Survivors' Quality of Life
- Lung Cancer Treatments and Mutations
- Neutropenia and Cancer Infections
- Acute Lymphoblastic Leukemia research
- Polyomavirus and related diseases
- Vascular Tumors and Angiosarcomas
- Inflammatory Biomarkers in Disease Prognosis
- Cancer-related cognitive impairment studies
- Genomic variations and chromosomal abnormalities
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
Sana Klinikum
2007-2022
University Medical Center Freiburg
1994-2015
University of Lübeck
2014
Arzneimittelkommission der deutschen Ärzteschaft
2009
Sana Kliniken Duisburg
2007
Krankenhaus Nordwest
2006
University of Freiburg
1995-2001
St James's University Hospital
1998
BACKGROUND Fatigue is a common and often severe problem in cancer patients undergoing chemotherapy. The authors postulated that physical activity training can reduce the intensity of fatigue this group patients. METHODS A receiving high dose chemotherapy followed by autologous peripheral blood stem cell transplantation (training group; n = 27) an exercise program during hospitalization. was comprised biking on ergometer supine position following interval pattern for 30 minutes daily....
Abstract We used whole-genome and transcriptome sequencing to identify clinically actionable genomic alterations in young adults with pancreatic ductal adenocarcinoma (PDAC). Molecular characterization of 17 patients PDAC enrolled a precision oncology program revealed gene fusions amenable pharmacologic inhibition by small-molecule tyrosine kinase inhibitors all KRAS wild-type (KRASWT) tumors (4 17). These included recurrent NRG1 rearrangements predicted drive development through aberrant...
We conducted a phase I/II trial to assess the feasibility and activity of VIP-E chemotherapy in small-cell lung cancer. End-points were treatment-related morbidity mortality, response treatment. duration response, survival.Two cycles combination followed by granulocyte colony-stimulating factor (G-CSF) given at dose etoposide (500 mg/m2), ifosfamide (4000 cisplatin (50 epirubicin mg/m2) 100 consecutive patients with SCLC. Thirty (19 LD, 11 ED SCLC) proceeded VIC-E high-dose autologous...
Background: Immunity and inflammatory response affect the tumour microenvironment progression of malignancies. Metabolic parameters ratios peripheral blood correlate with outcome in cancer patients. There exist several established validated inflammation-based scores prognostic significances including Glasgow Prognostic Score (GPS). Methods: In this retrospective, multicentre study, we investigated capabilities baseline GPS patients multiple myeloma (MM) undergoing autologous stem cell...
BACKGROUND Fatigue is a common and often severe problem in cancer patients undergoing chemotherapy. The authors postulated that physical activity training can reduce the intensity of fatigue this group patients. METHODS A receiving high dose chemotherapy followed by autologous peripheral blood stem cell transplantation (training group; n = 27) an exercise program during hospitalization. was comprised biking on ergometer supine position following interval pattern for 30 minutes daily....
We conducted a phase I-II trial to assess the activity of standard-dose (SDC) and high-dose chemotherapy (HDC) with etoposide, ifosfamide, cis/carboplatin, epirubicin (VIP-E, VIC-E) in 107 patients limited-stage (LS, stage I-IIIB) extensive (ES, IV) non-small-cell lung cancer (NSCLC).Updated results previously published are presented.Response rates survival after VIP-E were comparable those other combination chemotherapies NSCLC. Treatment-related mortality (TRM) SDC was 3% LS-NSCLC, 8%...
Randomized studies proved the efficacy of new drugs for systemic treatment advanced gastric cancer in past 5 years. However, little is known about use firstline chemotherapy clinical practice patients with or metastatic adenocarcinoma esophagogastric junction (AEG) and stomach. We investigated temporal trends therapy factors influencing decisions these during a 4-year period.1058 (median age 67 years) AEG cancers undergoing were documented Therapiemonitor® 2006-2009. Therapiemonitor collects...
Abstract Background The composition of the tumor microenvironment (TME) is conditioned by immunity and inflammatory response. Nutritional inflammation-based risk scores have emerged as relevant predictors survival outcome across a variety hematological malignancies. Methods In this retrospective multicenter trial, we ascertained prognostic impact established nutritional [Glasgow Prognostic Score (GPS), C-reactive–protein/albumin ratio (CAR), neutrophil–lymphocyte (NLR), index (PNI), (PI)] in...