A5042455926- Spine and Intervertebral Disc Pathology
- Regulation of Appetite and Obesity
- Orthopedic Infections and Treatments
- Spinal Cord Injury Research
- Spinal Fractures and Fixation Techniques
- Diet and metabolism studies
- Angiogenesis and VEGF in Cancer
- Pain Mechanisms and Treatments
- Mesenchymal stem cell research
- Peripheral Artery Disease Management
- Tendon Structure and Treatment
- Infectious Diseases and Tuberculosis
- Spinal Dysraphism and Malformations
- Neuroendocrine regulation and behavior
- Neuroscience of respiration and sleep
- Sleep and Wakefulness Research
- Diabetic Foot Ulcer Assessment and Management
- Electrolyte and hormonal disorders
- Orthopaedic implants and arthroplasty
- Hypothalamic control of reproductive hormones
- Intracerebral and Subarachnoid Hemorrhage Research
- Ion Transport and Channel Regulation
- Pain Management and Treatment
- Neurotransmitter Receptor Influence on Behavior
- Scoliosis diagnosis and treatment
Kaohsiung Chang Gung Memorial Hospital
2016-2025
Chang Gung University
2016-2025
Cheng Shiu University
2022-2025
National Defense Medical Center
1971-2016
China Medical University Hospital
2016
China Medical University
2016
Syracuse University
1978-1980
Taipei Veterans General Hospital
1971
Study Design: A retrospective cohort study.Purpose: To evaluate whether using antibiotic-impregnated bone graft (AIBG) enhances infection control and shortens the postoperative course of pyogenic discitis vertebral osteomyelitis (PDVO).Overview Literature: Surgical treatment PDVO is indicated for neurological deficit, instability, unknown pathogen, or poorly controlled infection.The posterior-only approach effective but requires 4-6 weeks antibiotic postoperatively.We hypothesized that AIBG...
This study tested whether combined ceftriaxone and adipose-derived mesenchymal stem cells (ADMSCs) would defend the spinal cord against acute infection (ASI) in rodent. Adult-Male-SD rats were grouped into groups 1 (SC)/2 (ASI)/3 (ASI + from days 2 to 28 after ASI induction)/4 allogenic ADMSCs day for a total of 3 doses/3 consecutive intervals by intravenous injection)/5 ADMSC) tissues harvested 28. Circulatory levels TNF-α/IL-6 at 7 28, these two parameters fluid lowest group 1, highest 2,...
Background: This study tested the hypothesis that extracorporeal shockwave therapy (ECSWT) effectively rescues critical limb ischemia (CLI) in mice through upregulation of GPR120, which protects against inflammation and angiogenesis to restore blood flow ischemic area. Methods results: Compared with control, ECSWT-induced GPR120-mediated anti-inflammatory effects significantly suppressed expression inflammatory signaling biomarkers (TAK1/MAPK family/NF-κB/IL-1β/IL-6/TNF-α/MCP-1) HUVECs,...
We examined whether combined exogenous mitochondria (ExMito) and cellular prion protein overexpression (Ove-PrPC) in adipose-derived mesenchymal stem cell (Ove-PrPC ADMSCs) therapy is superior to a single for protecting the brain against intracranial hemorrhage (ICH) rats. In vitro, compared with control group, ExMito transfusion into recipient cells (i.e., N2a cells) significantly increased under hypoxic conditions (P < 0.001) augmented ρ0 proliferation cell-cycle activation 0.001). PrPC−OE...
This study assessed the adverse drug reactions (ADRs) associated with HDAC inhibitors using VigiAccess database maintained by World Health Organization (WHO). Furthermore, it compared ADR profiles of three different drugs to identify one lowest individualized risk for patients. Data on events Inhibitors was retrieved from WHO-VigiAccess 6 January 2025. We obtained data age, gender, reporting year, and continent. Descriptive related were calculated Excel 2021. In this study, we used software...
// Mel S. Lee 1, * , Fan-Yen 2, Yung-Lung Chen 3 Pei-Hsun Sung Hsin-Ju Chiang 4 Kuan-Hung 5 Tien-Hung Huang Yi-Ling John Y. 6, 7 Tsung-Cheng Yin 1 Hsueh-Wen Chang 8 Hon-Kan Yip 3, 9, 10, 11, 12 Department of Orthopedics, Kaohsiung Gung Memorial Hospital and University College Medicine, Kaohsiung, Taiwan 2 Division Thoracic Cardiovascular Surgery, Cardiology, Internal Obstetrics Gynecology, Anesthesiology, 6 Computer Science Engineering, National Sun Yat-Sen University, Healthcare...
Although low-energy shock wave (SW) is adopted to treat ischemic diseases because of its pro-angiogenic properties, the underlying mechanism remains unclear. This study aimed at testing whether SW-induced angiogenesis may be through endothelial vascular growth factor receptor 2 (VEGFR2) signaling and trafficking. Phosphorylation VEGFR2-Akt-eNOS axis production nitric oxide (NO) were determined in human umbilical vein cells (HUVECs) treated with SW. Carotid artery ob/ob mice was SW before...
Extracorporeal shock wave (ECSW) and adipose-derived mesenchymal stem cells (ADMSCs) have been recognized to capacities of anti-inflammation angiogenesis. We tested the hypothesis that ECSW ADMSC therapy could attenuate ischemia-reperfusion- (IR-) induced thigh injury (femoral artery tightened for 6 h then tightness was relieved) in rats. Adult male SD rats (n = 30) were divided into group 1 (sham-control), 2 (IR), 3 (IR + ECSW/120 impulses at 0.12 mJ/mm2 given h/24 h/72 after IR), 4...
This study tested the hypothesis that preactivated and disaggregated shape-changed platelet (PreD-SCP) therapy attenuates lung injury from acute respiratory distress syndrome (ARDS) induced by 100% oxygen inhalation complicated sepsis through peritoneal administration of 1.5 mg/kg lipopolysaccharide (LPS).Adult male Sprague-Dawley rats, weighing 325 to 350 g, were randomized into group 1 (normal controls [NC]), 2 (NC + PreD-SCP [3.0 × 10, intravenous administration]), 3 (ARDS-LPS), 4...
This study investigated the hypothesis that probiotics enhanced therapeutic effect of adipose-derived mesenchymal stem cells (ADMSCs) on alleviating neuropathic pain (NP) due to chronic constriction injury (CCI) mainly through regulating microbiota in rats. SD rats (n = 50) were categorized into group 1 (sham-control), 2 (NP), 3 (NP + (i.e., 1.5 billion C.F.U./day/rat, orally h after NP procedure, followed by QOD 30 times)), 4 ADMSCs (3.0 × 105 cells) CCI six times seven total, i.e., mimic a...
Abstract Traumatic spinal cord injury (SCI) is a highly destructive disease in human neurological functions. Adipose‐derived mesenchymal stem cells (ADMSCs) have tissue regenerations and anti‐inflammations, especially with prion protein overexpression (PrPc OE ). Therefore, this study tested whether PrPc ‐ADMSCs therapy offered benefits improving outcomes via regulating nod‐like‐receptor‐protein‐3 (NLRP3) inflammasome/DAMP signalling after acute SCI rats. Compared ADMSCs only, the...
OBJECTIVE Multiple rods are utilized in adult spinal deformity (ASD) surgery to increase construct stiffness. However, the impact of multiple on proximal junctional kyphosis (PJK) is not well established. This study aimed investigate PJK incidence ASD patients. METHODS patients from a prospective multicenter database with minimum follow-up 1 year were retrospectively reviewed. Clinical and radiographic data collected preoperatively, at 6 weeks postoperatively, months every subsequent...
Abstract This study tested the hypothesis that combined therapy with human umbilical cord‐derived mesenchymal stem cells (HUCDMSCs) and hyperbaric oxygen (HBO) was superior to either one on preserving neurological function reducing brain haemorrhagic volume (BHV) in rat after acute intracerebral haemorrhage (ICH) induced by intracranial injection of collagenase. Adult male SD rats (n = 30) were equally divided into group 1 (sham‐operated control), 2 (ICH), 3 (ICH +HUCDMSCs/1.2 × 10 6...
(1) This study tests hypothesis whether extracorporeal shock wave (ECSW) therapy effectively salvages mouse critical limb ischemia (CLI). In vitro result demonstrated that the angiogenesis parameters (i.e., tubular length/cluster/network formation) and protein expressions of EGFR/VEGFR2/RAS/c-Raf/MEK/ERK/VEGF/p-PI3K/p-Akt/p-m-TOR were significantly progressively increased with stepwise augmentation ECSW energy (0.1/0.14/0.20 mJ/mm2/140 impulses). On other hand, they suppressed by...