A5033395667- Renal Diseases and Glomerulopathies
- Hormonal Regulation and Hypertension
- SARS-CoV-2 and COVID-19 Research
- Dialysis and Renal Disease Management
- Hepatitis B Virus Studies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Renal function and acid-base balance
- Hepatitis C virus research
- Electrolyte and hormonal disorders
- Renal and Vascular Pathologies
- Liver Disease Diagnosis and Treatment
- Head and Neck Cancer Studies
- Apelin-related biomedical research
- SARS-CoV-2 detection and testing
- Advanced Radiotherapy Techniques
- Viral gastroenteritis research and epidemiology
- Muscle and Compartmental Disorders
- Organ Transplantation Techniques and Outcomes
- Potassium and Related Disorders
- Innovation and Knowledge Management
- Pharmacological Effects and Toxicity Studies
- Adrenal and Paraganglionic Tumors
- Renal Transplantation Outcomes and Treatments
- Blood Pressure and Hypertension Studies
- Animal Virus Infections Studies
National Central University
2025
National Taiwan University
2014-2024
Institute of Cellular and Organismic Biology, Academia Sinica
2020-2024
Key Laboratory of Guangdong Province
2024
Chia-Yi Christian Hospital
2024
National Chung Hsing University
2023
National Taiwan University Hospital
2013-2023
Guangzhou University of Chinese Medicine
2022
National Tsing Hua University
2022
South China University of Technology
2021
The B.1.1.7 variant of SARS-CoV-2 first detected in the UK harbors amino-acid substitutions and deletions spike protein that potentially enhance host angiotensin conversion enzyme 2 (ACE2) receptor binding viral immune evasion. Here we report cryo-EM structures apo ACE2-bound forms. form showed one or two receptor-binding domains (RBDs) open conformation, without populating fully closed state. All three RBDs were engaged ACE2 binding. B.1.1.7-specific A570D mutation introduces a molecular...
Electromagnetic energy harvesting holds a promising future for energizing low power electronic devices in wireless communication circuits.This article presents an RF system that can harvest from the ambient surroundings at downlink radio frequency range of GSM-900 band.The is aimed to provide alternative source devices.The design consists three modules: single wideband 377 Ω E-shaped patch antenna, pi matching network and 7-stage voltage doubler circuit.These modules were fabricated on...
With the continuous emergence of new SARS-CoV-2 variants that feature increased transmission and immune escape, there is an urgent demand for a better vaccine design will provide broader neutralizing efficacy.We report mRNA-based using engineered "hybrid" receptor binding domain (RBD) contains all 16 point-mutations shown in currently prevailing Omicron Delta variants.A booster dose hybrid mice previously immunized with wild-type RBD induced high titers broadly antibodies against tested...
An efficient depth image based rendering with edge dependent filter and interpolation is proposed. The proposed method can solve the hole-filling problem in DIBR system efficiently high quality. PSNR of better than previous work by 6 dB subjective view shows quality better. In addition to that, number instruction cycles 3.7 percent compared
Abstract The emerging SARS-CoV-2 variants of concern (VOC) harbor mutations associated with increasing transmission and immune escape, hence undermine the effectiveness current COVID-19 vaccines. In late November 2021, Omicron (B.1.1.529) variant was identified in South Africa rapidly spread across globe. It shown to exhibit significant resistance neutralization by serum not only from convalescent patients, but also individuals receiving currently used vaccines multiple booster shots....
This study evaluated the associations between economic, social, psychological factors, and health-related quality of life hemodialysis patients. Cross-sectional design was used. End-stage renal disease patients who had received maintenance for more than 2 months at 14 centers in northern Taiwan were invited to participate. Demographic, psychosocial data collected. Depression assessed by Beck Inventory. Health-related measured Medical Outcomes Study Short-Form 36. Multivariable linear...
Single-donor or pooled platelet lysates (PL) can substitute for fetal bovine serum (FBS) mesenchymal stromal cell (MSC) expansion. However, clinical applications of MSCs, the use virally inactivated PL would be desirable. Recently, we have developed a solvent/detergent (S/D)-treated human preparation (S/D-PL) rich in growth factors. The capacity to this MSC expansion needs evaluated.Platelet concentrates were treated by S/D (1% tri-n-butyl phosphate and 1% Triton X-45), extracted oil,...
To establish prevalence of some renal abnormalities in schoolchildren, an epidemiologic study 132 686 including 69 903 boys and 62 783 girls, was conducted from March 1987 to May 1988 the city Taipei. At health station each school, students were screened quickly by a physician with portable real-time ultrasound equipment. When abnormality detected or suspected, examinee referred Taipei Municipal Women Children's Hospital for further investigation. Radiologic urologic procedures then...
In this study, a novel, highly efficient, environment friendly, and low-cost nanocatalyst, denoted as Ni(x)@Co−N−C, was successfully developed by encapsulating Ni nanoparticles into N-doped porous carbon derived from ZIF-67. A variety of techniques including powder X-ray diffraction (XRD), nitrogen adsorption/desorption, scanning electron microscopy (SEM), transmission (TEM), photoelectron spectrometer (XPS) were used to characterize the prepared materials. The TEM images reveal that...
BACKGROUND: To determine the best cutoff values of aspartate aminotransferase (AST) and alanine amino-transferase (ALT) in detecting viral hepatitis C infection among patients continuous ambulatory peritoneal dialysis (CAPD). METHODS: 90 (44 male 46 female) CAPD 526 adult controls (266 male, 260 were enrolled. Serum AST ALT measured by an auto-analyser monthly. HBsAg was examined using a RIA method anti-HCV second-generation EIA method. The for obtained from ROC (receiver-operating...
The prevalence of sexual dysfunction among male haemodialysis patients is high. Sexual composed both physiological and psychological factors. However, the role depression still obscure.A multicentre cross-sectional study 411 was conducted to define determinants dysfunction. Mid-week pre-dialytic biochemical haematological parameters were obtained. All required complete three questionnaires by themselves: (i) International Index Erectile Function (IIEF, Chinese version); (ii) Beck Depression...
Forty-one out of 408 cases (or 10%) primary glomerular disease had diffuse fine granular to arc-like short linear mesangial deposits IgM by direct immunofluorescence. The deposition was accompanied C1q and/or C4 in the same locality 29 cases, C3 10, and trace amounts IgA 6. Properdin-factor B not detected. Fine electron dense low density were detected mesangium all 41 microscopy, usually as a discrete or pattern beneath basement membrane correlated well with immunofluorescence findings. An...
In2O3 is of particular interest as a wide-gap transparent semiconductor oxide, in which the shallow donor defect oxygen vacancy plays an important role electronic properties. Herein, we focus on with various concentrations In2O3, where distribution found to be crucial structural stabilities. For specific supercell, formation energies oxygen-vacancy pairs remarkably depend distance between two vacancies, can used determine nonstoichiometric structure. Interestingly, when vacancies share same...
Abstract: A multicenter collaborative study was performed to investigate the prevalence of abnormal blood contents 6 trace metals, copper (Cu), zinc (Zn), aluminum (Al), lead (Pb), cadmium (Cd), and mercury (Hg), in hemodialysis (HD) patients analyze their relationship with medications, such as CaCO 3 , Ca acetate, Al containing phosphate‐binding agents, 1,25‐dihydroxy vitD 1‐hydroxy erythropoietin (EPO), well hematocrit level, by chi‐square statistics. From medical centers Taiwan, we...
Protoapigenone, isolated from the native fern plant Thelypteris torresiana, has anticancer activity against some cancer cells. However, toxicological mechanism for protoapigenone is still unknown. Here, we investigated effect of on human lung cell lines. The comet assay showed that DNA damage induced by dose-dependent. Trypan blue exclusion killing both time and dose dependent. IC(50) 12, 24, 48 h in H1299 cells 6.11, 2.74, 1.49 microM, respectively. Flow cytometry cycle perturbation such as...
Our aim was to investigate the prognostic significance of tumor-infiltrating lymphocytes (TILs) in operable tongue cancer patients.The presence CD3+, CD4+, CD8+, and forkhead box protein P3-positive (FOXP3+) TILs tumor tissues obtained from 93 patients during surgery examined using immunohistochemistry.The 3-year overall survival (OS) with a low CD8/FOXP3 ratio significantly lower than that high (63.8% vs. 87.3%, p = 0.001). Patients FOXP3 had regional recurrence-free (RRFS) did (49.3%...
Abstract Background Sequential infections with SARS-CoV-2 variants such as Alpha, Delta, Omicron and its sublineages may cause high morbidity, so it is necessary to develop vaccines that can protect against both wild-type (WT) virus variants. Mutations in SARS-CoV-2’s spike protein easily alter viral transmission vaccination effectiveness. Methods In this study, we designed full-length mRNAs for WT, BA.5 integrated each into monovalent or bivalent mRNA-lipid nanoparticle vaccines. A...