A5091668911- Chemical Synthesis and Reactions
- Organoboron and organosilicon chemistry
- Fluorine in Organic Chemistry
- Boron Compounds in Chemistry
- Cancer therapeutics and mechanisms
- Chemical Synthesis and Analysis
- Traditional and Medicinal Uses of Annonaceae
- Estrogen and related hormone effects
- Synthetic Organic Chemistry Methods
- Sesquiterpenes and Asteraceae Studies
- Chemical synthesis and alkaloids
- Chemical Reactions and Mechanisms
- Bioactive Compounds and Antitumor Agents
- Cyclopropane Reaction Mechanisms
- Synthesis of Organic Compounds
- Angiogenesis and VEGF in Cancer
- Synthesis and Reactions of Organic Compounds
- Phytochemical compounds biological activities
- Radical Photochemical Reactions
- Glycosylation and Glycoproteins Research
- Steroid Chemistry and Biochemistry
- Chemical Synthesis and Characterization
- Synthesis of β-Lactam Compounds
- Axon Guidance and Neuronal Signaling
- Synthesis and characterization of novel inorganic/organometallic compounds
University of Szeged
2020-2024
University of Duhok
2024
Novel 13α-estrone derivatives have been synthesized via direct arylation of the phenolic hydroxy function. Chan-Lam couplings arylboronic acids with as a nucleophilic partner were carried out under copper catalysis. The antiproliferative activities newly diaryl ethers against panel human cancer cell lines (A2780, MCF-7, MDA-MB 231, HeLa, SiHa) investigated by means MTT assays. quinoline derivative displayed substantial activity MCF-7 and HeLa low micromolar IC50 values. Disturbance tubulin...
Monoterpene and 5-methylcoumarin- or 5-methylchromone-coupled meroterpenoids occurring mainly in the Asteraceae species proved to have high potency against protozoans, worms, various tumor cells, which make them interesting targets for searching new bioactive compounds. The African plant
Cervical carcinoma is one of the most frequent malignant gynecological cancers in women reproductive age. Because poor tolerability currently available chemotherapeutic agents, efforts have been focused on developing innovative molecules, including steroids, that exert antineoplastic effects with a better safety profile. In addition to their endocrine properties, certain estrogens exhibit additional biological activities, such as antiangiogenic and anticancer effects. Based previous studies,...
Thirteen undescribed monoterpene-fused 5-methylcoumarins, named centrapalus coumarins A–M, were isolated from the aerial parts of Centrapalus pauciflorus together with seven known compounds. The structures established by extensive spectroscopic analyses, including 1D NMR, 2D and HR-ESI-MS experiments. compounds represent a wide range chemical diversity depending on connection head-to-tail coupled diisoprene unit. A–H I–L are based 6–6–6- 6–6-7-membered tricyclic ring systems, respectively. D...
Five unusual meroterpenoids based on new carbon skeletons, pauciflorins A–E (1–5), were isolated by multistep chromatographic separations of a methanol extract the aerial parts Centrapalus pauciflorus. Compounds 1–3 are derived connection 2-nor-chromone and monoterpene unit, whereas 4 5 dihydrochromone–monoterpene adducts with rarely occurring orthoester functionality. The structures solved using 1D 2D NMR, HRESIMS, single-crystal X-ray diffraction. Pauciflorins evaluated for...
Eight previously undescribed chromones, named pauciflorins F-M and two 5-methyl-2,4-chromadione derivatives as N O, were isolated from the methanol extract of leaves Centrapalus pauciflorus (Willd.) H.Rob. together with known (+)-spiro-ethuliacoumarin. The structures determined via extensive spectroscopic analyses, including HRESIMS, 1D NMR (1H, 13C JMOD), 2D (HSQC, HMBC, 1H-1H COSY, NOESY) experiments. Through an MTT assay, seven compounds tested for their antiproliferative properties...
Background Colorectal cancer (CRC) is the third most frequently diagnosed globally, with a high incidence of morbidity and mortality. Early diagnosis CRC crucial for determining appropriate treatment regimens, thereby prolonging overall survival rates improving prognostic outcomes. Objectives This study aimed to investigate expression profiles specific proteins in lymph nodes (LNs) patients, including integrin-linked kinase (ILK), vascular endothelial growth factor A (VEGFA), ephrin type-A...