A5052503244- Bioactive Natural Diterpenoids Research
- Biological Activity of Diterpenoids and Biflavonoids
- Traditional and Medicinal Uses of Annonaceae
- Sesquiterpenes and Asteraceae Studies
- Essential Oils and Antimicrobial Activity
- Plant biochemistry and biosynthesis
- Insect and Arachnid Ecology and Behavior
- Plant Pathogens and Fungal Diseases
- Synthetic Organic Chemistry Methods
- Insect and Pesticide Research
- Natural product bioactivities and synthesis
- Chemical synthesis and alkaloids
- Marine Sponges and Natural Products
- Phytochemistry and Biological Activities
- Forest Insect Ecology and Management
- Sensory Analysis and Statistical Methods
- Phytochemical compounds biological activities
- Free Radicals and Antioxidants
- Coleoptera Taxonomy and Distribution
- Plant Surface Properties and Treatments
- Hydrocarbon exploration and reservoir analysis
- Plant chemical constituents analysis
- Bee Products Chemical Analysis
- Subterranean biodiversity and taxonomy
- Plant and animal studies
University of Belgrade
2015-2025
University of Szeged
2023-2024
University of Belgrade – Faculty of Chemistry
2015-2022
Tetradenia riparia (Hochstetter) Codd belongs to the Lamiaceae family and it was introduced in Brazil as an exotic ornamental plant. A previous study showed its antimicrobial, acaricidal analgesic activities. Two compounds were isolated from essential oil of T. leaves identified 9β,13β-epoxy-7-abietene (1), a new one, 6,7-dehydroroyleanone (2), already reported for another The structure these determined by spectroscopic analysis comparison with literature data. cytotoxic activities 1 2...
Five previously undescribed tigliane diterpenes (1–4 and 7), along with three known tiglianes (5, 6, 8) were isolated from the root extract of Euphorbia nicaeensis using chromatographic techniques. The structures compounds determined spectroscopic tested for anti-HIV activity against HIV-1 NL4.3 HIV-2 ROD strains. Two derivatives (2 exhibited significant activity, IC50 values ranging 1.10 to 7.47 µM. This study highlights potential E. as a source novel bioactive derivatives, warranting...
Euphorbia nicaeensis All. belongs to the flowering plant family Euphorbiaceae. Our previous research has shown that latex of this species is a rich source jatrophane-type diterpenes. Due exceptional biological activities exhibited by these compounds, was extended root species. From roots E. nicaeensis, collected in Deliblato Sand (Serbia), diterpene from an extremely rare class lumiphorbol isolated for first time The structure compound determined spectroscopic techniques (1D and 2D NMR), as...
In this study, the antibacterial and cytotoxic activities of isolated compounds from roots Onosma visianii were investigated. By using different chromatographic techniques appropriate spectroscopic methods, seven naphthoquinones described: deoxyshikonin ( 1 ), isobutyrylshikonin 2 α-methylbutyrylshikonin 3 acetylshikonin 4 β-hydroxyisovalerylshikonin 5 5,8-O-dimethyl 6 ) 7 ). Among tested compounds, exhibited highest toward all bacterial species (MIC50 MIC90 for gram positive bacteria: 6.40...
Although all ground beetles have pygidial glands homologous in structure and function, there are many differences among species, often significant, terms of chemical composition the secretion morphology gland components. In this paper, two predatory beetle species genus Carabus, namely C. (Tomocarabus) convexus (Procrustes) coriaceus, were subjected to chemical, morphological histological study their glands' secretions. Altogether, three carboxylic acids isolated, reservoir other glandular...
Abstract Cuticular hydrocarbons (CHCs) in Drosophila melanogaster represent the basis of chemical communication being involved many important biological functions. The aim this study was to characterize composition and variation cuticular profiles five D. strains. These strains were reared for approximately 300 generations on diets: standard cornmeal medium substrates prepared with apple, banana, tomato, carrot. Differences quantity and/or quality CHCs assumed as a result activation...
Monoterpene and 5-methylcoumarin- or 5-methylchromone-coupled meroterpenoids occurring mainly in the Asteraceae species proved to have high potency against protozoans, worms, various tumor cells, which make them interesting targets for searching new bioactive compounds. The African plant
Five yeast strains Saccharomyces cerevisiae and bayanus (SB, Top Floral, 15, Aroma White, Red Fruit) two nutrients, diammonium phosphate Nutrifermarom, examined for their influence on young apricot brandies, with a special emphasis chemical, volatile sensory characteristics. Analysis major minor analysis of the brandy shows important difference between samples. Total scores brandies ranged 16.88 control sample to 18.35 produced SB strain diamonium as nutrient. All samples fulfilled EU...
Thirteen undescribed monoterpene-fused 5-methylcoumarins, named centrapalus coumarins A–M, were isolated from the aerial parts of Centrapalus pauciflorus together with seven known compounds. The structures established by extensive spectroscopic analyses, including 1D NMR, 2D and HR-ESI-MS experiments. compounds represent a wide range chemical diversity depending on connection head-to-tail coupled diisoprene unit. A–H I–L are based 6–6–6- 6–6-7-membered tricyclic ring systems, respectively. D...
Five unusual meroterpenoids based on new carbon skeletons, pauciflorins A–E (1–5), were isolated by multistep chromatographic separations of a methanol extract the aerial parts Centrapalus pauciflorus. Compounds 1–3 are derived connection 2-nor-chromone and monoterpene unit, whereas 4 5 dihydrochromone–monoterpene adducts with rarely occurring orthoester functionality. The structures solved using 1D 2D NMR, HRESIMS, single-crystal X-ray diffraction. Pauciflorins evaluated for...
Eight previously undescribed chromones, named pauciflorins F-M and two 5-methyl-2,4-chromadione derivatives as N O, were isolated from the methanol extract of leaves Centrapalus pauciflorus (Willd.) H.Rob. together with known (+)-spiro-ethuliacoumarin. The structures determined via extensive spectroscopic analyses, including HRESIMS, 1D NMR (1H, 13C JMOD), 2D (HSQC, HMBC, 1H-1H COSY, NOESY) experiments. Through an MTT assay, seven compounds tested for their antiproliferative properties...
In the previous study fifteen jatrophane diterpenes were isolated from Euphorbia nicaeensis latex. Fourteen of them have been shown to be potent P-glycoprotein (P-gp) inhibitor in two MDR cancer cells (NCI-H460/R and DLD1-TxR). The aim this was determine whether which can root plant, then examine their inhibition power on selected cell lines (NCI- -H460, DLD1, U87, NCI-H460/R, DLD1-TxR U87-TxR). Two previously undescribed E. collected Deliblato Sand (Serbia). structures compounds determined...
The phytochemical investigation of
The aim of this research was to verify the authenticity monofloral honeys from territory Republic Serbia on basis physicochemical parameters routinely measured in honey quality control using multivariate analysis. Seventeen samples (11 acacia and 6 sunflower honey) were analyzed. Physicochemical analysis included examination basic qualitative quantitative analyses phenolic compounds. In tested, a total 93 compounds tentatively identified, 19 them quantified. obtained data served as input for...
Two sets of structurally different jatrophanes (1-11 and 13-16), jatrophane 12, latex extract 2 Euphorbia species (17 18) were tested for in vitro protective effect against chromosome aberrations peripheral human lymphocytes using the cytokinesis-block micronucleus (CBMN) assay. Jatrophanes 1-6 minimal doses 1 µg/mL prominently decreased micronuclei (MN) frequency range 44.86% to 34.29% manifested considerable effect. From other set jatrophanes, 13 same dose notably MN by 31.05%, while...
In this study, three tetracyclic triterpenes: (3S,24S)-tirucall-7-ene-3,24,25-triol (1), (3S,24R)-tirucall-7-ene-3,24,25-triol (2) and inoterpene C (3), were isolated from the milkweed Euphorbia nicaeensis All. using dry-column flash silica gel chromatography semipreparative normal-phase HPLC. Their structures determined on basis of 1D 2D NMR spectra literature review. Although these compounds have previously been other plant species, is first time that they E. nicaeensis.
Euphorbia seguieriana ssp. Necker (ES) and cyparissias (EC) with a habitat in the Deliblato Sands were subject of this examination. The latexes these so far insufficiently investigated species genus are used traditional medicine for treatment wounds warts on skin. To determine their chemical composition, non-targeted screening latexes' chloroform extracts was performed using liquid chromatography coupled quadrupole time-of-flight mass spectrometry employing an electrospray ionization source...
The presence of n-alkanes, free alcohols and acids in leaf epicuticular wax extracts 22 samples 11 Euphorbia L. species belonging to the sections Paralias, Esula, Myrsiniteae Helioscopia, 10 which were never examined before, analyzed by gas chromatography (GC) chromatography/mass spectrometry (GC/MS), n-alkane C27 was detected as principal component waxes majority species, while most abundant alcohol C26. Three section Helioscopia characterized a predominance C28. Free acid (C16) major 21...
In this study we have reported the chemical composition of essential oils obtained from needles twelve Pinus taxa, belonging to subgenera (sections and Trifoliae) Strobus (sect. Quinquefoliae). Monoterpenes dominated over sesquiterpenes in most investigated taxa both subgenera, except representatives subsection Pinaster, subgenus Pinus. ?-Pinene was abundant terpene eight pines, but other dominant terpenes were found some - trans-caryophyllene, germacrene D, abietadiene ?-pinene. subsect....