A5055197053- Blood Pressure and Hypertension Studies
- Hormonal Regulation and Hypertension
- Heart Rate Variability and Autonomic Control
- Cardiovascular Health and Disease Prevention
- Cardiovascular Syncope and Autonomic Disorders
- Hemodynamic Monitoring and Therapy
- Renal function and acid-base balance
- Heart rate and cardiovascular health
- Cardiac Fibrosis and Remodeling
- Microbial metabolism and enzyme function
- Cardiovascular Function and Risk Factors
- Atrial Fibrillation Management and Outcomes
- Electrolyte and hormonal disorders
- Advanced Glycation End Products research
- Sepsis Diagnosis and Treatment
- Salivary Gland Disorders and Functions
- Mitochondrial Function and Pathology
- Cardiac pacing and defibrillation studies
- Cardiac Valve Diseases and Treatments
- Clinical practice guidelines implementation
- Cardiac and Coronary Surgery Techniques
- Acute Myocardial Infarction Research
- Cardiovascular Disease and Adiposity
- GDF15 and Related Biomarkers
- Connective Tissue Growth Factor Research
Third Xiangya Hospital
2019-2025
Central South University
2018-2025
Novem (Netherlands)
2024
Xiangya Hospital Central South University
2022
Guidelines recognized dual combination in initial antihypertensive therapy. Studies found that low-dose quadruple were superior to monotherapy. However, whether therapy is better than unknown. A randomized blinded crossover trial was conducted compare the efficacy and safety of antihypertensives (irbesartan 75 mg + metoprolol 23.75 amlodipine 2.5 indapamide 1.25 mg) with standard-dose 150 5 mg), both a single pill, treatment patients mild moderate hypertension. Patients randomly assigned 1:1...
This study aimed to investigate the association of vascular aging and left ventricular geometry in OSAHS-related hypertension population with good blood pressure control. A retrospective was conducted at Third Xiangya Hospital, collecting data from patients admitted between August 1, 2022, January 2024. Vascular parameters were collected, including ankle-brachial index (ABI), brachial-ankle pulse wave velocity (baPWV), carotid intima-media thickness (cIMT). Left mass (LVMI), relative wall...
Abstract Aims To evaluate the impact of Life's Essential 8 (LE8) on onset and progression trajectory cardiometabolic multimorbidity (CMM). Methods results This prospective study included 240,346 participants (median age, 57 years) free CMDs at baseline from UK Biobank. LE8 scores were divided into low, moderate, high cardiovascular health (CVH) groups baseline, with higher representing better CVH. CMM was defined as coexistence two or three diseases, including type 2 diabetes (T2D), ischemic...
We aimed to investigate the effect and mechanism of butyric acid on rat myocardial fibrosis (MF). 16S rRNA sequencing was used analyze gut microbiota characteristics Sham group MF group. HPLC applied measure in feces serum. In vitro, macrophages RMa-bm were stimulated with LPS IL-4, respectively, then butyrate added study influences M1/M2 polarization mitochondrial function macrophages. The fibroblasts co-cultured explore fibroblasts. addition, rats fed diet. Compared group, collagen...
A potential antifibrotic mechanism in pathological myocardial remodeling is the recruitment of beneficial functional subpopulations macrophages or transformation their phenotype. Macrophages are required to activate molecular cascades that regulate fibroblast behavior. Identifying mediators macrophage phenotype tantamount identifying button retards myocardium; however, relevant studies inadequate. Circulating renalase (RNLS) mainly renal origin, and cardiac myocytes also secrete it...
Abstract Background Hypertension is the most important modifiable cardiovascular risk factor. Epidemiological studies have shown benefits of lowering blood pressure (BP), but BP control a major challenge. Furthermore, there are significant sex differences in antihypertensive drug use and control. This study examined control, with aim reducing complications hypertension improving quality life. Methods The was performed our outpatient clinic, included 1529 patients without secondary or...
Abstract This study measured serum high mobility group box 1 (HMGB1) levels in patients with acute myocardial infarction (AMI) and/or heart failure (HF) and evaluated their relationship peripheral inflammatory biomarkers cardiac biomarkers, which have not been reported before. Of the patients, 55 had AMI without HF (AMI −HF ), 42 +HF 60 (HF −AMI ) compared 50 healthy controls. Blood samples were collected to assess HMGB1 blood test‐related (e.g., erythrocyte sedimentation rate [ESR], hs‐CRP,...
Abstract Background Combined antihypertensive therapy has obvious advantages over single drug therapy. Hypertension guidelines fully affirm the efficacy of dual combination in initial Recent studies have also pointed out that quadruple very low-dose drugs is superior to drugs. However, whether better than unknown. Methods/design A randomized double-blind crossover clinical trial will be conducted compare and safety antihypertensives (irbesartan 75 mg + metoprolol 23.75 amlodipine 2.5...
Abstract Background We are currently faced with an increasing burden of cardiovascular disease in China and the inadequacy application guidelines clinical practice. In past decade, has been strengthening healthcare system, but it still lacked a national performance measurement system appropriate quality improvement strategy. Therefore, order to improve implementation guideline recommendations practice, learnt from successful experience Get With The Guidelines project 2014. Under guidance...
Changes in left ventricular (LV) geometry are early manifestations of cardiac damage. The relationship between vascular aging and LV has been reported. However, newly diagnosed primary aldosteronism (PA), with more severe target organ damage than essential hypertension, the never described.We conducted a retrospective study among PA from 1 January 2017 to 30 September 2021 at Third Xiangya Hospital. data parameters were collected, including ankle-brachial index (ABI), brachial-ankle pulse...
To evaluate the accuracy and stability of arterial blood gas (ABG) results by comparison with venous measurements from routine tests, to compare performance two sampling syringes, pre-heparinized syringe (PHS) disposable (DABS), in ABG analysis.We retrospectively analyzed practical use PHS DABS collecting samples, involving 500 400 patients, respectively. For each patient, addition sample, a sample was also collected using collection tube (VBCT) used for tests. Accordingly, patients were...
Background and Objective: Guidelines recognized the dual combination in initial antihypertensive therapy. Studies demonstrated low-dose quadruple was superior to monotherapy. However, whether therapy is better than unknown. Methods: A randomized blinded crossover trial conducted compare efficacy safety of antihypertensives (irbesartan 75 mg + metoprolol 23·75 amlodipine 2·5 indapamide 1·25 mg) with standard-dose 150 5 treatment patients mild moderate hypertension. Patients were randomly...
It would be of great clinical value to find an indicator that can accurately evaluate the early-stage renal injury in primary hypertension. Previous findings have shown renalase not only plays important role hypertension but also closely correlates with kidney function. The purpose this study is investigate whether urinary could used as a predictive index damage patients Urinary albumin creatinine ratio (UACR) was divide subjects into two groups: no (NRD) group (UACR <30 mg/g) and (RD)...
Poor adherence to antihypertensive drugs is a major cause of unsatisfactory blood pressure control. Hypertension doctors play an integral role in improving medication hypertensive patients. Although most existing studies have recognized the status quo and influencing factors adherence, little attention has been paid hypertension doctors' awareness practice management. Therefore, this study, we aimed investigate This cross-sectional survey. A self-reported questionnaire was developed sent...
Background: The right ventricular (RV) function determines the prognosis of patients with pulmonary hypertension (PH). Metabolic disorders have been observed in RV myocardium PH. Activation β3 adrenoceptor improves cardiac and restores metabolic efficiency rodents heart failure; however, its role remains uncertain. Methods: Experimental PH was induced by monocrotaline (MCT) rats. Mirabegron, a selective agonist, given to MCT rats daily from day after injection at dose 10 mg/kg. In vivo...
BACKGROUND:Although various antihypertensive medications are available, some hypertensive patients have uncontrolled blood pressures, especially in the clinic. The aim of present study was to compare efficacies therapies our hypertension (HTN) clinic (monotherapy vs. combination therapy, fixed-dose (FDC) versus free equivalent (FEC), and diuretics non-diuretics. MATERIAL AND METHODS:In this retrospective study, at HTN Third Xiangya Hospital with primary were enrolled from June 2016 February...