A5102779810- Osteoarthritis Treatment and Mechanisms
- Natural product bioactivities and synthesis
- Inflammatory mediators and NSAID effects
- Pharmacological Effects of Natural Compounds
- Lipid Membrane Structure and Behavior
- Magnolia and Illicium research
- Toxic Organic Pollutants Impact
- Air Quality and Health Impacts
- Nanopore and Nanochannel Transport Studies
- ATP Synthase and ATPases Research
- Reproductive Biology and Fertility
- Bone Metabolism and Diseases
- Physical Activity and Health
- Essential Oils and Antimicrobial Activity
- Sesquiterpenes and Asteraceae Studies
- Macrophage Migration Inhibitory Factor
- Autophagy in Disease and Therapy
- Nosocomial Infections in ICU
- Connective Tissue Growth Factor Research
- Andrographolide Research and Applications
- Biological Activity of Diterpenoids and Biflavonoids
- Atherosclerosis and Cardiovascular Diseases
- Eicosanoids and Hypertension Pharmacology
- Phytochemistry and Biological Activities
- Advanced Fluorescence Microscopy Techniques
Wuhan University
2018-2025
Renmin Hospital of Wuhan University
2018-2025
China University of Geosciences
2023-2024
Jilin Medical University
2021
Fuyang Normal University
2018-2020
Wuhan Polytechnic University
2011
Luoyang Normal University
2007
Repairing articular cartilage defects is a great challenge due to the poor self-regenerative capability of cartilage. Hydrogel-based tissue engineering has been considered an effective strategy. In this study, inspired by mussel chemistry, catechol-modified chitosan (CS-C) hydrogel was prepared under catalysis horseradish peroxidase/hydrogen peroxide (HRP/H2O2) for defect repair in rat model. The rheological and swelling properties biodegradation behavior CS-C were investigated. Besides,...
Black carbon (BC) and heavy metal lead (Pb), as typical components of atmospheric PM2.5, have been shown to cause a variety adverse health effects. However, co-exposure BC Pb may induce pulmonary damage by aggravating toxicity via an unknown mechanism. This study aimed investigate the combined carboxylated black (c-BC) acetate (Pb) on human bronchial epithelial cells (BEAS-2B) at no-observed-adverse-effect level (NOAEL). Cells were exposed c-BC (6.25 μg/mL) (4 alone or their combination, was...
Although triple-negative breast cancer (TNBC) is the most refractory subtype among all cancers, it has been shown to have higher immune infiltration than other subtypes. We identified marine-derived small molecule MHO7, which acts as a potent immunogenic cell death (ICD) inducer through endoplasmic reticulum (ER) stress-C/EBP-homologous protein (CHOP) pathway, treat TNBC. MHO7 exerted cytostatic and cytotoxic effects on TNBC cells at an IC50 of 0.96-1.75 µM suppressed tumor growth with...
Abstract Background Pulsed electromagnetic field (PEMF) is a non-invasive treatment that utilizes fields to reduce inflammation and promote tissue repair. However, PEMFs’ anti-inflammatory effect on osteoarthritis (OA) the potential mechanism has not been fully elucidated. Methods Human chondrocytes (C28/I2) were stimulated with interleukin (IL)-1β or without of PEMF. CCK-8 assay Kit was used detect cell viability. RT-qPCR, ELISA, immunofluorescent staining western blot analyze relative...
Chondrocytes play an essential role in maintaining the structure and function of articular cartilage. Oxidative stress occurred chondrocytes accelerates cell senescence death, which contributes to development osteoarthritis (OA). Patchouli alcohol (PA), a kind sesquiterpene Pogostemon cablin, processes multiple bioactivities treatment many diseases. However, its effects antisenescence antioxidation on D-gal-induced aging mice model are still obscure. In this study, we found that PA could...
Moracin reduced the development of knee osteoarthritis in rats<italic>via</italic>its anti-inflammatory effect.
Osteosarcoma is a highly invasive primary malignancy of bone. Magnolol biologically active, which shows antitumor effects in variety cancer cell lines. However, it has not been elucidated magnolol's on human osteosarcoma cells (HOC). This study aimed to determine activity magnolol and illustrate the molecular mechanism HOC. showed significant inhibition effect growth MG-63 143B induced apoptosis cycle arrest at G0/G1. In cells, upregulated expressions proapoptosis proteins suppressed...
Osteoarthritis (OA), which is characterized by the destruction of articular cartilage and reactive hyperplasia bone, has been regarded as main cause disability worldwide. Joint inflammation accompanied release inflammatory factors matrix degrading enzymes involved in cartilage. Phillygenin (PHI), extracted from Forsythiae Fructus, a lignan compound. Previous researchers have found that PHI anti-oxidant anti-inflammatory effect on various diseases. However, whether osteoarthritis not...
Membrane tension is an important physical parameter of describing cellular homeostasis, and it widely used in the study processes involving membrane deformation reorganization, such as cell migration, spreading, division. Despite importance tension, direct measurement remains difficult. In this work, we developed a ratiometric fluorescent probe sensitive to by adjusting carbon chain structure based on polarity-sensitive fluorophores. The changes after cells were subjected or chemical...
Osteoarthritis (OA), a chronic disease featured by severe pain and persistent inflammation, significantly affects human health lowers the quality of life. Nuciferine (Nuf) is major alkaloids abundant in lotus leaf has various biological activities. In current study, we aimed to explored protective effect Nuf against OA its underlying mechanism vitro vivo. It was found that alleviated degradation extracellular matrix (ECM) under stimulation IL-1β inhibited production inflammation cytokines...
Sphingomyelinase (SMase), a hydrolase of sphingomyelin (SM) enriched in the outer leaflet plasma membrane mammalian cells, is closely associated with onset and development many diseases, but specific mechanisms SMase on cell structure, function, behavior are not yet fully understood due to complexity structure. Artificial cells minimal biological systems constructed from various molecular components designed mimic cellular processes, behaviors, structures, which excellent models for studying...
Osteoporosis is a common metabolic disease with high morbidity and mortality in the elderly, bringing heavy socioeconomic burden. Excess use of glucocorticoid main cause secondary Osteoporosis, there are limited therapies for glucocorticoid-induced osteoporosis (GIOP) treatment. In this study, we explored protective effect andrographolide (AGP) on dexamethasone (DEX)-induced dysfunction osteogenic inhibition vitro vivo. The results showed that AGP could alleviate DEX-induced cytotoxicity,...
Cell membrane stiffness is critical for cellular function, with cholesterol and sphingomyelin as pivot contributors. Current methods measuring are often invasive, ex situ, slow in process, prompting the need innovative techniques. Here, we present a fluorescence resonance energy transfer (FRET)-based protein sensor designed to address these challenges. The consists of two fluorescent units targeting cholesterol, connected by linker that responds proximity lipids. In rigid membranes, close...
In the crystal structure of title compound, C5H6NO+·ClO4−, intermolecular N—H⋯O, O—H⋯O and C—H⋯O hydrogen bonds between cations anions result in formation an infinite two-dimensional hydrogen-bonded supramolecular network.