A5101578849- Plant Molecular Biology Research
- Photosynthetic Processes and Mechanisms
- Plant Reproductive Biology
- Insect and Pesticide Research
- Chromosomal and Genetic Variations
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Insect Resistance and Genetics
- Plant and Fungal Interactions Research
- Genomics and Chromatin Dynamics
- RNA modifications and cancer
- Insect-Plant Interactions and Control
- Genetic Mapping and Diversity in Plants and Animals
- Genetic and phenotypic traits in livestock
- Genomics and Phylogenetic Studies
- Alcohol Consumption and Health Effects
- Click Chemistry and Applications
- Vitamin C and Antioxidants Research
- Immune cells in cancer
- Plant responses to elevated CO2
- Fungal Plant Pathogen Control
- Ginseng Biological Effects and Applications
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Chemical Synthesis and Analysis
- Renal function and acid-base balance
Chinese PLA General Hospital
2023-2024
Guangxi University of Chinese Medicine
2024
New York University
2021-2024
Jilin University
2018-2023
Nanjing Agricultural University
2023
Sun Yat-sen University
2017-2021
Shenyang Pharmaceutical University
2021
State Forestry and Grassland Administration
2020
Shandong Agricultural University
2020
Southwest University
2018-2019
N6-Methyladenosine (m6A) RNA methylation plays important roles during development in different species. However, knowledge of m6A monocots remains limited. In this study, we reported that OsFIP and OsMTA2 are the components methyltransferase complex rice uncovered a previously unknown function regulation plant sporogenesis. Importantly, is essential for male gametogenesis. Knocking out results early degeneration microspores at vacuolated pollen stage simultaneously causes abnormal meiosis...
Increasing grain yield is the most important object of crop breeding. Here, we report that elevated expression a conserved microRNA, OsmiR408, could positively regulate in rice (Oryza sativa) by increasing panicle branches and number. We further showed OsmiR408 regulates down-regulating its downstream target, OsUCL8, which an uclacyanin (UCL) gene phytocyanin family. The knock down or out OsUCL8 also increases yield, while overexpression results opposite phenotype. Spatial temporal analyses...
Abstract The cereal endosperm is a major factor determining seed size and shape. However, the molecular mechanisms of development are not fully understood. Long noncoding RNAs (lncRNAs) function in various biological processes. Here we show lncRNA, MISSEN , that plays an essential role early rice ( Oryza sativa ). parent-of-origin lncRNA expressed endosperm, negatively regulates development, leading to prominent dent bulge seed. Mechanistically, functions through hijacking helicase family...
The intine, the inner layer of pollen wall, is essential for normal development and germination pollen. However, composition developmental regulation intine in rice (Oryza sativa) remain largely unknown. Here, we identify a microRNA, OsmiR528, which regulates formation thus male fertility rice. mir528 knockout mutant aborted at late binucleate stage, significantly decreasing seed-setting rate. We further demonstrated that OsmiR528 affects by directly targeting uclacyanin gene OsUCL23...
Abstract Plant spermatogenesis is a complex process that directly affects crop breeding. A rapid change in gene abundance occurs at early meiosis prophase, when regulation selective. However, how these genes are regulated remains unknown. Here, we show rice reproductive phasiRNAs essential for the elimination of specific set RNAs during meiotic prophase I. These cleave target mRNAs regulatory manner such one phasiRNA can more than gene, and/or single be targeted by to efficiently silence...
Chronic obstructive pulmonary disease is a kind of chronic lung characterized by persistent air flow obstruction, which was the third leading cause death in China. The incidence COPD steadily and increasing has been globally sever disease. Accordingly, it urgently needed to explore how diagnose treat timely. This study aims find key genes as soon possible avoid processing analyze immune cell infiltration between early stage late stage. Two GEO datasets were merged merge data for analyses....
MicroRNAs (miRNAs) are small noncoding RNAs of ∼21 nt in length, which have regulatory roles many biological processes. In animals, proper functioning the circadian clock, is closely linked to fitness almost all living organisms, regulated by miRNAs. However, date, there been no reports miRNA regulation plant rhythm. Here, we report a natural variant miR397 that lengthens period and controls flowering time Arabidopsis (Arabidopsis thaliana). Highly conserved among angiosperms, has two...
Abstract BACKGROUND Cyflumetofen is an outstanding acaricide with a novel mode of action. Tetranychus cinnabarinus , important agricultural pest, notorious for developing resistance to most classes acaricides rapidly and results in enormous loss the economy. Our previous study had pointed out glutathione S‐transferase (GSTs) significantly contributed cyflumetofen‐resistance formation T. but more specific mechanism needed be further investigated. RESULTS The unstable was observed...
Abstract BACKGROUND Acaricide resistance is a serious problem in spider mites. Cyflumetofen new complex II inhibitor, whereas pyridaben acts at I and has been used for decades. Although cross‐resistance between cyflumetofen observed Tetranychus cinnabarinus , the specific mechanisms play have not yet investigated. RESULTS Investigation into identified five P450s, among which CYP389C16 was evaluated as most likely candidate conferring cross‐resistance. Knockdown of expression via RNA...
Pollen tube formation and growth are crucial steps that lead to seed production. Despite the importance of pollen growth, molecular mechanisms implicated in its spatial temporal control not fully known. In this study, we found an uclacyanin gene, OsUCL8, regulates intine deposition growth. The overexpression OsUCL8 led a striking irregularity pollination thus affected setting rate rice; many tubes appeared lose ability grow directly into style. Conversely, plants with knocked out...
Crop domestication, which gives rise to a number of desirable agronomic traits, represents typical model system plant evolution. Numerous genomic evidence has proven that noncoding RNAs such as microRNAs and phasiRNAs, well protein-coding genes, are selected during crop domestication. However, limited data shows long (lncRNAs) also involved in this biological process. In study, we performed strand-specific RNA sequencing cultivated rice Oryza sativa ssp. japonica O. indica, their wild...
Abstract MEIOSIS ARRESTED AT LEPTOTENE1 (MEL1), a rice (Oryza sativa) Argonaute (AGO) protein, has been reported to function specifically at premeiotic and meiotic stages of germ cell development is associated with novel class cell-specific small noncoding RNAs called phased (phasiRNAs). MEL1 accumulation temporally spatially regulated eliminated after meiosis. However, the metabolism turnover (i.e. homeostasis) during remains unknown. Here, we show that ubiquitinated subsequently degraded...
Abstract Cytochrome P450s (CYPs) play crucial roles in regulating plant growth, development, and stress tolerance. In this study, a perennial ryegrass ( Lolium perenne ) CYP gene, LpCYP72A15 , was identified as candidate gene osmotic tolerance based on cDNA library screening the background of yeast ∆ hog1 mutant. is localized plastids, its expression regulated by ABA treatment. Overexpressing significantly enhanced drought both Arabidopsis ryegrass. Under stress, transgenic showed...
Abstract Background Circulating metabolites (CM) play a pivotal role in our overall health, yet the current evidence concerning involvement of diverse CM benign prostatic hyperplasia (BPH) remains limited. Mendelian randomization (MR) offers promising avenue to explore potential impact on BPH. Methods In forward MR analysis, cohort 249 circulating was employed as exposures investigate their associations with BPH risk. Conversely, reverse an exposure assess its effects CM. Results The...
Minimal mimics of protein conformations provide rationally designed ligands to modulate function. The advantage minimal is that they can be chemically synthesized and coaxed proteolytically resistant; a key disadvantage minimization the binding epitope may associated with loss affinity specificity. Several approaches overcome this challenge envisioned, including deployment covalent warheads use nonnatural residues improve contacts surface. Herein, we describe our computational experimental...
DATA REPORT article Front. Genet., 24 February 2023Sec. Livestock Genomics Volume 14 - 2023 | https://doi.org/10.3389/fgene.2023.1038606
QSOX1 (quiescin-sulfhydryl oxidase 1) is involved in various processes, including apoptosis and the development of breast diseases. Here, we investigated effect on meat quality Simmental cattle by analyzing correlation between single nucleotide polymorphisms (SNPs), I2 204 C>T 378 C>T, certain traits. The effects triglyceride synthesis cell were further validated gene silencing or overexpression bovine fetal fibroblasts mammary epithelial cells. results showed that had significant...
Idiopathic pulmonary fibrosis (IPF) is a chronic disease of unknown etiology that lacks specific treatment. In IPF, macrophages play key regulatory role as major component the lung immune system, especially during inflammation and fibrosis. However, our understanding cellular heterogeneity molecular characterization in well their relevance clinical setting, relatively limited. this study, we analyzed in-depth single-cell transcriptome sequencing (scRNA-seq) data from tissues IPF patients,...