A5077413010- Advanced Glycation End Products research
- S100 Proteins and Annexins
- Immune Response and Inflammation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Inflammatory mediators and NSAID effects
- Immune cells in cancer
- vaccines and immunoinformatics approaches
- Diabetic Foot Ulcer Assessment and Management
- Genomics and Chromatin Dynamics
- Cancer Research and Treatments
- COVID-19 Clinical Research Studies
- Adipose Tissue and Metabolism
- RNA modifications and cancer
- SARS-CoV-2 and COVID-19 Research
- Muscle metabolism and nutrition
- Immunotherapy and Immune Responses
- Drug Transport and Resistance Mechanisms
- CRISPR and Genetic Engineering
- NF-κB Signaling Pathways
- Phagocytosis and Immune Regulation
- Cancer, Hypoxia, and Metabolism
University of Milano-Bicocca
2006
Tissue damage causes inflammation, by recruiting leukocytes and activating them to release proinflammatory mediators. We show that high-mobility group box 1 protein (HMGB1) orchestrates both processes switching among mutually exclusive redox states. Reduced cysteines make HMGB1 a chemoattractant, whereas disulfide bond makes it cytokine further cysteine oxidation sulfonates reactive oxygen species abrogates activities. leukocyte recruitment activation can be separated. A nonoxidizable mutant...
Abstract Vaccines have reduced severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) morbidity and mortality, yet emerging variants challenge their effectiveness. The prevailing approach to updating vaccines targets the antibody response, operating under presumption that it is primary defense mechanism following vaccination or infection. This perspective, however, can overlook role of T cells, particularly when levels are low absent. Here we show, through studies in mouse models...
Inflammation and tissue regeneration follow damage, but little is known about how these processes are coordinated. High Mobility Group Box 1 (HMGB1) a nuclear protein that, when released on injury, triggers inflammation. We previously showed that HMGB1 with reduced cysteines chemoattractant, whereas disulfide bond makes it proinflammatory cytokine. Here we report fully orchestrates muscle liver via CXCR4, its receptors TLR4/MD-2 RAGE (receptor for advanced glycation end products) not...
The redox-sensitive HMGB1 protein is a functional link between oxidative stress and persistent inflammation in muscular dystrophies.
We observed that binding sites for the ubiquitously expressed transcription factor CP2 were present in regulatory regions of multiple erythroid genes. In these regions, site was adjacent to a GATA-1. Using three such (from genes encoding factors GATA-1, EKLF, and p45 NF-E2), we demonstrated functional importance CP2/GATA-1 sites. particular, binds GATA-1 HS2 enhancer, generating ternary complex with DNA. Mutations consensus greatly impaired activity transient transfection assays K562 cells....
Injury can trigger an acute inflammatory response, even in the absence of concomitant infection."Sterile" inflammation is also associated with several types cancer.Two events are key for development sterile inflammation: recruitment leukocytes, especially neutrophils and monocytes, their activation to release proinflammatory cytokines.High-mobility group box 1 (HMGB1) a nuclear protein that signals tissue damage when released into extracellular medium, thus works as damage-associated...
Abstract Extracellular HMGB1 triggers inflammation following infection or injury, and supports tumorigenesis in inflammation-related malignancies. has several redox states: reduced recruits inflammatory cells to injured tissues forming a heterocomplex with CXCL12 signaling via its receptor CXCR4; disulfide-containing binds TLR4 promotes responses. Here we show that Diflunisal, an aspirin-like nonsteroidal anti-inflammatory drug (NSAID) been clinical use for decades, specifically inhibits...
Abstract Human malignant mesothelioma (MM) is an aggressive and highly lethal cancer that has been linked to asbestos erionite exposure. MM causes about 3,000 deaths per year in the US more than 100,000 worldwide. We previously found damage-associated molecular pattern (DAMP) high-mobility group box-1 protein (HMGB1) plays a critical role early carcinogenic events development by inducing tumor necrosis factor-alpha (TNF-α) secretion, potentiating survival of fiber-exposed primary human...