A5037516096- Advanced Glycation End Products research
- S100 Proteins and Annexins
- DNA Repair Mechanisms
- CRISPR and Genetic Engineering
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Molecular Biology Techniques and Applications
- Genomics and Chromatin Dynamics
- Inflammatory mediators and NSAID effects
- Pluripotent Stem Cells Research
IFOM
2020
San Raffaele University of Rome
2012
European Institute of Oncology
2011
Tabriz University of Medical Sciences
2011
Tissue damage causes inflammation, by recruiting leukocytes and activating them to release proinflammatory mediators. We show that high-mobility group box 1 protein (HMGB1) orchestrates both processes switching among mutually exclusive redox states. Reduced cysteines make HMGB1 a chemoattractant, whereas disulfide bond makes it cytokine further cysteine oxidation sulfonates reactive oxygen species abrogates activities. leukocyte recruitment activation can be separated. A nonoxidizable mutant...
Unrepaired DNA damage during embryonic development can be potentially inherited by a large population of cells. However, the quality control mechanisms that minimize contribution damaged cells to developing embryos remain poorly understood. Here, we uncovered an ATR- and CHK1-mediated transcriptional response replication stress (RS) in mouse stem (ESCs) induces genes expressed totipotent two-cell (2C) stage 2C-like This is mediated Dux, multicopy retrogene defining cleavage-specific program...
Today, with the tremendous potential of genomics and other recent advances in science, role science to improve reliable DNA extraction methods is more relevant than ever before. The ideal process for genomic demands high quantities pure, integral intact (gDNA) from sample minimal co-extraction inhibitors downstream processes. Here, we report development a very rapid, less-hazardous, throughput protocol extracting quality blood samples.Dried, clotted ethylene diamine tetra-acetic acid (EDTA)...
Injury can trigger an acute inflammatory response, even in the absence of concomitant infection."Sterile" inflammation is also associated with several types cancer.Two events are key for development sterile inflammation: recruitment leukocytes, especially neutrophils and monocytes, their activation to release proinflammatory cytokines.High-mobility group box 1 (HMGB1) a nuclear protein that signals tissue damage when released into extracellular medium, thus works as damage-associated...
Summary Unrepaired DNA damage during embryonic development can be potentially inherited by a large population of cells. However, the quality control mechanisms that minimize contribution damaged cells to developing embryos remain poorly understood. Here, we uncovered an ATR- and CHK1-mediated transcriptional response replication stress (RS) in ESCs induces genes expressed totipotent two-cell (2C) stage 2C-like This is mediated Dux, multicopy retrogene defining cleavage-specific program...