A5036923207- CRISPR and Genetic Engineering
- Pluripotent Stem Cells Research
- Microbial infections and disease research
- Plant Virus Research Studies
- Genetics and Neurodevelopmental Disorders
- Epigenetics and DNA Methylation
- Molecular Biology Techniques and Applications
- Animal Virus Infections Studies
- Plant Pathogens and Fungal Diseases
- DNA Repair Mechanisms
- Genomics and Phylogenetic Studies
- Diptera species taxonomy and behavior
- Williams Syndrome Research
- Congenital heart defects research
- Bee Products Chemical Analysis
- Plant Disease Resistance and Genetics
- Glioma Diagnosis and Treatment
- Effects of Vibration on Health
- Viral Infections and Vectors
- Influenza Virus Research Studies
- Herpesvirus Infections and Treatments
- Plant tissue culture and regeneration
- Reproductive Biology and Fertility
- Genomics and Chromatin Dynamics
- Healthcare and Venom Research
IFOM
2018-2020
European Institute of Oncology
2008-2018
Istituti di Ricovero e Cura a Carattere Scientifico
2014
Tabriz University of Medical Sciences
2008-2010
Unrepaired DNA damage during embryonic development can be potentially inherited by a large population of cells. However, the quality control mechanisms that minimize contribution damaged cells to developing embryos remain poorly understood. Here, we uncovered an ATR- and CHK1-mediated transcriptional response replication stress (RS) in mouse stem (ESCs) induces genes expressed totipotent two-cell (2C) stage 2C-like This is mediated Dux, multicopy retrogene defining cleavage-specific program...
The genetic base of fertility and ovulation rate in Moghani Ghezel sheep northwestern Iran northeastern Turkey is important because their fat-tailed meat carpet quality wool. genes encoding bone morphogenetic (BM) protein 15 growth differentiation (GD) factor 9, respectively BMP15 GDF9 have been shown to affect female productivity domesticated sheep. Recently, numerous investigations performed on a variety breeds determine the association between mutations these fertility. Thus, this study,...
Highlights•KMT2B is critical for neuronal transdifferentiation, whereas KMT2A dispensable•KMT2B responsible the activation of maturation gene program•KMT2B represses myocyte fate unleashed upon defective transdifferentiation•KMT2B dependence reveals candidate dystonia-causative genesSummaryTransdifferentiation fibroblasts into induced cells (iNs) by neuron-specific transcription factors Brn2, Myt1l, and Ascl1 a paradigmatic example inter-lineage conversion across epigenetically distant...
Abstract Malignant gliomas constitute one of the most significant areas unmet medical need, owing to invariable failure surgical eradication and their marked molecular heterogeneity. Accumulating evidence has revealed a critical contribution by Polycomb axis epigenetic repression. However, coherent understanding regulatory networks affected during gliomagenesis is still lacking. Here we integrate transcriptomic epigenomic analyses define Polycomb-dependent that promote gliomagenesis,...
Today, with the tremendous potential of genomics and other recent advances in science, role science to improve reliable DNA extraction methods is more relevant than ever before. The ideal process for genomic demands high quantities pure, integral intact (gDNA) from sample minimal co-extraction inhibitors downstream processes. Here, we report development a very rapid, less-hazardous, throughput protocol extracting quality blood samples.Dried, clotted ethylene diamine tetra-acetic acid (EDTA)...
Summary Unrepaired DNA damage during embryonic development can be potentially inherited by a large population of cells. However, the quality control mechanisms that minimize contribution damaged cells to developing embryos remain poorly understood. Here, we uncovered an ATR- and CHK1-mediated transcriptional response replication stress (RS) in ESCs induces genes expressed totipotent two-cell (2C) stage 2C-like This is mediated Dux, multicopy retrogene defining cleavage-specific program...
Recent report on existence of a stem region hemagglutinin has arisen new hopes for vaccination influenza A as it consist conserve fusion peptide shared across several subtypes and can be targeted by human immune system. Given that traditional based live attenuated viruses often fails to surpass such viral infection, great deal attention been devoted develop safe yet efficient system A. We believe natural bioshuttle recruited spontaneous mass vaccination. Thus, here, we hypothesize...
Direct reprogramming of mesoderm-derived fibroblasts into induced neurons (iNs) by neuronal-specific transcription factors Brn2, Myt1l and Ascl1 is a paradigmatic example inter-lineage conversion across epigenetically distant cells. Despite tremendous progress on the transcriptional hierarchy underlying transdifferentiation, concomitant epigenome resetting its drivers remain elusive. Here we investigated role KMT2A KMT2B, two histone H3 lysine 4 methylases with cardinal roles in development,...