A5033017354- Bone Tissue Engineering Materials
- Phase Equilibria and Thermodynamics
- Lysosomal Storage Disorders Research
- Advanced Drug Delivery Systems
- Lipid Membrane Structure and Behavior
- Dental materials and restorations
- RNA Interference and Gene Delivery
- Carbohydrate Chemistry and Synthesis
- Advancements in Transdermal Drug Delivery
- Carbon dioxide utilization in catalysis
- Antimicrobial Peptides and Activities
- Bone Metabolism and Diseases
- Analytical Chemistry and Chromatography
- Graphene and Nanomaterials Applications
- CO2 Reduction Techniques and Catalysts
- Cellular transport and secretion
- Vitamin D Research Studies
- Advanced oxidation water treatment
- Wound Healing and Treatments
- biodegradable polymer synthesis and properties
- Crystallization and Solubility Studies
- Biomedical Research and Pathophysiology
- Polymer Foaming and Composites
- Enzyme Production and Characterization
- Adsorption, diffusion, and thermodynamic properties of materials
Institut de Ciència de Materials de Barcelona
2009-2021
Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine
2009-2021
Universitat de les Illes Balears
2014-2018
Health Research Institute of the Balearic Islands
2015-2018
Research Institute of Health Sciences
2012-2018
Hospital Infantil de México Federico Gómez
2018
Consejo Nacional de Investigaciones Científicas y Técnicas
2015-2017
Universidad Nacional de Córdoba
2015
Planta Piloto de Ingeniería Química
2015
Universitat Autònoma de Barcelona
2010-2013
Flavonoids are small polyphenolic molecules of natural origin with antioxidant, anti-inflammatory, and antibacterial properties. Here, a bioactive surface based on the covalent immobilization flavonoids taxifolin quercitrin titanium substrates is presented, using (3-aminopropyl)triethoxysilane (APTES) as coupling agent. FTIR XPS measurements confirm grafting to surfaces. Using 2-aminoethyl diphenylborinate (DPBA, flavonoid-specific dye), modified surfaces imaged by fluorescence microscopy....
The integration of therapeutic biomolecules, such as proteins and peptides, in nanovesicles is a widely used strategy to improve their stability efficacy. However, the translation these promising nanotherapeutics clinical tests still challenged by complexity involved preparation functional reproducibility, scalability, cost production. Here we introduce simple one-step methodology based on use CO2-expanded solvents prepare multifunctional nanovesicle-bioactive conjugates. We demonstrate high...
Hydroxyapatite nanoparticles (HAP-NP) are incorporated in oral care products such as toothpastes and mouthwashes to treat dental sensitivity or promote enamel remineralisation. Despite the good performance of HAP-NP this application, it is important ensure its safety for consumers. For that reason, Scientific Committee on Consumer Safety (SCCS) evaluated an ingredient, but issued opinion was not completely conclusive SCCS recommended additional tests should be performed. Here, we used a...
Abstract Many dental implants fail due to the infection and inflammation that walk hand in with poor healing soft tissue integration. Titanium surfaces were nanocoated quercitrin, a natural flavonoid, aim improve integration increase success. Streptococcus mutans attachment biofilm formation was analysed. Then, anti-inflammatory properties potential of quercitrin-nanocoated boost regeneration tested using human gingival fibroblasts. An inflammatory situation mimicked interleulin-1-beta. We...
Myo-inositol hexaphosphate, also called phytic acid or phytate (IP6), is a natural molecule abundant in vegetable seeds and legumes. Among other functions, IP6 inhibits bone resorption. It adsorbed on the surface of hydroxyapatite, inhibiting its dissolution decreasing progressive loss mass. We present here method to directly functionalize Ti surfaces covalently with IP6, without using cross-linker molecule, through reaction phosphate groups TiO2 layer substrates. The grafting consisted an...
Fabry disease is a lysosomal storage arising from deficiency of the enzyme α-galactosidase A (GLA). The results in an accumulation glycolipids, which over time, leads to cardiovascular, cerebrovascular, and renal disease, ultimately leading death fourth or fifth decade life. Currently, disorders are treated by replacement therapy (ERT) through direct administration missing patients. In view their advantages as drug delivery systems, liposomes increasingly being researched utilized...
Polyphenol-based coatings have several potential applications in medical devices, such as cardiovascular stents, contrast agents, drug delivery systems, or bone implants, due to the multiple bioactive functionalities of these compounds. In a previous study, we fabricated titanium surfaces functionalized with flavonoids through covalent chemistry, and observed their osteogenic, anti-inflammatory, antifibrotic properties vitro. this work, report fluorescence-based method for quantification...
In this study, the effect on osteoclast activity in vitro and vivo of titanium implants that were coated with quercitrin was evaluated. Titanium surfaces covalently flavonoid quercitrin. The osteoclastogenesis first tested RAW264.7 cells supplemented receptor activator nuclear factor kappa-B ligand (RANKL) to generate osteoclast-like by tartrate-resistant acid phosphatase (TRAP) inmunostaining after five days culture, analysis mRNA expression levels markers related bone resorption seven...
Fabry disease is a rare lysosomal storage disorder characterized by deficiency of α-galactosidase A (GLA), hydrolase. The enzyme replacement therapy administering naked GLA shows several drawbacks including poor biodistribution, limited efficacy, and relatively high immunogenicity in patients. An attractive strategy to overcome these problems the use nanocarriers for encapsulating enzyme. Nanoliposomes functionalized with RGD peptide have already emerged as good platform protect deliver...
Abstract A multitude of microparticles and nanoparticles is developed to improve the delivery different small drugs large biomolecules, which are subject several hindering biological barriers that limit their optimal biodistribution therapeutic effects. Here, a soft, reliable, scalable method based on compressed CO 2 reported for obtaining nanoconjugates recombinant human epidermal growth factor nanovesicles called quatsomes, where latter consists cholesterol cetyltrimethylammonium bromide....
Abstract MicroRNAs (miRNAs) are small non‐coding endogenous RNAs, which attracting a growing interest as therapeutic molecules due to their central role in major diseases. However, the transformation of these biomolecules into drugs is limited unstability bloodstream, caused by nucleases abundantly present blood, and poor capacity enter cells. The conjugation miRNAs nanoparticles (NPs) could be an effective strategy for clinical delivery. Herein, engineering non‐liposomal lipid nanovesicles,...
Phytosterols have been receiving increasing attention due to their demonstrated health benefits. Micronization of phytosterol particles is desirable enhance physiological efficacy. Utilization the environmentally friendly compressed fluid-based technology, called Depressurization an Expanded Liquid Organic Solution (DELOS) was investigated micronize a mixture. A new polymorph β-sitosterol, which more crystalline than native form, obtained from DELOS process regardless conditions. In...
The feasibility of the Depressurization an Expanded Liquid Organic Solution (DELOS) method to process different active pharmaceutical ingredients (APIs) as finely divided powders with narrow particle size distribution, high crystallinity degree, polymorphic purity, and free from residual solvent has been demonstrated. Cholesterol, acetylsalicylic acid (aspirin), naproxen, acetaminophen, ibuprofen were chosen model drugs. It demonstrated that supersaturation ratio attained during...
Microemulsions are extensively used in advanced material and chemical processing. However, considerable amounts of surfactant needed for their formulation, which is a drawback due to both economic ecological reasons. Here, we describe the nanostructuration recently discovered surfactant-free, carbon dioxide (CO2)-based microemulsion-like systems water/organic-solvent/CO2 pressurized ternary mixture. "Water-rich" nanodomains embedded into "water-depleted" matrix have been observed...
Selective mono or double carbonylations could be achieved by using CO2-expanded liquids in [2 + 2 1] carbonylative reactions of alkenes acetylenes with allyl bromides catalyzed Ni(I).
Flavonoids are small polyphenolic molecules, ubiquitously found in nature, with antioxidant, anti-inflammatory and antibacterial properties. Recently, we presented a bioactive surface based on the covalent grafting of flavonoids taxifolin quercitrin titanium substrates. The flavonoid-modified surfaces exhibited interesting biological effects vitro two human cell types: they stimulated differentiation mesenchymal stem cells from umbilical cord (hUC-MSCs) to osteoblasts, showed anti-fibrotic...