A5013616292- Cardiac Arrest and Resuscitation
- Respiratory Support and Mechanisms
- COVID-19 and healthcare impacts
- Airway Management and Intubation Techniques
- Climate variability and models
- Trauma and Emergency Care Studies
- Cryospheric studies and observations
- Minimally Invasive Surgical Techniques
- Meteorological Phenomena and Simulations
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Sepsis Diagnosis and Treatment
- Hydrology and Drought Analysis
- Blood transfusion and management
- Blood properties and coagulation
- Lightning and Electromagnetic Phenomena
- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Natural Language Processing Techniques
- Gastrointestinal Tumor Research and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Colorectal Cancer Surgical Treatments
- COVID-19 Clinical Research Studies
- Economic and Financial Impacts of Cancer
- Healthcare cost, quality, practices
- Abdominal Trauma and Injuries
Universität Innsbruck
2016-2025
Hella (Germany)
2024
University of Greenwich
2022-2023
Creative Commons
2023
University of Münster
2023
Paracelsus Medical University
2020
Biocrates Life Sciences (Austria)
2020
Critically ill coronavirus disease 2019 (COVID-19) patients present with a hypercoagulable state high rates of macrovascular and microvascular thrombosis, for which hypofibrinolysis might be an important contributing factor.We retrospectively analysed 20 critically COVID-19 at Innsbruck Medical University Hospital whose coagulation function was tested ClotPro® compared that 60 healthy individuals Augsburg Clinic. ClotPro is viscoelastic whole blood testing device. It includes the TPA test,...
To evaluate the wound complication rate in patients undergoing transumbilical single-incision laparoscopic (SIL) surgery.SIL surgery claims to be less invasive than conventional laparoscopy. Small SIL series have raised concerns toward a higher related incision.In 44-month period, 1145 consecutive procedures were included. The outcomes assessed according intention-to-treat analysis principle. All followed for minimum of 6 months postoperatively, and complications recorded as bleeding,...
Trauma-induced coagulopathy (TIC) substantially contributes to mortality in bleeding trauma patients.The aim of the study was administer fibrinogen concentrate prehospital setting improve blood clot stability patients or presumed bleed.A prospective, randomised, placebo-controlled, double-blinded, international clinical trial.This emergency care trial conducted 12 Helicopter Emergency Medical Services (HEMS) and Doctors' vehicles (NEF NAW) four centres Austria, Germany Czech Republic between...
FXII deficiency results in spontaneous prolongation of activated partial thromboplastin time (aPTT), which is widely used to monitor thromboprophylaxis. Misinterpretation spontaneously prolonged aPTT may result omission thromboembolic treatment or even unnecessary transfusion blood products. This retrospective analysis was performed calculate a threshold level resulting prolongation. 79 critically ill patients with were included. A correlation and ROC curve for predicted by created find the...
Incorrect estimation of extreme values daily precipitation can have severe consequences in hydrological and engineering applications. Recent advances the study shown that Metastatistical Extreme Value Distribution (MEV) is superior to Generalized (GEV) whenever length available record small compared average recurrence time. This paper provides a detailed examination relative performance MEV GEV for both point estimates spatial modeling. An analysis large number sample years return periods...
In this paper, we propose an innovative iterative approach to rule learning, specifically designed for (though not limited to) text-based data. Our method focuses on progressively expanding the vocabulary used in each iteration, resulting a significant reduction memory consumption. Additionally, introduce Value of Confidence, which quantifies reliability generated rules. By leveraging our ensures that only most robust and trustworthy rules are retained, thereby enhancing overall quality...
Abstract. Atmospheric environments favorable for lightning and convection are commonly represented by proxies or parameterizations based on expert knowledge such as convective available potential energy (CAPE), wind shear, charge separation, combinations thereof. Recent developments in the field of high-resolution reanalyses, accurate observations, machine learning (ML), explainable artificial intelligence (XAI) open possibilities identifying tailored without prior knowledge. This study...
To investigate whether a lower fraction of inspired oxygen (FiO2) during the early phase lung separation is able to improve overall oxygenation blood assessed by arterial partial pressure (PaO2)/FiO2 ratio, and its effect on collapse postoperative pulmonary complications (PPC). Prospective, nonblinded, randomized controlled trial. Single-center trial at university hospital. Patients scheduled for thoracic surgery requiring one-lung ventilation (OLV). Study participants received either low...
The influence of adrenaline during cardiopulmonary resuscitation (CPR) on the neurological outcome cardiac arrest survivors is unclear. As little known about pathophysiological effects cerebral oxygen delivery and metabolism we investigated its parameters oxygenation in a pig model CPR.Fourteen pigs were anesthetized, intubated instrumented. After 5 min CPR was started continued for 15 min. Animals randomized to receive bolus injections either or 30 μg/kg every after commencement...
Abstract Background Flow-controlled ventilation is a novel method which allows to individualize according dynamic lung mechanic limits based on direct tracheal pressure measurement at stable constant gas flow during inspiration and expiration. The aim of this porcine study was compare individualized flow-controlled (FCV) current guideline-conform pressure-controlled (PCV) in long-term ventilation. Methods Anesthetized pigs were ventilated with either FCV or PCV over period 10 h fixed FiO 2...
The effects of adrenaline on cerebral blood vessels during cardiopulmonary resuscitation (CPR) are not well understood. We developed an extracorporeal CPR model that maintains constant low systemic flow while allowing adrenaline-associated vasculature to be assessed at different mean arterial pressure (MAP) levels independently the flow.After eight minutes cardiac arrest, low-flow life support (ECLS) (30 ml/kg/min) was started in fourteen pigs. After ten minutes, continuous administration...
Multifactorial comparison of flow-controlled ventilation (FCV) to standard pressure-controlled (PCV) in terms oxygenation cardiac surgery patients after chest closure.Prospective, non-blinded, randomized, controlled trial.Operating theatre at an university hospital, Austria.Patients scheduled for elective, open, on-pump, surgery.Participants were randomized either individualized FCV (compliance guided end-expiratory and peak pressure setting) or control PCV setting tidal volume 6-8 ml/kg)...
Cost-utility analysis generally requires valid preference-based measures (PBMs) to assess the utility of patient health. While generic PBMs are widely used, disease-specific may capture additional aspects health relevant for certain populations. This study investigates construct and concurrent criterion validity cancer-specific European Organisation Research Treatment Cancer (EORTC) Quality Life Utility-Core 10 dimensions (QLU-C10D) in non-small-cell lung cancer patients. We retrospectively...
Transplantation activity during the first wave of coronavirus disease 2019 (COVID-19) pandemic was severely affected worldwide. This retrospective analysis aimed to assess impact COVID-19 on organ donations and transplantations in Eurotransplant region 12 mo pandemic. Specifically, we compared donor transplantation numbers both waves determine whether transplant systems adapted this new reality.All reported from March 1, 2015, February 28, 2021, were collected International Foundation...
BACKGROUND A continuous gas flow provided by flow-controlled ventilation (FCV) facilitates accurate dynamic compliance measurement and allows the clinician to individually optimise positive end-expiratory peak pressure settings accordingly. OBJECTIVE The aim of this study was compare efficiency exchange impact on haemodynamics between individualised FCV pressure-controlled (PCV) in a porcine model oleic acid-induced acute respiratory distress syndrome (ARDS). DESIGN Randomised controlled...
Scores can assess the severity and course of disease predict outcome in an objective manner. This information is needed for proper risk assessment stratification. Furthermore, scoring systems support optimal patient care, resource management are gaining importance terms artificial intelligence.This study evaluated compared prognostic ability various common pediatric (PRISM, PRISM III, IV, PIM, PIM2, PIM3, PELOD, PELOD 2) order to determine which most applicable score sepsis patients timing...
Abstract Objectives The Quality of Life (QoL) Utility measure, QLU-C10D, is derived the European Organisation for Research and Treatment Cancer (EORTC) QoL Questionnaire, QLQ-C30. Based on cancer-specific nature, QLU-C10D expected to be sensitive responsive in lung cancer patients. Methods This retrospective analysis used data from four multi-center trials. Clinical validity was assessed comparison a generic standard utility instrument, EuroQoL Group´s EQ-5D-3L. Utilities six country tariffs...
Flow-controlled ventilation (FCV) ensures a constant gas flow whereby precise determination of dynamic compliance is feasible. Accordingly, ventilator pressure settings can be adjusted to achieve the highest compliance. This setting will automatically adapt tidal volume functionally available lung as personalized approach. in contrast current settings, where fixed volumes according predicted body weight (PBW) are recommended. Aim this subgroup-analysis was determine whether applied differs...
Sepsis is associated with a deflection of inflammatory and coagulative parameters, since some clotting factors are known to be involved in the host's defense against infection inflammation. These parameters could play crucial role course sepsis used as prognostic markers critically ill children. A total 250 pediatric patients diagnosed were retrospectively analyzed identify routinely measured predictors for in-hospital mortality at peak level C-reactive protein. Those entered multivariate...
Tigecycline offers broad anti-bacterial coverage for critically ill patients with complicated infections. A described but less researched side effect is coagulopathy. The aim of this study was to test whether tigecycline interferes fibrinogen polymerization by peripheral interactions. To the unmetabolized tigecycline, plasma healthy volunteers were spiked increasing concentrations tigecycline. In a second experimental leg, immortalized human liver cells (HepG2) treated same an inhibitory...
Abstract Purpose Progressive loss (sarcopenia) and fatty infiltration of muscle mass (myosteatosis) are well-established risk factors for an adverse clinical outcome in obese patients. Data concerning non-obese sarcopenic patients oncologic surgery scarce heterogeneous. The aim this study was to determine the impact sarcopenia myosteatosis with cancer right colon on outcome. Methods This comprised 85 a BMI < 30 kg/m 2 , who underwent single center. Skeletal area (SMA), visceral fat (VFA),...
Fibrinogen supplementation is recommended for treatment of severe trauma hemorrhage. However, required dosages and aimed post-treatment fibrinogen levels remain a matter discussion. Within the published RETIC study, adult patients suffering trauma-induced coagulopathy were randomly assigned to receive concentrate (FC) as first-line (n = 50) or crossover rescue 20) therapy. Depending on bodyweight, single dose 3, 4, 5, 6 g FC was administered repeated if necessary (FibA10 < 9 mm). The...