A5014023833- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Esophageal Cancer Research and Treatment
- Atrial Fibrillation Management and Outcomes
- Gastric Cancer Management and Outcomes
- Venous Thromboembolism Diagnosis and Management
- Esophageal and GI Pathology
- Blood transfusion and management
- Platelet Disorders and Treatments
- Thermal Regulation in Medicine
- Metastasis and carcinoma case studies
- Sepsis Diagnosis and Treatment
- Blood properties and coagulation
- Adipokines, Inflammation, and Metabolic Diseases
- Toxin Mechanisms and Immunotoxins
- Blood Coagulation and Thrombosis Mechanisms
- High Altitude and Hypoxia
- Intracerebral and Subarachnoid Hemorrhage Research
- Clinical Reasoning and Diagnostic Skills
- Colorectal Cancer Treatments and Studies
- Maternal and fetal healthcare
- Climate Change and Health Impacts
- Vitamin K Research Studies
- Acute Myocardial Infarction Research
- Neonatal and Maternal Infections
- Bioactive Compounds and Antitumor Agents
Isala
2011-2024
Innsbruck Medical University
2013-2020
Universität Innsbruck
2016-2020
Paracelsus Medical University
2020
University of Amsterdam
1998
Slotervaartziekenhuis
1995
Radiofrequency ablation (RFA) is safe and effective for the eradication of neoplastic Barrett's esophagus; however, occasionally there minimal regression after initial circumferential balloon-based RFA (c-RFA). This study aimed to identify predictive factors a poor response 3 months c-RFA, relate percentage at final treatment outcome.We included consecutive patients from 14 centers who underwent c-RFA high grade dysplasia worst. Patient characteristics were registered prospectively. "Poor...
Summary Thromboelastometry point‐of‐care coagulation testing facilitates optimised management of bleeding. Previous thromboelastometry systems required the blood sample and liquid reagents to be pipetted in several manual steps by trained personnel. The ROTEM sigma analyser is a fully automated device. We aimed assess reference ranges new device compare results with those predecessor device, delta . took from healthy volunteers hyper‐ or hypocoagulable patients; samples served determine for...
Trauma-induced coagulopathy (TIC) substantially contributes to mortality in bleeding trauma patients.The aim of the study was administer fibrinogen concentrate prehospital setting improve blood clot stability patients or presumed bleed.A prospective, randomised, placebo-controlled, double-blinded, international clinical trial.This emergency care trial conducted 12 Helicopter Emergency Medical Services (HEMS) and Doctors' vehicles (NEF NAW) four centres Austria, Germany Czech Republic between...
FXII deficiency results in spontaneous prolongation of activated partial thromboplastin time (aPTT), which is widely used to monitor thromboprophylaxis. Misinterpretation spontaneously prolonged aPTT may result omission thromboembolic treatment or even unnecessary transfusion blood products. This retrospective analysis was performed calculate a threshold level resulting prolongation. 79 critically ill patients with were included. A correlation and ROC curve for predicted by created find the...
Endoscopic resection is the cornerstone of endoscopic treatment esophageal high grade dysplasia or early cancer. is, however, a technically demanding procedure, which requires training and expertise. The aim current study was to prospectively evaluate efficacy safety first 120 procedures neoplasia performed by six endoscopists (20 resections each) who were participating in an program.The program consisted four tri-monthly 1-day courses with lectures, live-demonstrations, hands-on on...
Hypothermia has notable effects on platelets, platelet function, fibrinogen, and coagulation factors. Common laboratory techniques cannot identify those effects, because blood samples are usually warmed to 37°C before analysis do not fully reflect the in vivo situation. Multiple aspects of pathophysiological changes humoral cellular remain obscure. This vitro experimental study aimed compare measurements thromboelastometry (TEM), multiple-electrode aggregometry (MEA) Real Time Live Confocal...
Objective . To determine the role of four ELISA D‐dimer assays in exclusion pulmonary embolism. Design Blinded comparison using angiography and/or lung scintigraphy as a reference method. Setting A secondary and tertiary referral centre. Patients methods Consecutive patients with suspected embolism underwent scintigraphy, followed by if non‐diagnostic result was obtained. Comorbid conditions resulting elevated plasma levels were defined priori Cut‐off for 100% sensitivity determined....
In major bleeding events, the new direct oral anticoagulants pose a great challenge for physicians. The aim of study was to test ex vivo reversal anticoagulant rivaroxaban with various non-specific agents: prothrombin complex concentrate (PCC), activated (aPCC), recombinant factor VII (rFVIIa), and fibrinogen (FI).Blood obtained from healthy volunteers patients treated rivaroxaban. Blood samples were spiked correlation between concentration coagulation tests. Patient blood concentrations...
Direct oral anticoagulants (DOACs) pose a great challenge for physicians in life-threatening bleeding events. The aim of this study was to test the efficacy reversing DOAC rivaroxaban using four-factor PCC (prothrombin complex concentrate), non-specific agent.Patients with events during treatment were included and administered 25 U kg-1 PCC. Blood samples collected immediately prior as well after at predefined time intervals. primary endpoint defined difference thrombin generation (TG)...
Background Sepsis remains a major problem in intensive care medicine. It is often accompanied by coagulopathies, leading to thrombotic occlusion of small vessels with subsequent organ damage and even fatal multi-organ failure. Prediction the clinical course outcome—especially heterogeneous group pediatric patients—is difficult. Antithrombin, as an endogenous anticoagulant enzyme anti-inflammatory properties, plays central role controling coagulation infections. We investigated relationship...
The current study aims to evaluate whether prophylactic anticoagulation using argatroban or an increased dose of unfractionated heparin (UFH) is effective in achieving the targeted activated partial thromboplastin time (aPTT) more than 45 s critically ill heparin-resistant (HR) patients. Patients were randomized either continue receiving UFH, be treated with argatroban. endpoints defined as aPTT target at 7 h and 24 h. This clinical trial was registered on clinicaltrials.gov (NCT01734252)...
Introduction: This experimental in vitro study aimed to identify and characterize hypothermia-associated coagulopathy compare changes mild severe hypothermia with the quantitative measurement of rotational thromboelastometry (ROTEM) multiple-electrode aggregometry (MULTIPLATE). Methods: Whole blood samples from 18 healthy volunteers were analyzed at target temperatures 37, 32, 24, 18, 13.7°C ROTEM (ExTEM, InTEM FibTEM) MULTIPLATE using arachidonic acid 0.5 mM (ASPI), thrombin...
Background and Aim: Although fibrinogen has been established as a key player in the process of coagulation, many questions about role under specific conditions remain. Confocal microscopic assessment clot formation, particular that plays this process, is commonly investigated using pre-labeled fibrinogen. This number drawbacks, primarily it impossible to stain fibrin networks after their formation. The aim present study an alternative for conveniently post-staining wide range...
<b>Background:</b> Endoscopic resection is the cornerstone of endoscopic management esophageal early neoplasia. However, a complex technique requiring knowledge and expertise. Our aims were to identify most important learning points in performing training setting provide information on how improve technique. <b>Methods: </b>Six gastroenterologists at centers with multidisciplinary expertise upper gastrointestinal oncology participated structured program, consisting four days lectures...
The failure of EGFR inhibitors in colorectal tumors with KRAS mutations requires the development alternative treatment strategies for this patient subgroup. Among hallmarks cancer disturbed immunosurveillance and immune evasion have become emerging targets therapy. Due to their pleiotropic functions immunomodulatory drugs (IMiDs) are interesting agents combination therapies solid tumors. However, possible contribution a way monitoring biological effects yet be revealed. In heavily pretreated...
SUMMARY Background Patients with bone marrow failure secondary to chemotherapy often develop thrombocytopenia and require platelet transfusion. Fibrinogen plays an important role in aggregation the establishment of primary haemostatic plug. Objectives To compare effects vivo transfusion on clot firmness thrombocytopenic patients vitro ‐performed fibrinogen concentrate substitution. Materials methods Thirty haematological malignancy admitted for were included. Haemostatic from ex addition at...
Background: Trauma-induced coagulopathy (TIC) substantially contributes to mortality in bleeding trauma patients. We evaluated the feasibility and efficacy of pre-hospital administration fibrinogen concentrate patients or presumed bleed. (FC; Clottafact®, LFB France).Methods: A prospective, randomised, placebo-controlled, double-blinded trial was conducted Austria, Germany Czech Republic. Adult aged ≥18 years with major a need for volume therapy were eligible enrolment. Patients randomised...
Background Sepsis is characterized by a pro-inflammatory and pro-coagulatory shift which can induce life-threatening complications. Close monitoring risk stratification of sepsis patients crucial for proper treatment consequently patient outcome. Therefore, this study focuses on the response patterns inflammatory coagulatory parameters used in clinical routines to estimate course sepsis. Methods A total 1,110 diagnosed with were retrospectively analyzed identify routine measured at peak...
Aims Barrett's esophagus (BE) with early neoplasia is an indication for endoscopic treatment. Patients non-dysplastic BE are typically enrolled in surveillance program to enable detection, and treatment, of related neoplasia. In contrast, a subset patients concurrently diagnosed Our goal was distinguish cases detected through programs (i.e. initial detection progression later time (metachronous neoplasia)) from where were simultaneously (synchronous neoplasia).