A5026629201- Ear Surgery and Otitis Media
- Tracheal and airway disorders
- Congenital Ear and Nasal Anomalies
- Pediatric health and respiratory diseases
- Education, Psychology, and Social Research
- Hearing, Cochlea, Tinnitus, Genetics
- Hearing Loss and Rehabilitation
- Indoor Air Quality and Microbial Exposure
- Head and Neck Anomalies
- Infection Control and Ventilation
- Ear and Head Tumors
- Vestibular and auditory disorders
- Salivary Gland Tumors Diagnosis and Treatment
- Nasal Surgery and Airway Studies
- Obstructive Sleep Apnea Research
- Sinusitis and nasal conditions
- Otolaryngology and Infectious Diseases
- Streptococcal Infections and Treatments
- Respiratory and Cough-Related Research
- Eosinophilic Esophagitis
- Hearing Impairment and Communication
- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- Child Nutrition and Feeding Issues
- linguistics and terminology studies
University Hospital Brno
2016-2025
Masaryk University
2016-2025
Ocní klinika
2020
Mylan (Switzerland)
2020
Abstract Objective Chronic otitis media (COM) is a common middle ear disease in children and young adults. Dysfunction of the Eustachian tube bacterial infection are main causes. This pilot study aimed to describe compare bacteriomes adults with serious forms COM, such as cholesteatoma retraction pocket (RP) tympanic membrane, healthy ears. Study Design Observational study. Setting Clinical practice tertiary center. From January 1, 2021 August 31, 2022. Patients aged 0 20 years. Methods In...
Ribofl avin transporter defi ciency (RTD) is rare dis ease characterized by progressive loss of cranial and somatic nerve function. Typically ptosis, bulbar syndrome, muscle weakness, auditory neuropathy are manifested. Without treatment, this leads to death caused respiratory failure, especially when it starts in childhood. In paper, we present two siblings with RTD demonstrate the necessity early dia gnosis ribofl substitution treatment. can prevent hearing increase chance for successful...
Abstract Purpose The study aimed to evaluate audiological benefits, quality of hearing and safety two Bonebridge generation: BCI601 BCI602 (MED-EL, Innsbruck, Austria) in children. Methods Twelve children were implanted: five seven comprising ten conductive loss, single sided deaf SSD subjects. Audiological outcomes tested sound field audiometry, functional gain, speech recognition threshold (SRT50), noise (SPRINT) localisation abilities. Subjective measures Speech, Spatial Qualities Hearing...
Summary The canonical Wnt pathway, dependent on β‐catenin‐controlled transcription, is the most explored known to drive malignant transformation of multiple cell types. Several reports have suggested that this pathway also participates in chronic lymphocytic leukaemia ( CLL ) pathogenesis. To get a better insight into role Wnt/β‐catenin we analysed detail expression overexpressed ligand, encoded by WNT 3 gene, well‐defined cohort 137 patients. Our analysis demonstrated (i) untreated patients...
BACKGROUND The indirect visualisation of the glottic area with a videolaryngoscope could improve intubation conditions which may possibly lead to higher success rate first attempt. OBJECTIVE Comparison videolaryngoscopy and direct laryngoscopy for elective airway management in paediatric patients. DESIGN Prospective randomised controlled trial. SETTINGS Operating room. PARTICIPANTS 535 patients undergoing anaesthesia tracheal intubation. 501 were included final analysis. INTERVENTIONS...
Human papillomavirus (HPV) causes juvenile-onset recurrent respiratory papillomatosis (JORRP). Although HPV is common in children, the prevalence of JORRP low. It likely that other factors contribute to pathogenesis JORRP, during either activation or reactivation a latent infection. There evidence laryngopharyngeal reflux (LPR) might be such risk factor for adult-onset papillomatosis. This study investigated if LPR also JORRP.Children with larynx required microlaryngoscopy at tertiary...
Respiratory distress syndrome caused by a secondary surfactant deficiency is one of the most common diagnoses requiring admission to Neonatal Intensive Care Unit. We illustrate case term female newborn without prenatal and peripartal risks. There had been significant signs respiratory 4 h after delivery. The condition gradually worsened point needing oscillatory ventilation. infectious non-infectious causes were excluded. Considering course illness, congenital was suspected. nevertheless no...
Indoor dust particles are an everyday source of human exposure to microorganisms and their inhalation may directly affect the microbiota respiratory tract. We aimed characterize changes in nasopharyngeal bacteriome after short-term indoor (workplace) environments.
Inflammatory bowel disease (IBD) is today a global disease, the incidence of which growing in pediatric population. This prospective study aims to decipher IBD and its trend population through 16 years South Moravian Region Czech Republic.We evaluated data concerning 358 patients with newly diagnosed at University Hospital Brno, gastroenterology center for entire (0-18 years) cares all (1,187,667 inhabitants).The encompassed 3,488,907 children during years. We 192 (53.6%) Crohn (CD), 123...
Background: Obstructive sleep apnea (OSA) activates several pathophysiological mechanisms which can lead to the development of vascular diseases. Endothelial dysfunction (ED) is an initial step in atherosclerosis. The association between ED and OSA has been described studies, even previously healthy subjects. High-density lipoproteins (HDL) were generally considered be atheroprotective, low-density lipoprotein (LDL) atherogenic component lipoproteins. However, recent findings suggest a...
The young population requires early rehabilitation of their hearing loss for normal cognitive, auditive hence social development. All which, in turn, may have an impact on quality life (QoL). This study aims to evaluate QoL between two different bone conduction (BC) devices: a noninvasive adhesive aid (Adhear [ADH]) vs. active transcutaneous implant (Bonebridge [BB]).
The Bonebridge (BB) was the first active transcutaneous implantation system for bone conduction. main indications are conductive or mixed hearing loss and single-sided deafness. Treacher-Collins syndrome (TCS) is a rare genetic disease that affects craniofacial development. disorder results in deformations of facial structure including ear malformations, especially microtia canal atresia. These patients suffer from loss. CT scans often show unfavorable temporal anatomy making placement an...
Primary hypomagnesemia with secondary hypocalcemia (HSH) is a rare genetic disorder. Dysfunctional transient receptor potential melastatin 6 causes impaired intestinal absorption of magnesium, leading to low serum levels accompanied by hypocalcemia. Typical signs at initial manifestation are generalized seizures, tetany, and/or muscle spasms.We present 5 w/o female manifesting tonic-clonic seizures. Laboratory tests detected severe and The molecular analysis revealed two novel mutations...
The aim of this study was to identify relationships in children between responses specific questions interest a clinical questionnaire concerning swallowing-related difficulties and pathological signs on videofluoroscopic swallowing (VFSS). A prospective data analysis made evaluated with disorder January 2018 April 2021 at tertiary care centre. Each child enrolled the underwent subjective evaluation (targeted questions) instrumental examination In total, 51 suffering from problems (32...
The incidence of difficult airway in paediatric patients is lower than that the adult population, and majority should be predictable.The primary aim this trial was to evaluate pediatric patients. secondary predict these patients.Paediatric undergoing elective surgery under general anaesthesia a tertiary university hospital were examined, panel prediction tests performed. We recorded incidence, risk factors for events associated with together sensitivity specificity prediction.We...
Salivary gland choristoma is an extremely rare middle ear pathology. We present the case of a 10-year-old girl with unilateral conductive hearing loss. Tympanotomy showed nonspecific mass, absence stapes, anomaly incus, and displaced facial nerve. It was not possible to remove mass completely. Histology confirmed salivary choristoma. The in this can be improved bone-anchored aid.
Background Retraction pocket (RP) of the tympanic membrane (TM) is a common pathology in children that can cause ossicular chain erosion, cholesteatoma formation, and potentially life-threatening complications cholesteatoma. This study assessed functional anatomical results cartilage grafting with severe RP TM. Methods was retrospective review 212 from tertiary referral center. Results We identified significant differences hearing results, indication criteria, location TM fixation between...
Sepsis is one of the most common causes death in patients admitted to intensive care units (ICUs). The development sepsis significantly influenced by genetic predisposition. In this study, we highlight a potential association between variant fat mass and obesity-associated (