Xin Wen

ORCID: 0000-0002-2932-8996
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About
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Research Areas
  • Advanced Battery Materials and Technologies
  • Advancements in Battery Materials
  • Advanced Battery Technologies Research
  • Antimicrobial agents and applications
  • Solid State Laser Technologies
  • Glass properties and applications
  • Laser-Plasma Interactions and Diagnostics
  • Chemical Synthesis and Analysis
  • Photonic Crystal and Fiber Optics
  • biodegradable polymer synthesis and properties
  • Bone Metabolism and Diseases
  • Graphene and Nanomaterials Applications
  • Fibroblast Growth Factor Research
  • Synthesis and Biological Evaluation
  • Adipose Tissue and Metabolism
  • Laser-induced spectroscopy and plasma
  • Dental materials and restorations
  • Monoclonal and Polyclonal Antibodies Research
  • Click Chemistry and Applications
  • Polymer Surface Interaction Studies
  • Catalytic C–H Functionalization Methods
  • Cancer-related molecular mechanisms research
  • Carbon dioxide utilization in catalysis
  • Luminescence Properties of Advanced Materials
  • Bone and Dental Protein Studies

Chinese Academy of Sciences
2019-2024

Beijing National Laboratory for Molecular Sciences
2024

Institute of Chemistry
2024

University of Chinese Academy of Sciences
2019-2024

Shandong University
2024

Shanghai Institute of Materia Medica
2020-2023

Zhejiang Sci-Tech University
2022

Institute of Soil Science
2022

Shandong Agricultural University
2021-2022

Henan University
2021-2022

Microplastics (MPs) can enter plants through the foliar pathway and are potential hazards to ecosystems human health. However, studies related molecular mechanisms underlying impact of exposure differently charged MPs leafy vegetables limited. Because surfaces in environment often charged, we explored uptake pathways, accumulation concentration MPs, physiological responses, lettuce foliarly exposed carrying positive (MP

10.1021/acs.est.2c06054 article EN Environmental Science & Technology 2022-11-10

Tm³⁺ doped barium gallo-germanate (BGG) glass has emerged as a promising 2.0 μm laser material offering excellent optical property. Unfortunately, low anti-crystallization ability and high OH⁻ content of the have hindered fabrication high-quality fibers. In this paper, La₂O₃ Y₂O₃ were added into BGG to enhance ability. Additionally, optimized Reaction Atmosphere Procedure (RAP) was utilized minimize content. Continuous single-mode (SM) fibers successfully obtained by rod-in-tube technique...

10.1364/oe.23.007722 article EN cc-by Optics Express 2015-03-16

Highly Tm(3+) doped optical fibers are urgently desirable for 2.0 μm compact single-frequency fiber laser and high-repetition-rate mode-locked laser. Here, we systematically investigated the parameters, energy transfer processes thermal properties of barium gallo-germanate (BGG) glasses. BGG glass single mode (SM) were fabricated by rod-in-tube technique. The doping concentration reaches 7.6 × 10(20) ions/cm(3), being reported highest level in SM fibers. Using ultra short (1.6 cm) as-drawn...

10.1038/srep20344 article EN cc-by Scientific Reports 2016-02-01

The development of polymer electrolytes with good ion transport capacity and high mechanical strength is a big challenge for solid electrolytes.

10.1039/d1ta07252h article EN Journal of Materials Chemistry A 2021-11-23

Aryl–heteroatom (C–X) bonds ubiquitously exist in organic, medicinal, and material chemistry, but a universal method to construct diverse C–X is lacking. Here we report our discovery of convenient efficient approach various using arylammonium salts as the substrate via an SNAr process. This strategy features mild reaction condition, no request transition metal catalyst, easy formation (C–S, C–Si, C–Sn, C–Ge, C–Se, C–N). The was successfully applied late-stage functionalization existing...

10.1016/j.isci.2019.04.038 article EN cc-by-nc-nd iScience 2019-05-01

Abstract Sulfur‐rich polymers synthesized by inverse vulcanization are promising cathodes for Li–S batteries and can suppress the shuttle effect to improve cycling properties of batteries. However, developing a sulfur‐rich copolymer with new chemical functionality enhance performance remains huge challenge. In this report, polymer cathode containing ionic liquid segments named poly(sulfur‐ co ‐1‐vinyl‐3‐allylimidazolium bromide) [poly(S‐ ‐DVIMBr)] was obtained S 8 DVIMBr used as first time....

10.1002/cssc.201903122 article EN ChemSusChem 2019-12-19

Since ibrutinib was approved by the FDA as an effective monotherapy for chronic lymphocytic leukemia (CLL) and multilymphoma, more FDA-approved covalent drugs are coming back into market. On this occasion, resurgence of interest in calls hit discovery techniques. However, limited numbers libraries prevent development area. Herein, we report design DNA-encoded library (DEL) its selection method inhibitors target proteins. These triazine-based DELs yielded potent compounds after against...

10.1021/acsmedchemlett.2c00127 article EN ACS Medicinal Chemistry Letters 2022-08-15

Bifaical solar cells hold great potential for achieving higher power output than conventional monofacial devices by harvesting irradiance from both their front and rear surfaces. However, almost all currently reported bifacial typically require a sputtered transparent conducting oxide electrode, which can damage the underlying layers due to plasma effects during deposition process. Here we report glue‐bonding strategy that uses high‐viscosity photovoltaic absorber slurry—in case of molten...

10.1002/ange.202505297 article EN Angewandte Chemie 2025-04-07

Solid polymer electrolytes (SPEs) have great potential to be used in high-safety lithium-ion batteries (LIBs). However, it is still a significant challenge for SPEs develop high ionic conductivity, mechanical strength, and good interior interfacial compatibility. In this work, ketone-based all-solid-state electrolyte (PAD) resulting from allyl acetoacetate (AAA), diacetone acrylamide (DAAM), poly(ethylene glycol) diacrylate (PEGDA) was prepared by UV-inducing photopolymerization. The...

10.1021/acsami.2c22228 article EN ACS Applied Materials & Interfaces 2023-03-29

DNA-encoded chemical library (DEL) has been extensively used for lead compound discovery decades in academia and industry. Incorporating an electrophile warhead into compounds recently permitted the of covalent ligands that selectively react with a particular cysteine residue. However, noncysteine residues remain underexplored as modification sites DELs. Herein, we report design utility tyrosine-targeting DELs 67 million compounds. Proteome-wide reactivity analysis tyrosine-reactive sulfonyl...

10.1021/jacs.3c08852 article EN Journal of the American Chemical Society 2023-10-19

To expand the chemical space of DNA-encoded library (DEL) technology, we have developed DNA-compatible cross-dehydrogenative coupling reaction between tetrahydroisoquinolines (THIQs) and a series nucleophiles such as nitromethane, terminal alkynes, so on. Both photo- metal-promoted conditions been successfully established for this C-1 derivation THIQs, exemplified by addition nitromethane. All these new transformations paved way divergent oriented synthesis THIQ-focused DELs.

10.1021/acs.orglett.0c01565 article EN Organic Letters 2020-07-09

The DNA-encoded library (DEL) is a powerful hit-generation tool in drug discovery. This study describes new DEL with privileged scaffold quinazolin-4(3H)-one developed by robust DNA-compatible multicomponent reaction and series of novel glutathione S-transferase (GST) inhibitors that were identified through affinity-mediated selection. A inhibitor 16 was subsequently verified an inhibitory potency value 1.55 ± 0.02 μM against SjGST 2.02 0.20 hGSTM2. Further optimization carried out via...

10.1021/acs.jmedchem.2c02129 article EN Journal of Medicinal Chemistry 2023-08-08

GaAs/AlGaAs quantum wells (QWs), selectively intermixed by SiO2 capping and rapid thermal annealing, have been characterized on a microscale using spatially resolved photoluminescence (PL) spectroscopy. From the evolution of PL spectra across boundary between unmixed regions, it was concluded that transition region is narrower than 1.5 μm excitation beam diameter. The magnitude intermixing also found to increase with thickness oxide. present QWs were be stable against subsequent treatment...

10.1063/1.101776 article EN Applied Physics Letters 1989-08-28

Solid polymer electrolytes (SPEs) have been one of the most promising candidates to replace nonaqueous liquid electrolyte for achieving high‐safety lithium‐ion batteries (LIBs). However, extremely low ionic transport capacities SPEs seriously hindered their applications in LIBs. Herein, a metal–organic framework (MOF) material MOF‐5 is applied enhancing electrochemical performances SPEs. Specifically, matrix first obtained via strategy random copolymerization trifluoroethyl methacrylate...

10.1002/ente.202000808 article EN Energy Technology 2020-11-26

Heavily Tm3+-doped barium gallo-germanate glass single-mode (SM) fibers were successfully drawn. A gain per unit length of 3.6 dB/cm at 1.95 µm was obtained. To the best our knowledge, this is highest reported for germanate SM fibers. single-frequency fiber laser operating has been built using a 1.5-cm-long active pumped by 1568 nm laser. The direct output power from ultracompact cavity 227 mW. results show that are highly promising high-power and applications.

10.7567/apex.11.032701 article EN Applied Physics Express 2018-01-29

It has been reported that multiwalled carbon nanotubes (MWCNTs) can reportedly positively affect growth and differentiation of bone-related cells therefore offer great potential in biomedical applications. To overcome negative immune responses limit their application, specific doping functionalization improve biocompatibility. Here, we demonstrated nitrogen-doped carboxylate-functionalized MWCNTs (N-MWCNTs) enhance bone remodeling both vitro vivo with excellent biocompatibility, via...

10.1021/acsami.1c05437 article EN ACS Applied Materials & Interfaces 2021-04-28

Porphyrins and their derivatives are a unique class of multifunctional modifiable π-conjugated heterocyclic organic molecules, which have been widely applied in the fields optoelectronic devices catalysis. However, application porphyrins polymer electrolytes for all-solid-state lithium-ion batteries (ASSLIBs) has rarely reported. Herein, porphyrin molecules modified by polyether chains used composite solid-state (CSPEs) first time. The introduction an electrolyte can not only promote...

10.1021/acsami.1c12086 article EN ACS Applied Materials & Interfaces 2021-10-12
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