A5100761905- Metabolism, Diabetes, and Cancer
- Adipose Tissue and Metabolism
- Ear Surgery and Otitis Media
- Regulation of Appetite and Obesity
- Diabetes Treatment and Management
- TGF-β signaling in diseases
- Pancreatic function and diabetes
- Pediatric health and respiratory diseases
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Thyroid Cancer Diagnosis and Treatment
- Natural product bioactivities and synthesis
- Peroxisome Proliferator-Activated Receptors
- T-cell and B-cell Immunology
- S100 Proteins and Annexins
- Adipokines, Inflammation, and Metabolic Diseases
- Hormonal Regulation and Hypertension
- Galectins and Cancer Biology
- Head and Neck Anomalies
- Endometriosis Research and Treatment
- Atrial Fibrillation Management and Outcomes
- Ion Transport and Channel Regulation
- Liver physiology and pathology
- Flavonoids in Medical Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
University of Ulsan
2010-2024
Ulsan College
2009-2024
Asan Medical Center
2024
Kyung Hee University Medical Center
2011-2022
Ulsan University Hospital
2011-2022
Kyung Hee University
2012-2015
Kyung Hee University East-West Neo Medical Center
2008-2013
Université de Lorraine
1997
Obesity, a condition characterized by increased fat content and altered secretion of adipokines, is risk factor for postmenopausal breast cancer. Visfatin has recently been established as novel adipokine that highly enriched in visceral fat. Here we report visfatin regulated proliferation MCF-7 human cancer cells. Exogenous administration recombinant cell DNA synthesis rate Furthermore, activated G1-S phase cycle progression upregulation cyclin D1 cdk2 expression. also the expression matrix...
In some instances, thyroid cancer may be diagnosed with histological examination after resection of putative or suspected benign nodule. these cases, completion thyroidectomy followed by radioiodine ablation is usually recommended to prevent recurrence. If small intrathyroidal found, not performed. Many patients have separate cancers in the contralateral lobe and cases essential even though primary tumour limited within thyroid.We analysed frequency malignant lesions assessed predictive...
Background: Anaplastic thyroid cancer (ATC) is one of the most lethal human malignancies.Docetaxel, a microtubule stabilizer, common chemotherapeutic agent used to treat various metastatic cancers.However, prolonged use results in side effects and drug resistance.Flavonoids, such as baicalein, are accepted dietary chemopreventive agents with many advantages, greater accessibility, affordability, lower toxicity, compared traditional chemotherapy agents.In this study, we evaluated whether...
The therapeutic use of nifedipine is limited by the rapidity onset its action and short biological half‐life. In order to produce a form devoid these disadvantages we made nanoparticles from three different polymers, poly‐ɛ‐caprolactone (PCL), polylactic glycolic acid (1:1) copolymers (PLAGA), Eudragit RL/RS (Eudragit). Nifedipine in polyethylene glycol 400 (PEG) solution was used as control. average diameters ranged 0.12 0.21 μm; encapsulation ratio 82% 88%. spontaneously hypertensive rats...
Triptolide is known to be involved in many cellular events, such as those related immunosuppressive and antitumor activity. We investigated whether triptolide mediates these effects through multiple mechanisms, including activation of cell cycle arrest caspase-dependent pathways, well by blocking nuclear factor-κB (NF-κB) potentiating the activities mitogen-activated protein kinase (MAPK) pathway, phorbol myristate acetate (PMA)-differentiated THP-1 cells. significantly inhibited...
Anaplastic thyroid cancer (ATC) is one of the most aggressive malignancies in humans, and its progression poorly controlled by existing therapeutic methods. Curcumin has been shown to suppress inflammation angiogenesis. In this study, we evaluated whether curcumin could augment docetaxel-induced apoptosis ATC cells. We also analyzed changes nuclear factor κB (NF-κB) cyclooxygenase-2 (COX-2) expression levels delineate possible mechanisms their combined action.ATC cells were cultured treated...
In the brain, aquaporin-1 (AQP-1), a water channel for high osmotic permeability, is mainly expressed in apical membrane of ventricular choroid plexus and regulates formation cerebrospinal fluid (CSF). Although physiology AQP-1 has been subject several publications, much less known about trans-acting factors involved control gene expression. Here we report that TTF-1, homeodomain-containing transcriptional regulator, coexpressed with rat brain enhances transcription by binding to conserved...
Background/Objective Visfatin, also known as nicotiamide phosphoribosyltransferase or pre-B cell colony enhancing factor, is a pro-inflammatory cytokine whose serum level increased in sepsis and cancer well obesity. Here we report role of visfatin the brain, to mediate sickness responses including anorexia, hyperthermia hypoactivity. Methodology Rats were intracerebroventricularly (ICV) injected with visfatin, changes food intake, body weight, temperature locomotor activity monitored....
The authors investigated the expression patterns of interleukin (IL)-lβ and tumor necrosis factor (TNF)-α, cytokines associated with peritoneal inflammatory reactions, B cell leukemia lymphoma (Bcl)-6 lymphocyte inducer maturation program (Blimp)-1, transcriptional factors immunoglobulin (Ig) production; concentrations Igs, their correlation, in patients without endometriosis.The analyzed fluid 98 patients, 46 endometriosis, 52 benign tumors.IL-1 TNF-α mRNAs IgG IgA were higher endometriosis...
The aim of the study was to evaluate anticancer effects baicalein in FRO anaplastic thyroid cancer (ATC) cells.FRO cells were treated with and viability measured by MTT assay. Cell apoptosis observed staining Hoechst dye. expression apoptotic proteins (Bax, Bcl-2, PARP, cytochrome c, caspase-3) inflammatory protein Cox-2 phosphorylation MAPKs Akt determined western blot.Treatment inhibited cell proliferation a time-dependent manner increased DNA fragmentation cells. Baicalein at 50 100 μM...
Abstract Background Transforming growth factor‐β (TGF‐β) is a major regulator of extracellular matrix (ECM) events, particularly collagen production. Aim We explored whether the expression metalloproteinases (MMPs) and are transcriptionally regulated by TGF‐β Smad signaling pathways, roles played NF‐κB mitogen‐activated protein kinase (MAPK) in normal, aged, human dermal fibroblasts. Methods quantified mRNA using real‐time PCR immunoblotting proteins from cells passage 5‐15. Results The...
Objectives Toll-like receptors (TLRs) detect microbial infections and they can directly induce innate host defense responses. TLR 2 has been shown to be primarily involved in the recognition of peptidoglycans lipoteichoic acid gram positive bacteria. 4 recognizes lipopolysaccharides acids from both gram-negative gram-positive Both mutations lead a reduced capacity elicit inflammation increase risk for negative infections. This study was performed investigate expressions their patients...
In the present study, we aimed to investigate molecular mechanisms and prophylactic effects of grape seed proanthocyanidin (GSP) on lipopolysaccharide (LPS)-stimulated human hepatic stellate cells (HSCs). Cell counting MTT assays were used assess cell viability in absence or presence GSP. Reverse transcription-quantitative PCR (RT-qPCR) was performed for several inflammation-related genes (NOD1, NOD2, TLR2, TLR4, IL-1 β, IL-6, IL-8, iNOS COX-2). The expression anti-inflammatory signaling...
We compared the efficacies of vildagliptin (50 mg twice daily) relative to pioglitazone (15 once as an add-on treatment metformin for reducing glycosylated hemoglobin (HbA1c) levels in Korean patients with type 2 diabetes. The present study was a multicenter, randomized, active-controlled investigation comparing effects and receiving stable dose but exhibiting inadequate glycemic control. Each patient underwent 16-week period either or metformin. mean changes HbA1c from baseline were -0.94%...
In diabetic retinopathy (DR), neutrophil extracellular traps (NET) and kallikrein-kinin system are considered as contributing factors. However, the detail activation mechanisms has not been fully understood. Since NET could provide negative-charged surface for factor XII activated (XIIa) can initiate system, this study investigated whether patients with DR show of NET, system.The markers related to (DNA-histone complex) (high-molecular-weight kininogen, prekallikrein, bradykinin) XIIa were...
Orostachys japonicus has been used in traditional medicine as an anticancer agent. The present study aimed to investigate the mechanism by which O. extract affects expression of matrix metalloproteinase (MMP)-2 and MMP-9, its association with inducible nitric oxide synthase (iNOS) cyclooxygenase-2 (COX-2) genes phorbol myristate acetate-differentiated THP-1 human monocytic leukemia cells how it mediates nuclear factor (NF)-κB mitogen-activated protein kinase (MAPK) pathways. Cell...
α-Melanocyte-stimulating hormone (α-MSH) and agouti-related peptide (AgRP) control energy homeostasis by their opposing actions on melanocortin receptors (MC3/4R) in the hypothalamus. We previously reported that thyroid transcription factor-1 (TTF-1) controls feeding behavior This study aims to identify function of TTF-1 transcriptional regulation AgRP α-MSH synthesis for behavior.TTF-1 activity pro-opiomelanocortin (POMC) was examined using gel-shift promoter assays an vivo model inhibition...
Abstract Background Early initiation of combination therapy using antihyperglycemic agents is recommended for treating type 2 diabetes (T2D). The present multicenter double‐blind randomized parallel‐group study examined the efficacy and safety a sitagliptin metformin fixed‐dose (Sita/Met) compared with glimepiride in T2D patients as initial treatment. Methods Type (aged ≥18 years) were to Sita/Met or 30 weeks after wash‐off run‐in period. primary endpoint was change from baseline (CFB)...
Orostachys japonicus (O. japonicus), used to treat diseases such as various cancers, gastric ulcers, fever, hepatitis, arthritis, eczema, for hemostasis, and intoxication in folk medicine, has been an important constituent many herbal formulae. We demonstrated that the water extract of O. led growth inhibition LX2 cells by inducing apoptosis through caspase activation, related MAPK pathway. inhibited proliferation a dose- time-dependent manner, increased fraction at cell cycle progression...
Abstract Aims/Introduction Recently, patient‐tailored statin therapy was proven effective for achieving target low‐density lipoprotein ( LDL ) cholesterol levels. It is unclear, however, whether this therapeutic modality would be atherogenic lipid profiles and inflammation in patients with type 2 diabetes. Materials Methods The present study an 8‐week, multicenter, single‐step titration trial of atorvastatin (10, 20 40 mg) according to baseline levels 440 We measured the particle size by...
We have recently found that thyroid transcription factor-1 (TTF-1), a homeodomain-containing factor, is postnatally expressed in discrete areas of the hypothalamus and closely involved neuroendocrine functions. now report cyclooxygenase-2 (COX-2), rate limiting enzyme prostaglandin biosynthesis, was inhibited by TTF-1. Double immunohistochemistry demonstrated TTF-1 astrocytes endothelial cells blood vessel hypothalamus. Promoter assays electrophoretic mobility shift showed COX-2 binding to...