A5100446909- Protein Structure and Dynamics
- Advanced Sensor and Energy Harvesting Materials
- Nanoparticle-Based Drug Delivery
- Micro and Nano Robotics
- Nanoplatforms for cancer theranostics
- Liver Disease Diagnosis and Treatment
- RNA Research and Splicing
- Photoacoustic and Ultrasonic Imaging
- Receptor Mechanisms and Signaling
- Advanced biosensing and bioanalysis techniques
- Medical Research and Treatments
- MRI in cancer diagnosis
- Hydrogels: synthesis, properties, applications
- Photodynamic Therapy Research Studies
- Advanced Materials and Mechanics
- Conducting polymers and applications
- Ion channel regulation and function
- Cardiac electrophysiology and arrhythmias
- Prion Diseases and Protein Misfolding
- Hepatocellular Carcinoma Treatment and Prognosis
- Diverse Industrial Engineering Technologies
- Extracellular vesicles in disease
- Nanocluster Synthesis and Applications
- Advanced Clustering Algorithms Research
- Cardiovascular Disease and Adiposity
The Synergetic Innovation Center for Advanced Materials
2021-2025
Nanjing University of Posts and Telecommunications
2021-2025
Qingdao University
2025
Zhongnan Hospital of Wuhan University
2025
Wuhan Prevention and Treatment Center for Occupational Diseases
2025
Texas A&M University
2023-2024
Huazhong University of Science and Technology
2024
Tongji Hospital
2024
Shenyang Pharmaceutical University
2022-2024
Yan'an University
2024
Polymer models serve as useful tools for studying the formation and physical properties of biomolecular condensates. In recent years, interface dividing dense dilute phases condensates has been discovered to be closely related their functionality, but conformational preferences constituent proteins remain unclear. To elucidate this, we perform molecular simulations a droplet formed by phase separation homopolymers surrogate model prion-like low-complexity domains. By systematically analyzing...
Intravitreal injections of antivascular endothelial growth factor (VEGF) agents are the primary method for treating retinal vein occlusion (RVO). However, complex structure eye anatomy presents ocular barriers that impede drug delivery. Additionally, these drugs only manage complications associated with RVO and fail to address underlying cause vessel occlusions. Here, we describe a utilizes functionalized magnetically driven nanorobots overcome treat RVO. These developed using hybrid...
Colloidal crystals with iridescent structural coloration have appealing applications in the fields of sensors, displays, anti-counterfeiting, etc. A serious issue accompanying facile chemical self-assembly approach to colloidal is formation uncontrolled and irregular cracks. In contrast previous efforts avoid cracking, unfavorable random micro-cracks were utilized here as unclonable codes for tamper-proof anti-counterfeiting. The special optical characteristics crystal patterns assembled...
Intrinsically disordered proteins (IDPs) can form biomolecular condensates through phase separation. It is recognized that the conformation of IDPs in dense and dilute phases, as well at the...
Stimuli-responsive hydrogels that undergo programmable shape deformation are of great importance for a wide variety applications spanning from soft robotics and biomedical devices to tissue engineering drug delivery. To guide morphing, anisotropic elements need be encoded into the during fabrication, which extremely difficult alter afterward. This study reports simple reliable mechanochemical regulation strategy postengineer by encoding structures high stiffness locally prestretched tough...
This paper explores the unique power and status of women during Tang Dynasty, a period in Chinese history characterized by political, social, economic, cultural transformation. held position, enjoying level influence distinct from other eras. By examining aspects, this reveals significant contributions to life Dynasty. Through analyzing historical records, imperial edicts, relics, we discover that had more opportunities politics, such as Empress Wu Zetian ascending throne, social life, like...
Microneedles as a typical device for transdermal drug delivery provide an alternative route administration with minimal digestion by organs and better patient compliance. However, diffusion of passively released molecules within the skin tissue mainly depends on interstitial fluid, which may be affected different physiological conditions individuals. Herein, we propose nanobubble-modified microneedle patch ultrasound-assisted delivery, provides additional driving force penetration molecules....
Material properties of phase-separated biomolecular assemblies, enriched with disordered proteins, dictate their ability to participate in many cellular functions. Despite the significant effort dedicated understanding how sequence protein drives its phase separation form condensates, little is known about determinants condensate material properties. Here, we computationally decipher these relationships for charged proteins using model sequences comprised glutamic acid and lysine residues as...
Biointerfacing nanomaterials with cell membranes has been successful in the functionalization of nanoparticles or nanovesicles, but microbubble remains challenging due to unique conformation lipid monolayer structure at gas-liquid interface that provides insufficient surfactant activity. Here, we describe a strategy rationally regulate activity platelet membrane vesicles by adjusting ratio proteins lipids through fusion synthetic phospholipids (i.e., liposomes). A "platesome" optimized...
Mode choice is important in shipping commodities efficiently. This paper develops a binary logit model and regression to study the cereal grains movement by truck rail United States using publically available Freight Analysis Framework (FAF2.2) database U.S. highway networks TransCAD, geographic information system with strong transportation modeling capabilities. The both use same set of generic variables, including mode split probability, commodity weight, value, network travel time, fuel...
Applications in the harsh environment require hydrogels with ultra-stiffness, toughness, and stretchability. However, it remains a challenge to increase elastic modulus without sacrificing maximum elongation of hydrogels, because trade-off between stiffness extensibility. Inspired by crosslinking hierarchy mussel byssus cuticle, here, we report strategy fabricate an ultra-stiff, tough stretchable triple-crosslinked (TC) hydrogel. The polymer is crosslinked chemical crosslinker at first,...
Rationale: Acute respiratory distress syndrome (ARDS) is a life-threatening condition characterized by excessive immune response usually due to lung inflammation. Local immunosuppression crucial for effective ARDS treatment. However, current methods are limited in their ability target the lungs specifically. Methods: This study utilized lung-targeted lipid nanoparticles (LNPs) with 1,2-dioleoyl-3-trimethylammonium-propane (termed DOTAP-LNPs) encapsulate chemically modified soluble programmed...
The use of anticoagulants has become more frequent due to the progressive aging population and increased thromboembolic events. Consequently, proportion anticoagulant-associated intracerebral hemorrhage (AAICH) in stroke patients is gradually increasing. Compared with (ICH) without coagulopathy, AAICH may have larger hematomas, worse prognoses, higher mortality. Given need for anticoagulant reversal resumption, management differs from that conventional medical or surgical treatments ICH, it...