A5015414972- 3D Printing in Biomedical Research
- Innovative Microfluidic and Catalytic Techniques Innovation
- Additive Manufacturing and 3D Printing Technologies
- Tissue Engineering and Regenerative Medicine
- Cancer Cells and Metastasis
- Neuroscience and Neural Engineering
- Cell Image Analysis Techniques
- Electrospun Nanofibers in Biomedical Applications
- Pluripotent Stem Cells Research
- Bone Tissue Engineering Materials
- Advanced Control Systems Optimization
- Angiogenesis and VEGF in Cancer
- Microfluidic and Capillary Electrophoresis Applications
- Rare-earth and actinide compounds
- Microfluidic and Bio-sensing Technologies
- Process Optimization and Integration
- Anatomy and Medical Technology
- Cancer Research and Treatments
- Nerve injury and regeneration
- Barrier Structure and Function Studies
- Biosensors and Analytical Detection
- Theoretical and Computational Physics
- Atherosclerosis and Cardiovascular Diseases
- Muscle Physiology and Disorders
- Silk-based biomaterials and applications
Chonnam National University
2020-2025
Guangdong Pharmaceutical University
2025
Government of the Republic of Korea
2023
Pohang University of Science and Technology
1999-2021
Korea Polytechnic University
2013
Korea Research Institute of Standards and Science
2000
Engineered skeletal muscle tissues that mimic the structure and function of native have been considered as an alternative strategy for treatment various muscular diseases injuries. Here, it is demonstrated 3D cell-printing decellularized extracellular matrix (mdECM)-based bioink facilitates fabrication functional constructs. The cellular alignment shape tissue constructs are controlled by technology. mdECM provides cell-printed with a myogenic environment supports high viability...
Three-dimensional (3D) tissue modeling is an emerging field of investigation for disease mechanisms, drug testing, and therapeutic effects human survival. Various methods have been developed to recapitulate mimetic microenvironments; however, they could mimic only the fragmentary phase disease. Cells should be tested under two-dimensional (2D) substrate or encapsulated into hydrogels, thus, cannot natural behaviors arrangements in body. 3D printing technology allows us create precisely...
Autologous cartilages or synthetic nasal implants have been utilized in augmentative rhinoplasty to reconstruct the shape for therapeutic and cosmetic purposes. cartilage is considered be an ideal graft, but has drawbacks, such as limited source, requirements of additional surgery obtaining autologous cartilage, donor site morbidity. In contrast, are abundantly available low biocompatibility than cartilages. Moreover, currently used grafts involve reshaping processes, by meticulous manual...
Abstract The vascular system, essential for human physiology, is vital transporting nutrients, oxygen, and waste. Since structures are involved in various disease pathogeneses exhibit different morphologies depending on the organ, researchers have endeavored to develop organ-specific models. While animal models possess sophisticated morphologies, they significant discrepancies from tissues due species differences, which limits their applicability. To overcome limitations arising these...
Traumatic brain injury is one of the leading causes accidental death and disability. The loss parts in a severely injured induces edema, neuronal apoptosis, neuroinflammation. Recently, stem cell transplantation demonstrated regenerative efficacy an brain. However, current therapy needs improvement to resolve issues such as low survival implanted cells differentiation into respective cells. We developed brain-derived decellularized extracellular matrix (BdECM) bioink that printable has...
Ultrasonic surface acoustic wave (SAW)-induced streaming flow (ASF) has been utilized for microfluidic control, patterning, and mixing. Most previous research employed cross-type SAW acousto-microfluidic mixers, in which the SAWs propagated perpendicular to direction. In this configuration, mixing was induced predominantly by horizontal component of force, usually much smaller than vertical component, leading energy inefficiency limited controllability. Here, we propose a vertical-type...
Abstract Despite significant research progress, tumor heterogeneity remains elusive, and its complexity poses a barrier to anticancer drug discovery cancer treatment. Response the same varies across patients, timing of treatment is an important factor in determining prognosis. Therefore, development patient‐specific preclinical models that can predict patient's response within short period imperative. In this study, printed gastric (pGC) model developed for chemotherapy using extrusion‐based...
Background: Powder-based 3D printing, an advanced additive manufacturing technique, can produce oral disintegrating tablets (ODTs) without disintegrants, creating larger-pored via layer-by-layer powder stacking for better water absorption than traditional tablets. Methods: This study focused on using powder-based printing to fabricate clozapine-based ODTs. Through central composite design (CCD), the formulation of ODTs was optimized rapid disintegration. Analytical techniques such as X-ray...
The consideration of both topographical and biochemical environmental cues is critical in the fabrication functional engineered skeletal muscle.
The development of curative therapy for bladder dysfunction is usually hampered owing to the lack reliable ex vivo human models that can mimic complexity bladder. To overcome this issue, 3D in vitro model systems offering unique opportunities engineer realistic tissues/organs have been developed. However, existing still cannot entirely reflect key structural and physiological characteristics native In study, we propose an urinary create biomimetic tissue structures dynamic microenvironments...
In scaffold-based tissue engineering, sufficient oxygen and nutrient supply into cells within a scaffold is essential to increase cell viability the proliferation rate. Generally, nutrients reach through media by diffusion in vitro or vivo, assuming there no convection flow with small-sized pores. The rate depends mainly on pore architecture. Thus, understanding effect of architecture mechanism necessary design an efficient model. This study proposes computational method estimate diffusivity...
Abstract Background Islet encapsulation techniques have shown limited success in maintaining islet survival and function because decreases oxygen supply. In this study, an oxygen‐generating scaffold was fabricated to prevent hypoxic cell damage improve the viability insulin secretion of islets. Methods We by mixing calcium peroxide (CaO 2 ) with polydimethylsiloxane ( PDMS ). evaluated effects + CaO on viability, caspase‐3 caspase‐7 activity, consumption rate OCR ), glucose‐stimulated GSIS...
Abstract 3D cell printing technology is in the spotlight for producing tissue or organ constructs useful various medical applications. In of neuromuscular tissue, a bioink satisfying all requirements challenging issue. Gel integrity and motor neuron activity are two major characters because harmonious combination extracellular materials essential to consists disadvantages mechanical properties. Here, method fabrication presented using porcine central nervous system decellularized matrix...