A5061974112- Liver Disease Diagnosis and Treatment
- Cervical Cancer and HPV Research
- Global Cancer Incidence and Screening
- Diet, Metabolism, and Disease
- Endometrial and Cervical Cancer Treatments
- Diet and metabolism studies
- Diabetes Treatment and Management
- Bladder and Urothelial Cancer Treatments
- Liver Diseases and Immunity
- Pancreatic function and diabetes
- Lung Cancer Treatments and Mutations
- Pregnancy and Medication Impact
- Reproductive tract infections research
- Cardiovascular Disease and Adiposity
- Receptor Mechanisms and Signaling
- Genetic factors in colorectal cancer
- Epigenetics and DNA Methylation
- Fibroblast Growth Factor Research
- Metabolism, Diabetes, and Cancer
- GDF15 and Related Biomarkers
- Genital Health and Disease
- Adipose Tissue and Metabolism
- Cancer Genomics and Diagnostics
- Extracellular vesicles in disease
- Vascular Malformations and Hemangiomas
Hvidovre Hospital
2017-2024
Copenhagen University Hospital
2010-2024
University of Copenhagen
2008-2023
Frederiksberg Hospital
2023
Danish Breast Cancer Cooperative Group
2012
Herlev Hospital
2008-2011
Bispebjerg Hospital
2011
Danish Cancer Society
2010
The bladder cancer genome harbors numerous oncogenic mutations and aberrantly methylated gene promoters. aim of our study was to generate a profile these alterations investigate their use as biomarkers in urine sediments for noninvasive detection cancer. We systematically screened FGFR3, PIK3CA, TP53, HRAS, NRAS KRAS quantitatively assessed the methylation status APC, ARF, DBC1, INK4A, RARB, RASSF1A, SFRP1, SFRP2, SFRP4, SFRP5 WIF1 prospective series tumor biopsies (N = 105) samples 113)...
Roux-en-Y gastric bypass (RYGB) improves, and can sometimes resolve, non-alcoholic fatty liver disease (NAFLD) steatohepatitis (NASH) but data based on histological assessment for the efficacy of sleeve gastrectomy (SG) in resolving NAFLD are sparse. Consequently, we aimed to compare RYGB vs. SG 12 months after surgery. In a prospective cohort study, 40 patients with obesity underwent bariatric surgery (16 24 SG). During surgery, biopsy was taken repeated later. severity evaluated using...
Abstract Impaired mitochondrial oxidative phosphorylation (OXPHOS) in liver tissue has been hypothesised to contribute the development of nonalcoholic steatohepatitis patients with fatty disease (NAFLD). It is unknown whether OXPHOS capacities human visceral (VAT) and subcutaneous adipose (SAT) associate NAFLD severity how hepatic responds improvement NAFLD. In biopsies sampled from 62 obesity undergoing bariatric surgery nine control subjects without we demonstrate that reduced VAT SAT...
Abstract Introduction For women treated for cervical dysplasia at 60–64 years in Denmark, we reported the frequency of abnormalities before and after treatment cervix uteri (most frequently performed as large loop excision transformation zone, LLETZ) using population‐based real‐world data. Material Methods We conducted a retrospective cohort study based on national data from Danish Pathology Data Bank identified who underwent LLETZ 2010–2016 age 60–64. Women were managed according to...
Background/Objectives: Visceral adipose tissue (VAT) may play a direct role in the development of metabolic dysfunction-associated steatotic liver disease (MASLD) and its progression to steatohepatitis (MASH). In this study, we employed untargeted proteomics analyses on paired biopsies from VAT tissues patients with obesity, MASLD, MASH. Our objective was investigate tissue-specific protein expression patterns search potential proteomic signature associated MASH both tissue. Methods: were...
Breast cancer is a very heterogeneous disease, encompassing several intrinsic subtypes with various morphological and molecular features, natural history response to therapy. Currently, targeted therapies are available for estrogen receptor (ER)(-) human epidermal growth factor 2 (Her2)-positive breast tumors. However, significant proportion of primary cancers negative ER, progesterone (PgR), Her2, comprising the triple (TNBC) group. Women TNBC have poor prognosis because aggressive nature...
Despite an intensive screening activity, the incidence of cervical cancer in Denmark has remained stable for last 15 years, while regional differences have increased. To search explanations, we investigated possible weaknesses program.Data on screen-targeted women were retrieved from Statistics Denmark. Data activity annual reports 2009 to 2015 quality screening. Coverage was calculated as proportion with at least one cytology sample within recommended time intervals. Insufficient follow-up...
Nonalcoholic fatty liver disease (NAFLD) is associated with impaired hepatic actions of glucagon and insulin. Glucagon amino acids are linked in an endocrine feedback circuit, the liver-alpha cell axis, that may be disrupted by NAFLD. We investigated how NAFLD severity affects insulin resistance individuals obesity whether bariatric surgery improves these parameters. Plasma biopsies from 33 (collectively, OBE) were obtained before 12 months after (Roux-en-Y gastric bypass [RYGB] or sleeve...
The Danish cervical cancer screening program is a cost-free prevention for all resident women aged 23–64 years. coverage 73%, but attendance slowly declining. Notwithstanding, almost half of newly diagnosed cancers are found amongst non-attenders. To increase attendance, the Capital Region Denmark implemented HPV self-sampling as an alternative offer to not attending regular offer. This was opt-in 57,717 non-attending in 2017–2018. They received invitation letter and could by letter, phone,...
Abstract Glucagon is a major regulator of metabolism and drugs targeting the glucagon receptor (GCGR) are being developed. Insight into tissue cell-specific expression GCGR important to understand biology differentiate between direct indirect actions glucagon. However, it has been challenging localize in due low levels lack specific methods. Immunohistochemistry frequently used for localization, but antibodies G-protein-coupled-receptors may be inaccurate. We evaluated all currently...
Abstract Fatty liver disease has mainly been characterized under fasting conditions. However, as the is essential for postprandial homeostasis, identifying disturbances may be important. Here, we investigated changes in markers of metabolic dysfunction between healthy individuals, obese individuals with non‐alcoholic fatty (NAFLD) and patients cirrhosis. We included biopsy‐proven NAFLD ( n = 9, mean age 50 years, BMI 35 kg/m 2 , no/mild fibrosis), cirrhosis hepatic steatosis 10, 62 32 CHILD...
Patients with autoimmune liver disease but without overt diabetes display glucose disturbances early on in their course. We identified pathophysiological traits specific to these patients including altered incretin responses.
Denmark went through various COVID-19 pandemic restrictions including periodic lockdowns from March 2020 to January 2022. All cancer screening programs were kept operational, yet access clinicians for cervical was at times limited. We assessed the impact of on activity in Capital Region Denmark. Cervical defined as regular by invitation, opportunistic screening, and participation HPV self-sampling. Activity monitored during post-pandemic compared relatively a 3-year pre-pandemic reference....
Abstract Cervical cancer is a preventable disease. Nevertheless, stagnation has been seen in incidence rates also countries with well‐functioning healthcare. On this basis, we investigated associations between control interventions and changes cervical Denmark from 2009 to 2022. Data on human papillomavirus (HPV)‐vaccination were retrieved Staten's Serum Institute; screening recommendations Danish Health Authority, performance Quality Database for Screening; Nordcan Cancer Register. We...
Introduction Danish women exit cervical cancer screening at age 65 years, but 23% of cases occur beyond this age. In addition, due to gradual implementation screening, older are underscreened by today´s standards. A one-time with HPV test was therefore offered born before 1948. Methods Register based study reporting histology diagnoses and conizations in found positive the screening. Number proportion severe or non-severe results were calculated for screened HPV-positive group region...
Hemangioma of the prostate gland is extremely rare and only a few cases have been reported. There several hemangioma posterior urethra, urinary bladder periprostatic plexus in literature, all presenting with hematuria or hematospermia. Diagnosis prostatic difficult due to its rarity unspecific symptoms such as hematuria, hematospermia lower tract symptoms. It cannot be detected by conventional examinations cystoscopy standard rectal ultrasonography.We present case an 84-year old male...
To assess outcome of a one-time human papillomavirus (HPV)-screening in 2017 Danish women aged 70+.Women born 1947 or before were personally invited to have cell-sample collected by their general practitioner. Screening- and follow-up samples analyzed hospital laboratories the five regions registered centrally. Follow-up procedures varied slightly across regions. Cervical intraepithelial neoplasia 2 (CIN2) was recommended treatment threshold. Data retrieved from Quality Database for Cancer...
Coccidioidomycosis is a fungal infection that usually presents as primary lung infection. The fungus endemic to the Southwest United States of America, northern Mexico and parts Central South America rare outside these areas. However, some patients develop disseminated can lie dormant for several years present itself in travelers. We report first case extra pulmonary non-immunocompromised individual Denmark. A 32 year old Danish woman presented at Emergency department with abdominal pain....
Increased plasma concentrations of glucagon (hyperglucagonemia) are reported in patients with type 2 diabetes (T2D) and considered a diabetogenic risk factor. Emerging evidence suggests that hepatic steatosis obesity is causing condition resistance toward glucagon's effects on amino acid metabolism, resulting an acid-induced hyperglucagonemia. We investigated the presence hyperglucagonemia individuals biopsy-verified metabolic dysfunction-associated steatotic liver disease (MASLD), whether...
Abstract Broad accessibility to cervical cancer screening and high participation rate is essential reduce incidence. HPV self‐sampling an alternative clinician collected samples increase coverage. To inform on deployment strategies of self‐sampling, this large‐scale, randomized, pragmatic study compared two invitation modalities; direct‐mail opt‐in. The included non‐attenders from the Capital Region Denmark randomly allocated (1:4) a or opt‐in for by self‐sampling. Primary endpoint was...
Abstract Aim Increased growth differentiation factor 15 (GDF15) may reflect impaired metabolic health and an inflammatory state in dysfunction‐associated steatotic liver disease (MASLD). We investigated the role of GDF15 histologically verified MASLD a meal test (discovery) cohort ( n = 20) prospective (validation) with 2 years follow‐up 276). Methods Participants were evaluated clinically both cohorts. Fibrosis severity was classified as no/mild (F0/F1) or significant (F2–4). Plasma...