A5026857344- SARS-CoV-2 and COVID-19 Research
- Influenza Virus Research Studies
- Respiratory viral infections research
- COVID-19 Clinical Research Studies
- Animal Disease Management and Epidemiology
- Immunotherapy and Immune Responses
- interferon and immune responses
- Animal Virus Infections Studies
- Plant Gene Expression Analysis
- Monoclonal and Polyclonal Antibodies Research
- vaccines and immunoinformatics approaches
- SARS-CoV-2 detection and testing
- Plant biochemistry and biosynthesis
- COVID-19 epidemiological studies
- Viral gastroenteritis research and epidemiology
- T-cell and B-cell Immunology
- Machine Learning in Bioinformatics
- Phytochemicals and Antioxidant Activities
- Inflammasome and immune disorders
- Protein Structure and Dynamics
- Genomics and Phylogenetic Studies
- Multimodal Machine Learning Applications
- Human Motion and Animation
- Immune cells in cancer
- Multi-Agent Systems and Negotiation
Fujian Academy of Agricultural Sciences
2024
Institute of Food Science and Technology
2024
Fujian Agriculture and Forestry University
2024
St. Jude Children's Research Hospital
2020-2024
Shandong First Medical University
2024
Ministry of Agriculture and Rural Affairs
2024
Shandong Provincial Hospital
2024
University of Tennessee Health Science Center
2021-2023
Children's Research Hospital
2020-2023
National Health Research Institutes
2015-2022
SARS-CoV-2 infection causes diverse outcomes ranging from asymptomatic to respiratory distress and death. A major unresolved question is whether prior immunity endemic, human common cold coronaviruses (hCCCoVs) impacts susceptibility or following vaccination. Therefore, we analyzed samples the same individuals before after We found hCCCoV antibody levels increase exposure, demonstrating cross-reactivity. However, a case-control study indicates that baseline are not associated with protection...
Generating visual text in natural scene images is a challenging task with many unsolved problems. Different from generating on artificially designed (such as posters, covers, cartoons, etc.), the needs to meet following four key criteria: (1) Fidelity: generated should appear realistic photograph and be completely accurate, no errors any of strokes. (2) Reasonability: reasonable carrier areas boards, signs, walls, content also relevant scene. (3) Utility: can facilitate training OCR (Optical...
Recent advancements in large language models (LLMs) have broadened their application scope but revealed challenges balancing capabilities across general knowledge, coding, and mathematics. To address this, we introduce a Collaborative Semantic Experts (CoE) approach for supervised fine-tuning (SFT), which employs two-phase training strategy. Initially, expert fine-tunes the feed-forward network on specialized datasets, developing distinct experts targeted domains. Subsequently, leveraging...
Background After anterior cruciate ligament (ACL) reconstruction, some patients suffered from sensory disturbance around the surgical incision of leg. This research was aimed to investigate relationship between different skin incisions and injury infrapatellar branch saphenous nerve (IPBSN) post ACL reconstruction. Methods reconstructions were performed with quadruple hamstring tendon for 60 patients. Sensory followed up at an average 14.5±4.7 months operation. Among patients, vertical 35...
Abstract SARS-CoV-2 has caused millions of infections worldwide since its emergence in 2019. Understanding how infection and vaccination induce mucosal immune responses they fluctuate over time is important, especially are key preventing reducing disease severity. We established a novel methodology for assessing cytokine antibody at the nasal epithelium by using nasopharyngeal swabs collected longitudinally before after either or vaccination. then compared between systemic compartments....
Abstract Background Influenza A virus (IAV) evolves strategies to counteract the host antiviral defense for establishing infection. The influenza non-structural protein 1 (NS1) is a key viral factor shown type I IFN response mainly through targeting RIG-I signaling. Growing evidence suggests that RNA sensors RIG-I, TLR3, and TLR7 function detect IAV in different cell types induce Yet, it remains unclear if NS1 can exploit common mechanism these sensing pathways production at once, then...
Although mRNA vaccine efficacy against severe COVID-19 remains high, variant emergence and breakthrough infections have changed policy to include booster immunizations. However, the effect of diverse repeated antigen exposures on SARS-CoV-2 memory T cells is poorly understood. Here, we utilize DNA-barcoded MHC-multimers combined with scRNAseq scTCRseq capture ex vivo profile SARS-CoV-2-responsive within a cohort individuals one, two, or three exposures, including vaccination, primary...
Avian-origin influenza A (H7N9) viruses emerged as human pathogens in China early 2013 and have killed >100 persons. Influenza vaccines are mainly manufactured using egg-based technology which could not meet the surging demand during pandemics. In this study, we evaluated cell-based H7N9 ferrets. An egg-derived reassortant vaccine virus was adapted MDCK cells. whole antigen a microcarrier-based culture system. Immunogenicity protection of candidates with three different formulations (300μg...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in late 2019 and has since caused a global pandemic resulting millions of cases deaths. Diagnostic tools serological assays are critical for controlling the outbreak, especially designed to quantitate neutralizing antibody levels, considered best correlate protection. As vaccines become increasingly available, it is important identify reliable methods measuring responses that with authentic virus neutralization but can be...
Abstract Purpose Intraductal carcinoma of the prostate (IDC-P) is a histological subtype that differs from conventional acinar adenocarcinoma in terms its origin, appearance, and pathological features. For IDC-P, there currently no recognized best course action, prognosis unclear. The goal this study to analyze independent prognostic factors IDC-P patients develop validate nomogram predict overall survival (OS) cancer-specific (CSS). Methods Clinical data for were collected Surveillance,...
Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are key RNA viral sensors for triggering antiviral immunity. The underlying mechanisms RLRs to trigger immunity have yet be explored. Here we report the identification of TAPE (TBK1-associated protein in endolysosomes) as a novel regulator RLR pathways. functionally and physically interacts with RIG-I, MDA5, IPS-1 activate IFN-β promoter. knockdown impairs activation induced by but not IPS-1. TAPE-deficient cells defective cytokine...
The efficacy of coronavirus disease 2019 (COVID-19) vaccines administered after COVID-19-specific monoclonal antibody is unknown, and "antibody interference" might hinder immune responses leading to vaccine failure. In an institutional review board-approved prospective study, we found that individual who received mRNA COVID-19 vaccination <40 days therapy for symptomatic had similar postvaccine SARS-CoV-2 receptor binding domain (RBD) 4 important variants (B.1, B.1.1.7, B.1.351, P.1) as...
Infection and vaccination repeatedly expose individuals to antigens that are conserved between influenza virus subtypes. Nevertheless, antibodies recognizing variable epitopes greatly outnumber reactive against epitopes. Elucidating factors contributing the paucity of broadly remains a major obstacle for developing universal vaccine. Here, we report inducing increases autoreactive in humans mice exacerbates disease four distinct models autoimmune disease. Importantly, transferring augments...
Proanthocyanidins (PAs) are a class of polyphenolic compounds recognized for their potent antioxidant, anti-cancer, anti-inflammatory, and cardioprotective properties. However, the production PAs from natural sources is often limited by high costs, resource wastage, environmental damage. In this study, we investigated overexpression
Following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection or vaccination there is significant variability between individuals in protective antibody levels against SARS-CoV-2, and within different virus variants. However, host demographic clinical characteristics that predict cross-reactive are not well-described. These data could inform clinicians, researchers, policymakers on the populations most likely to require vaccine booster shots.In an institutional review...
Human infections with avian-origin H7N9 influenza A viruses were first reported in China, and an approximately 38% human mortality rate was described across six waves from February 2013 to September 2018. Vaccination is one of the most cost-effective ways reduce morbidity during epidemics pandemics. Egg-based platforms for production vaccines are labor-intensive unable meet surging demand Therefore, cell culture-based technology becoming alternative strategy producing vaccines. The current...
Novel low-pathogenic avian influenza (LPAI) H5N2 viruses hit poultry farms in Taiwan 2003, and evolved into highly pathogenic (HPAI) 2010. These are reassortant containing HA NA genes from American-lineage six internal local H6N1 viruses. According to a serological survey, the can cause asymptomatic infections workers. Therefore, development of vaccines is desirable for pandemic preparation. In this study, we employed reverse genetics generate vaccine virus having A/Chicken/CY/A2628/2012...
Outbreaks of infection by novel avian influenza virus strains in humans cause public health issues worldwide, and the development vaccines against such is most effective method for prevention these outbreaks. All types must be tested potency before use; thus, quantitative assays are needed vaccines. The single radial immunodiffusion (SRID) assay considered gold standard quantification antigens, SRID reference reagents essential determination vaccine potency. However, it remains debatable...
Herpes zoster (HZ) is caused by the reactivation of latent varicella-zoster virus (VZV) from sensory ganglia due to aging or immunosuppression. Glycoprotein E (gE) a widely used vaccine antigen for specific humoral and cellular immune responses. Immediate early protein 63 (IE63) expressed during latency, suggesting that it potential against HZ reactivation. In this study, DNA vaccines encoding gE, IE63, IE63-2A-gE (where 2A self-cleaving sequence), IE63-linker-gE were developed investigated...
Abstract Large language models are renowned for their efficacy in capturing intricate patterns, including co-evolutionary relationships, and underlying protein languages. However, current methodologies often fall short illustrating the emergence of genomic insertions, duplications, insertion/deletions (indels), which account approximately 14% human pathogenic mutations. Given that structure dictates function, mutated proteins with similar structures more likely to persist throughout...
<title>Abstract</title> Large language models are renowned for their efficacy in capturing intricate patterns, including co-evolutionary relationships, and underlying protein languages. However, current methodologies often fall short illustrating the emergence of genomic insertions, duplications, insertion/deletions (indels), which account approximately 14% human pathogenic mutations. Given that structure dictates function, mutated proteins with similar structures more likely to persist...