A5059579060- Renal and related cancers
- Epigenetics and DNA Methylation
- Genetic and Kidney Cyst Diseases
- Paleontology and Stratigraphy of Fossils
- RNA Research and Splicing
- Calcium Carbonate Crystallization and Inhibition
- Pharmacological Effects of Medicinal Plants
- Physiological and biochemical adaptations
- Zebrafish Biomedical Research Applications
- Developmental Biology and Gene Regulation
- Pelvic floor disorders treatments
- Reproductive Biology and Fertility
- Enzyme Structure and Function
- Genomics and Chromatin Dynamics
- Erythrocyte Function and Pathophysiology
- Fish Ecology and Management Studies
- Connexins and lens biology
- Prostate Cancer Diagnosis and Treatment
- Reproductive System and Pregnancy
- Caveolin-1 and cellular processes
- Retinal Development and Disorders
- Pickering emulsions and particle stabilization
- Crystallization and Solubility Studies
- Barrier Structure and Function Studies
- Urinary Bladder and Prostate Research
Hebrew University of Jerusalem
2021-2025
Weizmann Institute of Science
2022-2024
Drexel University
2017
Lankenau Institute for Medical Research
2017
Highlights•The Balbiani forms in oogenesis by developmental molecular condensation of Buc•Bb evolves from dynamic, liquid-like Buc granules to a solid, stable compartment•Multistep regulation microtubules controls condensation, ensuring polarity•Novel candidate regulators, partners, and targets are identifiedSummaryVertebrate oocyte polarity has been observed for two centuries is essential embryonic axis formation germline specification, yet its underlying mechanisms remain unknown. In...
A hallmark of meiosis is chromosomal pairing, which requires telomere tethering and rotation on the nuclear envelope through microtubules, driving chromosome homology searches. Telomere pulling toward centrosome forms "zygotene bouquet." Here, we identified cilium" in oocytes. This cilium provides a cable system for bouquet machinery extends throughout germline cyst. Using zebrafish mutants live manipulations, demonstrate that anchors to counterbalance pulling. The essential synaptonemal...
Organisms evolve mechanisms that regulate the properties of biogenic crystals to support a wide range functions, from vision and camouflage communication thermal regulation. Yet, mechanism underlying formation diverse intracellular remains enigmatic. Here we unravel biochemical control over crystal morphogenesis in zebrafish iridophores. We show chemical composition determines their shape, particularly through ratio between nucleobases guanine hypoxanthine. reveal these variations are...
Many animals exhibit remarkable colors that are produced by the constructive interference of light reflected from arrays intracellular guanine crystals. These can fine-tune their crystal-based structural to communicate with each other, regulate body temperature, and create camouflage. While it is known these changes in color caused angle crystal relative incident light, cellular machinery drives change not understood. Here, using a combination 3D focused ion beam scanning electron microscopy...
Controlling the morphology of crystalline materials is challenging, as crystals have a strong tendency toward thermodynamically stable structures. Yet, organisms form with distinct morphologies, such plate-like guanine produced by many terrestrial and aquatic species for light manipulation. Regulation crystal morphogenesis was hypothesized to entail physical growth restriction surrounding membrane, combined fine-tuned interactions between organic molecules growing crystal. Using...
The oral epithelium represents a major interface between an organism and its external environment. Improving this barrier at the molecular level can provide added protection from microbial-based diseases. Barrier function of Gie-3B11-human-gingival-epithelial-cell-culture model is enhanced by micronutrients zinc, quercetin, retinoic acid, acetyl-11-keto-β-boswellic as observed concentration-dependent increase in transepithelial electrical resistance decrease 14C-d-mannitol permeability. With...
Human semen has the potential to modulate epithelial mucosal tissues it contacts, as seminal plasma (SP) is recognized contain both pro- and anti-barrier components, yet its effects on barrier function are largely unknown. We addressed role of human SP when exposed basal-lateral surface, a situation that would occur clinically with prior mechanical or disease-related injury cell layers in contact semen. The action claudins-2, -4, -5, -7 expression, well target epithelium whose basolateral...
Many animals exhibit remarkable colors produced by the constructive interference of light reflected from arrays intracellular guanine crystals. These systems are utilized for various purposes, including vision, camouflage, communication, and thermal regulation. Each crystal forms within a membrane-bound organelle called an iridosome, where precise control over formation occurs. While presence crystals in iridosomes is well-documented, mechanisms facilitating accumulation water-insoluble...
Abstract The Balbiani body (Bb) is a membraneless organelle that forms in oocytes from insects to humans. In most vertebrates the Bb contains essential RNA-protein (RNP) granules, establishes oocyte polarity, and required embryogenesis reproduction. mammals associated with primordial follicle formation. However, despite its discovery 1845, mechanisms of formation are still unknown any species. Here, we discovered zebrafish. We first provide three lines live-imaging, molecular, biochemical...
Abstract The hallmark of meiosis is chromosomal pairing and synapsis via synaptonemal complexes, but also depends on cytoplasmic counterparts that tether rotate telomeres the nuclear envelope. Telomeres slide perinuclear microtubules, shuffling chromosomes mechanically driving their homology searches. Pull towards centrosome drives formation “zygotene bouquet”. These telomere dynamics are essential for fertility, bouquet, discovered in 1900, universally conserved. Nevertheless, how bouquet...
Abstract Controlling the morphology of crystalline materials is challenging, as crystals have a strong tendency towards thermodynamically stable structures. Yet, organisms form with distinct morphologies, such plate-like guanine produced by many terrestrial and aquatic species for light manipulation. Regulation crystal morphogenesis was hypothesized to entail physical growth restriction surrounding membrane, combined fine-tuned interactions between organic molecules growing crystal. Using...