A5101499885- Sirtuins and Resveratrol in Medicine
- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Nerve injury and regeneration
- Biochemical effects in animals
- Bioactive natural compounds
- Biochemical and biochemical processes
- Olfactory and Sensory Function Studies
- Neuroendocrine regulation and behavior
- Photoreceptor and optogenetics research
- RNA regulation and disease
- Genomics, phytochemicals, and oxidative stress
- Cancer Treatment and Pharmacology
- Stress Responses and Cortisol
- PARP inhibition in cancer therapy
- Calcium signaling and nucleotide metabolism
Shandong University
2009-2021
Alzheimer's disease (AD) is characterized by the accumulation of β-amyloid peptide (Aβ) and loss neurons. Recently, a growing body evidences have indicated that as herbal compound naturally derived from grapes, resveratrol modulates pathophysiology AD, however, with largely unclear mechanism. Therefore, we aimed to investigate protection against neurotoxicity 25–35 (Aβ25–35) further explore its underlying mechanism in present study. PC12 cells were injuried Aβ25–35, at different...
Rotenone is a common pesticide and has been reported as one of the risk factors for Parkinson disease. can cause neuronal death or apoptosis through inducing oxidative injury inhibiting mitochondrial function. As natural polyphenolic compound, resveratrol possesses antioxidant capacity neuroprotective effect. However, mechanism underlying effect against rotenone-induced neurotoxicity remains elusive. Here, we treated PC12 cells with rotenone to induce neurotoxicity, neurotoxic were subjected...
Abstract Resveratrol (3,5,4'‐tihydroxy‐trans‐stilbene), a polyphenolic phytoalexin found in the skin and seeds of grapes, has been reported to possess wide range biological pharmacological activities including antioxidant, anti‐inflammatory, antimutagenic effects. The present study intended explore neuroprotective effects resveratrol against Aβ 25–35 ‐induced neurotoxicity cultured mouse cortical neurons possible mechanisms involved. For this purpose, were exposed 30 μM absence or presence...
Resveratrol, herbal nonflavonoid polyphenolic compound naturally derived from grapes, has long been acknowledged to possess extensive biological and pharmacological properties including antioxidant anti-inflammatory ones may exert a neuroprotective effect on neuronal damage in neurodegenerative diseases. However, the underlying molecular mechanisms remain undefined. In present study, we intended investigate effects of resveratrol against 6-OHDA-induced neurotoxicity PC12 cells further...
Resveratrol is originally extracted from huzhang, a Chinese herbal medicine. Recently, resveratrol has attracted great of attention due to its antioxidant and antiapoptotic properties. Although the neuroprotection on neural damages in various models been well characterized, little known about role methamphetamine (MA) induced neurotoxicity mesencephalic dopaminergic neurons. Dopaminergic neurons were isolated midbrain mouse embryos at embryonic day 15 cultured presence MA resveratrol. Cell...
Buyang Huanwu decoction (BYHWD), as a popular traditional Chinese medicine formula, was widely used for treating ischemic diseases. However, in the area of neurodegenerative diseases, researches focused on BYHWD are rare but promising, and molecular mechanisms underlying largely elusive. 6-Hydroxydopamine (6-OHDA), dopaminergic-specific neurotoxin, is extensively to establish neurotoxic model vivo vitro. In our present study, we prepared drug-containing serum (Buyang [BYHWS]) based...
Axonal degeneration is a common pathological change of neurogenical disease which often arises before the neuron death. But it had not found any effective method to protect axon from degeneration. In this study we intended confirm protective effect nicotinamide adenine dinucleotide (NAD), investigate optimal administration dosage and time NAD, identify relationship between silence signal regulating factor 1 (SIRT1) axonal An model was established using dorsal root ganglion (DRG) neurons...
The social deficit is a prevailing symptom in stress-induced depression. Although interaction behavior has been widely studied humans and rodents, it imprecise to record the between two free-moving mice via perusal. In present study, we applied an approach analyze using software named "MiceProfiler." C57BL/6J were stressed chronic restraint stress (CRS) housed three populations of different sizes as follows: single, cage, six cage. MiceProfiler was used video behavioral repertoire and,...
Nicotinamide adenine dinucleotide (NADH) has been reported to regulate synaptic plasticity recently, while its role in this process remains unclear. To explore the contribution and underlying mechanisms of NADH regulating plasticity, here, we examined NADH's effect on immediate-early response genes (IEGs) expressions, including C-Fos Arc primary cultured cortical neurons frontal cortex mouse brain. Our results showed that promoted IEGs expression levels are increased neurons, which is almost...